Iron affects the structure of cell membrane molecular models

Suwalsky, Mario; Martínez, Fernando Martínez; Cárdenas, Hernán; Grzyb, Joanna; Strzałka, Kazimierz

doi:10.1016/j.chemphyslip.2004.12.004

Cited by 22 publications

(12 citation statements)

References 31 publications

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“…Cholesterol is a determinant of membrane fluidity and plays a role in the function of membrane proteins. It is reasonable and consistent with published data to hypothesize that ferrous ion induced radical generation leads to membrane disturbances and in a compensatory response the cells may attempt to increase the cholesterol synthetic capacity [34][35][36]. In reports published so far the Fe(II)-dependent effects on cholesterol metabolism vary depending on the experimental system used.…”

Section: Discussionsupporting

confidence: 76%

Control of smooth muscle cell proliferation by ferrous iron

et al. 2006

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Section: Discussionsupporting

confidence: 76%

Control of smooth muscle cell proliferation by ferrous iron

et al. 2006

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“…2) and those demonstrated earlier [41], iron cations at a concentration of 10 −6 M, which is approximately comparable to the concentration of free iron dissolved in human serum [42], produced a little effect on the DMPC melting (Fig. 2c), while the quercetin-iron complex depressed both the pretransition and the main phase transition of the lipid (Fig.…”

Section: Resultssupporting

confidence: 63%

Integration of Quercetin-Iron Complexes into Phosphatidylcholine or Phosphatidylethanolamine Liposomes

Kim

Tarahovsky

Yagolnik

et al. 2015

Appl Biochem Biotechnol

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It is well known that flavonoids can chelate transition metals. Flavonoid-metal complexes exhibit a high antioxidative and therapeutic potential. However, the complexes are frequently hydrophobic ones and low soluble in water, which restricts their medical applications. Integration of these complexes into liposomes may increase their bioavailability and therapeutic effect. Here, we studied the interaction of quercetin-iron complexes with dimyristoylphosphatidylcholine (DMPC) or palmitoyl-oleoyl phosphatidylethanolamine (POPE) multilamellar liposomes. Differential scanning calorimetry (DSC) and freeze-fracture electron microscopy revealed that quercetin-iron complexes did not interact with liposomes. Quercetin however could penetrate lipid bilayers, when added to liposomes at a temperature above lipid melting. Iron cations added later penetrated into the lipid bilayers and produced complexes with quercetin in the liposomes. The quercetin-iron entry in POPE liposomes was improved when the suspension was heated above the temperature of the bilayer-hexagonal HII phase transition of the lipid. The approach proposed facilitates the integration of quercetin-iron complexes into liposomes and may promote their use in medicine.

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“…In addition, changes in the structure and function of phospolipid bilayers modulated by Fe 3+ can also influences the cell membrane permeability. 32 As expected, MAN-loaded erythrocytes start dissociating iron ions out from maghemite nanoparticles, due to both the low pH found CNS and the tissue metabolic activity. 33 Data from the literature demonstrated that iron distribution in nerve tissue is influenced by metabolic activity and ATP requirements, development stage, age, and region.…”

Section: Resultsmentioning

confidence: 85%

Successful Strategy for Targeting the Central Nervous System Using Magnetic Albumin Nanospheres

Silva¹,

Estevanato²,

Simioni³

et al. 2012

j biomed nanotechnol

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This study reports on the successful use of magnetic albumin nanosphere (MAN), consisting of maghemite nanoparticles hosted by albumin-based nanosphere, to target different sites within the central nervous system (CNS). Ultrastructural analysis by transmission electron microscopy (TEM) of the material collected from the mice was performed in the time window of 30 minutes up to 30 days after administration. Evidence found that the administered MAN was initially internalized and transported by erythrocytes across the blood-brain-barrier and transferred to glial cells and neuropils before internalization by neurons, mainly in the cerebellum. We hypothesize that the efficiency of MAN in crossing the BBB with no pathological alterations is due to the synergistic effect of its two main components, the iron-based nanosized particles and the hosting albumin-based nanospheres. We found that the MAN in targeting the CNS represents an important step towards the design of nanosized materials for clinical and diagnostic applications.

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Iron affects the structure of cell membrane molecular models

Cited by 22 publications

References 31 publications

Control of smooth muscle cell proliferation by ferrous iron

Control of smooth muscle cell proliferation by ferrous iron

Integration of Quercetin-Iron Complexes into Phosphatidylcholine or Phosphatidylethanolamine Liposomes

Successful Strategy for Targeting the Central Nervous System Using Magnetic Albumin Nanospheres

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