Iron and copper in male reproduction: a double-edged sword

Tvrdá, Eva; Peer, Rohan; Sikka, Suresh C.; Agarwal, Ashok

doi:10.1007/s10815-014-0344-7

Cited by 156 publications

(91 citation statements)

References 152 publications

(172 reference statements)

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“…Excess of this element may lead to defective spermatogenesis, reduced libido, and oxidative damage to the testicular tissue and spermatozoa, ultimately leading to fertility impairment [41]. Iron can affect male and female fertility by induction of reactive oxygen species (ROS) production.…”

Section: Discussionmentioning

confidence: 99%

Protective role of Limonium bonduelli extract against non-enzymatic peroxidation in brain and testes induced by iron in vitro.

Amrani

Boubekri

Benaissa

et al. 2017

ijpm

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A b s t r a c tInfertility and Neurodegerative diseases have been linked to oxidative stress arising from peroxidation of membrane biomolecules and high levels of iron have been reported to play an important role. The present study sought to determine the antioxidant act ability of brain and testes homogenates flowers)was prepared, and the ability of the in isolated rat brain and testes was determined using spectrophotometric method. The study revealed that the extract inhibited malondialdehyde (MDA) production in FeSO peroxidation in the b of the inhibition was 89.80% similar to vitamin C in the same concentration (100 µg/mL) in brain and 82.33% in testes (200 µg/mL). anti oxidative stress to its phytochemical content.

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Section: Discussionmentioning

confidence: 99%

Protective role of Limonium bonduelli extract against non-enzymatic peroxidation in brain and testes induced by iron in vitro.

Amrani

Boubekri

Benaissa

et al. 2017

ijpm

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“…Iron may be generally characterized by a so-called double-edged sword activity reflecting on its ability to either maintain cellular homeostasis as an essential micronutrient or to disturb this delicate balance as a catalyst responsible for reproductive dysfunction [1]. Disproportionate levels of iron have been shown to cause testicular atrophy, morphological changes in the testes, Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Iron (Fe) is an essential trace nutrient, playing crucial roles as a cofactor required for diverse bioactive molecules and pathways involved in health and disease [1]. Being one of the most abundant micronutrients in the organism, iron is involved in the synthesis of nucleic acids or proteins, electron transport and respiration, as well as cell proliferation and differentiation [2], all of which are closely related to spermatozoa production and metabolism [3].…”

Section: Introductionmentioning

confidence: 99%

Dose- and Time-Dependent In Vitro Effects of Divalent and Trivalent Iron on the Activity of Bovine Spermatozoa

Tvrdá

Lukáč

Lukáčová

et al. 2015

Biol Trace Elem Res

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This in vitro study was designed to assess the impact of divalent (Fe(2+)) or trivalent (Fe(3+)) iron on the activity and oxidative balance of bovine spermatozoa at specific time intervals (0, 2, 8, 16, and 24 h) during an in vitro culture. Forty-five semen samples were collected from adult breeding bulls and diluted in physiological saline solution supplemented with different concentrations (0, 1, 5, 10, 50, 100, 200, 500, 1000 μmol/L) of FeCl2 or FeCl3. Spermatozoa motion parameters were assessed using the SpermVision™ computer-aided sperm analysis (CASA) system. Cell viability was examined with the metabolic activity 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the nitroblue-tetrazolium (NBT) test was applied to quantify the intracellular superoxide formation. Both divalent and trivalent iron exhibited a dose- and time-dependent impact on the spermatozoa physiology and oxidative balance. Concentrations ≥50 μmol/L FeCl2 and ≥100 μmol/L FeCl3 led to a significant decrease of spermatozoa motility (P < 0.05) and mitochondrial activity (P < 0.001 with respect to 200-1000 μmol/L FeCl2/FeCl3; P < 0.01 in case of 100 μmol/L FeCl2/FeCl3), accompanied by a significant superoxide overproduction (P < 0.001 in terms of 200-1000 μmol/L FeCl2 and 500-1000 μmol/L FeCl3; P < 0.01 with respect to 100 μmol/L FeCl2 and 100-200 μmol/L FeCl3). On the other hand, concentrations below 10 μmol/L FeCl2 and 50 μmol/L FeCl3 proved to stimulate the spermatozoa activity, as shown by a significant preservation of the motility and viability characteristics (P < 0.001 in case of the motility parameters; P < 0.01 with respect to the spermatozoa viability), alongside a significant decline of the superoxide generation (P < 0.05). In a direct comparison, divalent iron has been shown to be more toxic than trivalent iron. Results from this in vitro study show that high concentrations of both forms of iron are toxic, while their low concentrations may have spermatozoa activity-promoting properties. In vitro concentrations of divalent or trivalent iron that could be regarded as critical are 50 μmol/L FeCl2 and 100 μmol/L FeCl3 when iron ceases to be an essential micronutrient in order to become a toxic risk factor.

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“…Physiological changes of the body iron during hematopoiesis -including absorption, utilization, and storage of iron -are closely related to copper [31]. Copper make inorganic iron into organic iron, (in other words, can transform ferric iron) to push iron from storage into the bone marrow, accelerating the synthesis of hemoglobin and porphyrin.…”

Section: Trace Element Coppermentioning

confidence: 99%