Iron and Oxidative Stress

Crichton, Robert R.

doi:10.1002/0470845791.ch10

Cited by 3 publications

(1 citation statement)

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“…In addition, iron may participate in the genesis of reactive oxygen species (ROS) through the Fenton and Haber–Weiss reactions (Wardman and Candeias, 1996). Production of ROS alters proteins, lipids, and DNA during oxidative stress favoring the development of cellular alterations that lead to the development of lesions in organs (Meneghini, 1997; Crichton, 2001b). …”

Section: Introductionmentioning

confidence: 99%

Iron, hepcidin, and the metal connection

et al. 2014

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Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases. However, from both experimental data and clinical findings, “iron-related proteins” appear to also be involved in the metabolism of other metals, especially divalent cations. Reports have demonstrated that some metals may affect, directly or indirectly, the expression of proteins involved in iron metabolism. Throughout their lives, individuals are exposed to various metals during personal and/or occupational activities. Therefore, better knowledge of the connections between iron and other metals could improve our understanding of iron-related diseases, especially the variability in phenotypic expression, as well as a variety of diseases in which iron metabolism is secondarily affected. Controlling the metabolism of other metals could represent a promising innovative therapeutic approach.

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Section: Introductionmentioning

confidence: 99%