Iron‐Based Nanozymes in Disease Diagnosis and Treatment

Abstract

Iron-based nanozymes are currently one of the few clinical inorganic nanoparticles for disease diagnosis and treatment. Overcoming the shortcomings of natural enzymes, such as easy inactivation and low yield, combined with their special nanometer properties and magnetic functions, iron-based nanozymes have broad prospects in biomedicine. This minireview summarizes their preparation, biological activity, catalytic mechanism, and applications in diagnosis and treatment of diseases. Finally, challenges to their future development and the trends of iron-based nanozymes are discussed. The purpose of this minireview is to better understand and reasonably speculate on the rational design of iron-based nanozymes as an increasingly important new paradigm for diagnostics.

A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer's disease

“…It is generally believed that iron-based NPs can react with H 2 O 2 to cause Fenton reaction and produce ·OH, thus mediating biotoxicity. 29 Therefore, the assessment of whether PTCN can undergo Fenton reaction was crucial for the correct evaluation of ROS-scavenging activity and the potential biosafety of PTCN. As shown in Figure S10 , the FeSO 4 and H 2 O 2 system has been considered a classic Fenton reaction model, and the produced ·OH could specifically react with salicylic acid to form 2,3-dihydroxybenzoic acid, exhibiting an obvious UV absorption peak at 510 nm.…”

Recent Trends in Composite Nanozymes and Their Pro-Oxidative Role in Therapeutics

“…Metal-based nanoparticles are well known to mimic POD and OXD activity, with promising applications in therapeutics. Metal-based nanozymes are in vogue owing to their easy synthesis and facile surface modification and convenience to hybridize with other elements and tailor their shape-size, high stability, biocompatibility, and electromagnetic functionality ( Li M. et al, 2020 ; Shi et al, 2020 ). For instance, Xi et al have shown that the doping of Cu in hollow carbon spheres (Cu-HCS) accelerated their POD activity ( Xi et al, 2019 ).…”

Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

“…With the discovery of the enzymatic properties of iron oxide nanoparticles (Fe3O4 NPs) and iron-based NPs (Au@Fe3O4 [54], Fe3O4 coated Ag [55], Pt48Pd52-Fe3O4 [56], Fe3O4@Pt [57], metal organic framework-based MnFe2O4/C nanozymes, [58], etc. ), new attention has focused on bioapplications of peroxidaselike Fe3O4 nanostructures [38,59]. For instance, cobalt-doped Magnetoferritin (M-HFn) NPs (M-HFn-Cox Fe3-x O4) with different amounts of cobalt were successfully synthesized.…”