Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Thangudu, Suresh; Su, Chia‐Hao

doi:10.3390/biom11071015

Cited by 49 publications

(27 citation statements)

References 112 publications

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“…The enzymatic action of nanoparticles can lead to significant altering of the TME through various known or perceived mechanisms that include catalyzing Fenton-type reactions, cleaving prodrugs to locally release toxic drugs, degrading tumor-promoting oncogenes, duplicating the action of enzymes such as CAT, etc. [ 74 , 75 , 76 ]. Such nanozyme-mediated TME modulation can lead either to direct killing of cancer cells or complement other therapies such as chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT).…”

Section: Nanozyme Platforms For Anticancer Applicationsmentioning

confidence: 99%

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

et al. 2022

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The ability of some nanoparticles to mimic the activity of certain enzymes paves the way for several attractive biomedical applications which bolster the already impressive arsenal of nanomaterials to combat deadly diseases. A key feature of such ‘nanozymes’ is the duplication of activities of enzymes or classes of enzymes, such as catalase, superoxide dismutase, oxidase, and peroxidase which are known to modulate the oxidative balance of treated cells for facilitating a particular biological process such as cellular apoptosis. Several nanoparticles that include those of metals, metal oxides/sulfides, metal–organic frameworks, carbon-based materials, etc., have shown the ability to behave as one or more of such enzymes. As compared to natural enzymes, these artificial nanozymes are safer, less expensive, and more stable. Moreover, their catalytic activity can be tuned by changing their size, shape, surface properties, etc. In addition, they can also be engineered to demonstrate additional features, such as photoactivated hyperthermia, or be loaded with active agents for multimodal action. Several researchers have explored the nanozyme-mediated oxidative modulation for therapeutic purposes, often in combination with other diagnostic and/or therapeutic modalities, using a single probe. It has been observed that such synergistic action can effectively by-pass the various defense mechanisms adapted by rogue cells such as hypoxia, evasion of immuno-recognition, drug-rejection, etc. The emerging prospects of using several such nanoparticle platforms for the treatment of bacterial infections/diseases and cancer, along with various related challenges and opportunities, are discussed in this review.

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Section: Nanozyme Platforms For Anticancer Applicationsmentioning

confidence: 99%

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

et al. 2022

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“…SAzyme with peroxidase activity (CAT) can oxidize endogenous H 2 O 2 to O 2 and alleviate cellular hypoxia. In addition, peroxidase activity can also catalyze the production of ROS, thus combining SAzyme with photodynamic therapy is a promising method for highly curative treatment of tumors [98] . Li Qiu′s group [31] synthesized a polymeric spherical nanozyme by self‐assembly reaction using 5,10,15,20‐tetrakis(4‐pyridyl) porphyrin and pyridine nitrogen‐containing substances as ligands and Pd atoms as linking sites.…”

Section: Biomedical Therapymentioning

confidence: 99%

“…In addition, peroxidase activity can also catalyze the production of ROS, thus combining SAzyme with photodynamic therapy is a promising method for highly curative treatment of tumors. [98] Li Qiu's group [31] synthesized a polymeric spherical nanozyme by self-assembly reaction using 5,10,15,20-tetrakis(4-pyridyl) porphyrin and pyridine nitrogen-containing substances as ligands and Pd atoms as linking sites. The POD-like enzymatic activity of this SAzyme can be significantly enhanced by ultrasound and light irradiation, resulting in favorable acoustodynamic and photodynamic therapeutic effects.…”

Section: Cancer Therapymentioning

confidence: 99%

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

Tang

Cai

et al. 2022

Chemistry An Asian Journal

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Nanozymes have received extensive attention in the fields of sensing and detection, medical therapy, industry, and agriculture thanks to the combination of the catalytic properties of natural enzymes and the physicochemical properties of nanomaterials, coupled with superior stability and ease of preparation. Despite the promise of nanozymes, conventional nanozymes are constrained by their oversized size and low catalytic capacity in sophisticated practical application environments. single-atom nanozymes (SAzymes) were characterized as nanozymes with high catalytic efficiency by uniformly distributed single atoms as catalysis sites, thus effectively addressing the defects of conventional nanozymes. This paper reviews the activity improvement scheme and catalytic mechanism of SAzymes and highlights the latest research progress of SAzymes in the fields of biomedical sensing and therapy. Eventually, the challenges and future directions of SAzymes are discussed in this paper.

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“…The repeated administration of large amounts of active agent may increases the potential toxicity to biosystem [ 19 ]. Moreover, CeNP showed additional advantages, such as high efficiency, high versatility, high stable, low costs, and minimal immunogenicity [ 21 ]. We previously demonstrated that CeNP exhibited neuroprotective effects by suppressing the proinflammatory responses of activated microglia [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

Zeng

Shi

et al. 2022

J Nanobiotechnol

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Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a lack of effective therapeutic strategies. The proinflammatory microenvironment plays a significant role in both amplifying and sustaining inflammation during IBD progression. Herein, biocompatible drug-free ceria nanoparticles (CeNP-PEG) with regenerable scavenging activities against multiple reactive oxygen species (ROS) were developed. CeNP-PEG exerted therapeutic effect in dextran sulfate sodium (DSS)-induced colitis murine model, evidenced by corrected the disease activity index, restrained colon length shortening, improved intestinal permeability and restored the colonic epithelium disruption. CeNP-PEG ameliorated the proinflammatory microenvironment by persistently scavenging ROS, down-regulating the levels of multiple proinflammatory cytokines, restraining the proinflammatory profile of macrophages and Th1/Th17 response. The underlying mechanism may involve restraining the co-activation of NF-κB and JAK2/STAT3 pathways. In summary, this work demonstrates an effective strategy for IBD treatment by ameliorating the self-perpetuating proinflammatory microenvironment, which offers a new avenue in the treatment of inflammation-related diseases. Graphical Abstract

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Peroxidase Mimetic Nanozymes in Cancer Phototherapy: Progress and Perspectives

Cited by 49 publications

References 112 publications

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

Single‐Atom Nanozymes for Biomedical Applications: Recent Advances and Challenges

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

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