Iron chelation and liver disease healing activity of edible mushroom (Cantharellus cibarius), in vitro and in vivo assays

Abstract

Methanolic and ethyl acetate extracts ofCantharellus cibariusshow significant iron chelation activities bothin vitroandin vivo. The methanolic extract is more efficient in chelation of excessive iron from plasma and liver.

Medicinal potential of extracts from the chanterelle mushroom, Cantharellus cibarius (Review) and prospects for studying its strains from differs plant communities of ultracontinental regions of the Asia

“…Iron-overloaded animals treated with the extract, showed a dramatic decrease in plasma iron content when compared with the control group. The highest activity was observed in the methanolic extract [13].…”

Purification and Structural Characterization of a Novel Water-Soluble Neutral Polysaccharide from Cantharellus cibarius and Its Immunostimulating Activity in RAW264.7 Cells

“…It incrementally attracted attention of researchers in the past decade for its high nutritional and medical value. It is rich in protein, carbohydrates, carotene, vitamin C, vitamin D, potassium, calcium, phosphorus, and other nutrients [18][19][20].…”

Studyng the effects of Cantharellus cibarius fungi on Opisthorchis felineus trematode and on parasite host - C57BL/6 inbred mice

“…In the present work, the first data on anthelminthic activity of C. cibarius extracts on a model of O. felineusinduced opisthorchiasis in mice was obtained. Earlier, antiinflammatory effects (Vamanu, Nita, 2014), insecticide activity (CienieckaRosłonkiewicz et al, 2007), antioxidant and hepatoprotective properties -decreased fibrotic liver changes associated with induced inflammation (Aina et al, 2012;Khalili et al, 2014Khalili et al, , 2015, as well as cytotoxic effects on cancer cells in vitro (Sari et al, 2017) for C. cibarius extracts were demonstrated. In view of the above, one might expect a possible inhibitory action of C. cibarius directly on helminths.…”

“…Methanolic fungi extract has an advantage over aqueous extract due to its antimicrobial effect (Kozarski et al, 2015;Muszyńska et al, 2016), while antimicrobial activity of methanolic extract against Escherichia coli is 7 times higher than ethanolic extract (Aina et al, 2012). Singledose or chronic intraperitoneal introduction of C. cibarius methanolic extracts are used for mice, the dose range -200-800 mg/kg (Khalili et al, 2014(Khalili et al, , 2015. No studies of C. cibarius efficacy in treating opisthorchiasis infections have been performed.…”