Iron chelation therapy in patients with low‐ to intermediate‐risk myelodysplastic syndrome: A systematic review and meta‐analysis

Cobalt chloride has beneficial effects across species through a hormetic mechanism

“…Indeed, while the potential therapeutic benefits of hypoxia preconditioning are evident and have been suggested ( Li et al, 2017 ; Caricati-Neto et al, 2019 ), fine-tuning oxygen levels to trigger beneficial effects without surpassing the critical threshold is not trivial and has low practical applications. Thus, the identification of more finely tunable interventions mimicking hypoxia, such as iron chelators already used in the clinic or undergoing clinical trials ( Wijesinghe et al, 2021 ; Yang et al, 2021 ; Reddy et al, 2022 ) or modulators of downstream molecular players mediating their beneficial effects, may suggest more practicable strategies to interfere with the detrimental features associated with aging and severe hypoxia. Different phenotypic features are concurrently associated with the pro-longevity effect induced by mild doses of CoCl 2 such as reduced animals’ size and egg-lay rate, prolonged fertility period, and increased resistance to stress ( Ventura et al, 2005 ; Rea et al, 2007 ) and delayed neuromuscular decline during aging ( Maglioni et al, 2014 ), which strikingly resemble those induced by mild mitochondrial stress.…”