2012
DOI: 10.1007/s12011-012-9548-9
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Iron Excess Disturbs Metabolic Status and Relative Gonad Mass in Rats on High Fat, Fructose, and Salt Diets

Abstract: The aim of this study was to assess the metabolic and physiological changes in rats fed a diet high in fat, fructose, and salt, and with excess iron level. Mineral status was also estimated. Wistar rats were assigned to groups fed either a standard control diet (C) or a diet high in fat, fructose, and salt. The noncontrol diets contained either normal (M) or high level (MFe) of iron. After 6 weeks, the length and weight of the rats were measured, and the animals were euthanized. The kidneys and gonads were col… Show more

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Cited by 6 publications
(3 citation statements)
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“…It suggests that the type of nutrition can influence mass of investigated organs. Similar observations (relative organ mass) but for gonad or pancreas mass and for iron were reported by Suliburska et al [ 45 , 46 ].…”
Section: Discussionsupporting
confidence: 89%
“…It suggests that the type of nutrition can influence mass of investigated organs. Similar observations (relative organ mass) but for gonad or pancreas mass and for iron were reported by Suliburska et al [ 45 , 46 ].…”
Section: Discussionsupporting
confidence: 89%
“…Research have proven that an 8-week HSD caused both exocrine and endocrine pancreatic insufficiency in rats, which significantly decreased plasma levels of α-amylase and lipase, insulin while significantly increasing TGF-β1 and IL6, resulting in pancreatic fibrosis [26]. An insulin decrease has also been observed with HSD-fed Wistar rats [26,51]. HSD-induced insulin resistance (IR) was found to be driven by impaired microvascular responsiveness to insulin [52] and linked with decreased insulin sensitivity, phosphatidylinositol (PI) 3-kinase or Akt activation [53], and AT hypoxia [54].…”
Section: Hsd and Gi Hormonesmentioning
confidence: 99%
“…Iron overload is a risk factor for renal dysfunction, hypogonadism [17, 18], and diabetes [19]. In rats, high iron intake leads to increased gonad mass [20]. Iron interacts with copper and zinc [21], which are important components of a range of enzymes [22, 23]; disturbances in the metabolism of these three minerals frequently coexist [21].…”
Section: Introductionmentioning
confidence: 99%