Iron homeostasis in breast cancer

Marques, Oriana; Silva, Ana Martins; Porto, Graça; Lopes, Carlos

doi:10.1016/j.canlet.2014.01.029

Cited by 95 publications

(87 citation statements)

References 310 publications

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“…MYC is a key regulator of iron metabolism and upregulates genes in this pathway (15). An increased expression of iron metabolism genes in breast cancer cell lines with an aggressive mesenchymal phenotype has been described (54) and may indicate increased MYC signaling. We did not find that MYC induces ADHFE1 through a direct mechanism, suggesting that the effect of MYC on iron metabolism is a primary driver of MYC-induced ADHFE1.…”

Section: +mentioning

confidence: 99%

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

Mishra

Tang

Putluri

et al. 2017

Journal of Clinical Investigation

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Section: +mentioning

confidence: 99%

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

Mishra

Tang

Putluri

et al. 2017

Journal of Clinical Investigation

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“…However, it is still controversial about the causality of shorter telomeres and aging. Moreover, carcinogenesis and aging process also associate with impaired iron absorption, storage and utilization, as well as abnormal protein levels or activities of some iron-containing proteins (Marques et al, 2014). This suggests a correlation between iron homeostasis and telomere length ( Fig.…”

Section: Telomeres Cancer Aging and Ironmentioning

confidence: 97%

“…Iron is considered to associate with carcinogenesis, either through inducing ROS generation or due to its critical roles in cellular proliferation (Marques et al, 2014). Experimental analyses indicate that iron induced oxidative stress may damage DNA, protein and organelle (Tang et al, 2011).…”

Section: Telomeres Cancer and Ironmentioning

confidence: 99%

“…For instance, iron is required for both tumor initiation and growth (Torti S V and Torti F M, 2013). The iron uptake, storage and regulation pathways participate in carcinogenesis (Lamy et al, 2014;Marques et al, 2014;Wang et al, 2014), suggesting the critical roles of iron homeostasis in tumor cell survival. Signal transduction through hypoxia-inducible factor (HIF) and Wnt pathways possibly contributes to disruption of iron homeostasis in cancer (Torti S V and Torti F M, 2013).…”

Section: Introductionmentioning

confidence: 99%

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The correlation between iron homeostasis and telomere maintenance

Zhang

2014

Front. Biol.

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Eukaryotic organisms require iron to sustain genome stability, cell proliferation and development. Chromosomes contain telomeres to ensure complete replications and avoid fusions. Numerous evidences reveal that iron can act directly or indirectly on telomere maintenance. In human, disruption of systemic or cellular iron homeostasis is reportedly to cause serious health problems such as iron overload (hereditary hemochromatosis), iron deficiency anemia, carcinogenesis and acceleration of aging process. These processes commonly associate with abnormal telomere length. Additionally, cells containing mutations in iron-containing proteins such as DNA polymerases (Polα, δ, and ε), regulator of telomere length 1 (RTEL1) and the small subunit of ribonucleotide reductases (RNRs) have abnormal telomere length. This review briefly summarizes current understandings on iron homeostasis and telomere maintenance in cancer and aging process, followed by discussing their direct and indirect correlation, and the possible regulatory mechanisms.

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“…Iron is a cofactor for ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides for the synthesis and repair of DNA. a crucial element in DNA synthesis, and a constant supply of iron is required to maintain DNA activity [12]. Being highly proliferative, tumour cells need more iron and they usually show high intracellular iron concentration [13,14].…”

Section: Discussionmentioning

confidence: 99%

Changes in Serum Iron, Total Iron Binding Capacity and Transferrin Saturation Percent in Sudanese Females Newly Diagnosed with Breast Cancer at Khartoum Oncology Hospital: A case- control study

Mustafa

Husain

2017

SJMS

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Background: Iron is a vital constituent of cells but in excess may be harmful and is associated with a raised risk for some malignant diseases including breast cancer. We aimed to study changes in iron profile in Sudanese females newly diagnosed with breast cancer. Methods: A case-control study in which serum iron, Total Iron Binding Capacity (TIBC), and transferrin saturation percent were measured for fifty females with breast cancer referred to Khartoum Oncology Hospital and seventy apparently healthy females, using manual method (IRON-FERROZINE). Results: Mean age was 47 years and 42 years in cases and control, respectively and the mean of parity was 4 in both groups. Mean of serum iron ±SD in case group was 244.30 ± 151.598( g/dL) and in control group was 57.59 ± 43.191( g/dL) (P. value = 0.000). Mean of TIBC ±SD in cases was 412.98 ± 177.460( g/dL) and in controls it was 403.71 ± 168.765( g/dL) (P. value = 0.838). The mean of transferrin saturation percent ± SD in cases was 61.08 % ±41.523 and in controls was 223.23 % ±149.195 (P. value=0.000). The mean of TIBC in grade I 343.00( g/dL), 467.10( g/dL) in grade II and 321.25( g/dL) in grade III (P. value 0.019) according to Modified Bloom Richardson's grading system. Conclusion: There is a statistically significant increase in the mean of serum iron and decrease in transferrin saturation percent in women with breast cancer. TIBC vary significantly according to histopathological grade. Serum iron and transferrin saturation percent may be helpful as biochemical risk markers for breast cancer and TIBC may act as a predictor of disease grade.

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Iron homeostasis in breast cancer

Cited by 95 publications

References 310 publications

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

ADHFE1 is a breast cancer oncogene and induces metabolic reprogramming

The correlation between iron homeostasis and telomere maintenance

Changes in Serum Iron, Total Iron Binding Capacity and Transferrin Saturation Percent in Sudanese Females Newly Diagnosed with Breast Cancer at Khartoum Oncology Hospital: A case- control study

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