Iron Homeostasis in Full Term, Normal Birthweight Gambian Neonates Over the First Week of Life

Cross, James H.; Jarjou, Ousman; Mohammed, Nuredin; Rayment-Gomez, Santiago; Touray, Bubacarr J B; Prentice, Andrew M.; Cerami, Carla

doi:10.2139/ssrn.3777134

Cited by 1 publication

(1 citation statement)

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“…Hepcidin, a liver-derived peptide hormone, maintains iron homeostasis in the body. Studies have shown that hepcidin ubiquitinates ferroportin (FPN) and reduces its activity, thus lowering iron concentrations (116,117) Patients with sepsis have significantly higher concentrations of hepcidin. Expression of hepcidin is induced by IL-6 and IL-1β when inflammation takes place (118).…”

Section: Association Between Cell Death and Scmentioning

confidence: 99%

Sepsis‑induced cardiac dysfunction and pathogenetic mechanisms (Review)

Song,

Fang,

Zhou

et al. 2023

Mol Med Rep

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Sepsis is a manifestation of the immune and inflammatory response to infection, which may lead to multi-organ failure. Health care advances have improved outcomes in critical illness, but it still remains the leading cause of death. Septic cardiomyopathy is heart dysfunction brought on by sepsis. Septic cardiomyopathy is a common consequence of sepsis and has a mortality rate of up to 70%. There is a lack of understanding of septic cardiomyopathy pathogenesis; knowledge of its pathogenesis and the identification of potential therapeutic targets may reduce the mortality rate of patients with sepsis and lead to clinical improvements. The present review aimed to summarize advances in the pathogenesis of cardiac dysfunction in sepsis, with a focus on mitochondrial dysfunction, metabolic changes and cell death modalities and pathways. The present review summarized diagnostic criteria and outlook for sepsis treatment, with the goal of identifying appropriate treatment methods for this disease.

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Section: Association Between Cell Death and Scmentioning

confidence: 99%