Iron, hormesis, and protection in acute kidney injury

Swaminathan, Sundararaman

doi:10.1016/j.kint.2016.02.035

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…Catalytic iron, also known as LPI, is a transitional pool of NTBI. It readily participates in redox cycling and causes damage to cell membranes, proteins, and DNA through redox reaction such as the Fenton reaction [ 9 , 13 , 14 ]. The role of catalytic iron as a critical player in different types of AKI has been demonstrated in many animal models [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury

Shu

et al. 2020

BMC Nephrol

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Background Accumulation of iron is associated with oxidative stress, inflammation, and regulated cell death processes that contribute to the development of acute kidney injury (AKI). We aimed to investigate the association between serum iron levels and prognosis in intensive care unit (ICU) patients with AKI. Methods A total of 483 patients with AKI defined as per the Kidney Disease: Improving Global Guidelines were included in this retrospective study. The data was extracted from the single-centre Medical Information Mart for Intensive Care III database. AKI patients with serum iron parameters measured upon ICU admission were included and divided into two groups (low group and high group). The prognostic value of serum iron was analysed using univariate and multivariate Cox regression analysis. Results The optimal cut-off value for serum iron was calculated to be 60 μg/dl. Univariable Cox regression analysis showed that serum iron levels were significantly correlated with prognosis of AKI patients. After adjusting for possible confounding variables, serum iron levels higher than 60 μg/dl were associated with increases in 28-day (hazard [HR] 1.832; P < 0.001) and 90-day (HR 1.741; P < 0.001) mortality, as per multivariable Cox regression analysis. Conclusions High serum iron levels were associated with increased short- and long-term mortality in ICU patients with AKI. Serum iron levels measured upon admission may be used for predicting prognosis in AKI patients.

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Section: Discussionmentioning

confidence: 99%

Elevated serum iron level is a predictor of prognosis in ICU patients with acute kidney injury

Shu

et al. 2020

BMC Nephrol

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“…SD standard deviation, HLA Human leukocyte antigen, eGFR estimated glomerular filtration rate, TSAT transferrin saturation, CRP c-reactive protein. www.nature.com/scientificreports/ participating in the redox cycles [25][26][27] . Oxidative stress through the Fenton reaction impairs proteins, deoxyribonucleic acid, and cell membranes.…”

Section: Discussionmentioning

confidence: 99%

Impact of iron status on kidney outcomes in kidney transplant recipients

Kim

Kang

et al. 2023

Sci Rep

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Iron plays an important role in hemodynamics and the immunity, independent of anemia. Since dynamic changes occur in iron storage after kidney transplantation (KT), we investigated the association between iron status and kidney outcomes in KT patients. We analyzed data from the KoreaN cohort study for Outcome in patients With KT (KNOW-KT). The iron status was classified into three groups based on ferritin or transferrin saturation (TSAT) levels one year after KT, with reference ranges of 20‒35% and 100‒300 ng/mL for TSAT and ferritin, respectively. The primary outcome was the composite outcome, which consisted of death, graft failure, and an estimated glomerular filtration rate decline ≥ 50%. In total, 895 patients were included in the final analysis. During a median follow-up of 5.8 years, the primary outcome occurred in 94 patients (19.8/1000 person-years). TSAT levels decreased one year after KT and thereafter gradually increased, whereas ferritin levels were maintained at decreased levels. The adjusted hazard ratios (95% confidence intervals) for the composite outcome were 1.67 (1.00–2.77) and 1.20 (0.60–2.40) in the TSAT > 35% and ferritin > 300 ng/mL groups, respectively. High iron status with high TSAT levels increases the risk of graft failure or kidney functional deterioration after KT.

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“…Catalytic iron, labile iron, was a transitional pool of non-transferrin bound iron (NTBI). It readily participated in redox cycle and caused damage to cell membranes, proteins and DNA through redox reaction such as Fenton reaction [5][6][7]. The catalytic iron as a critical player in different types of AKI was demonstrated in many animal models [8,9].…”

Section: Discussionmentioning

confidence: 99%