Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy

Zhou, Zhiguo; Sun, Yanan; Shen, Jinchao; Wei, Jie; Chao, Yu; Kong, Bin; Liu, Wei; Yang, Hong; Yang, Shiping; Wang, Wei

doi:10.1016/j.biomaterials.2014.04.063

Cited by 272 publications

(191 citation statements)

References 47 publications

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“…The gold-coated IONPs with cisplatin exhibited up to 110-fold higher toxicity than cisplatin in those cancer cell lines. Moreover, in response to a laser irradiation, the PEGylated iron, iron/iron oxide core/shell nanoparticles (Fe@Fe 3 O 4 NPs) were able to generate a stronger effect in tumor cell killing both in vitro and in vivo by photothermal therapy [86]. Furthermore, photodynamic therapy involved in nanoparticles conjugated with photosensitizers that could be activated by specific wavelength of light and then produced ROS to kill tumor cells [87].…”

Section: Theranostic Applications Of Magnetic Nanoparticles In Cancermentioning

confidence: 99%

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Zhu

Zhou

Mao

et al. 2016

Nanomedicine (Lond.)

242

147

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Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal-or photodynamic response. In this review, we provide an overview of the physicochemical properties, toxicity and theranostic applications of MNPs with a focus on magnetic iron oxide nanoparticles.

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Section: Theranostic Applications Of Magnetic Nanoparticles In Cancermentioning

confidence: 99%

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Zhu

Zhou

Mao

et al. 2016

Nanomedicine (Lond.)

242

147

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“…74 Currently, new PEGylated Fe@Fe 3 O 4 NP structures have shown strong photothermal conversion efficiency (~20%) (Figure 7c). 75 The presence of a metallic Fe core could increase the magnetization for magnetic targeting applications and the transverse relaxivity, which could lead to the development of combined photomedicine and theranostics with Fe 3 O 4 -based nanoreagents.…”

Section: Fe 3 O 4 Nanostructuresmentioning

confidence: 99%

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

et al. 2016

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With the development of nonlinear optics and new imaging methods, near-infrared (NIR) light can excite contrast agents to probe biological specimens both functionally and structurally with a deeper imaging depth and a higher spatial resolution than linear optical approaches. There is considerable and growing interest in how biological specimens respond to NIR light. Moreover, the visible absorption band of most functional nanomaterials becomes NIR-excitable through multiphoton processes, thus allowing multifunctional imaging and combined therapy with noble metal and magnetic nanoparticles both in vitro and in vivo. A groundbreaking example is the use of different laser techniques to excite single-type NIR-absorbing/emitting nanomaterials to produce multiphoton emission by femtosecond lasers using either a remote control system for photodynamic therapy or photo-induced chemical bond dissociation. These techniques provided superior anatomical resolution and detection sensitivity for in vivo tumor-targeted imaging than those offered by conventional methods. Here we summarize the most recent progress in the development of smart NIR-absorbing/emitting nanomaterials for in vivo bioapplications.

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“…It provides a wealth of physiological and anatomical information on healthy or diseased internal organs and tissues. 18,19 Superparamagnetic iron oxide nanoparticles (NPs), such as Fe 3 O 4 NPs, are strong enhancers of proton relaxation with superior magnetic resonance (MR) T 2 (transverse relaxation) shortening effects and can be used at a much lower concentration than paramagnetic agents. 20,21 When synthesizing multifunctional magnetic and luminescent nanomaterials, we found that the luminescence intensity of luminescent labels dropped when coupled directly to Fe 3 O 4 NPs.…”

Section: Zhou Et Almentioning

confidence: 99%

Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging

Zhou¹,

Jia²,

Luo³

et al. 2016

IJN

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A novel multifunctional halloysite nanotube (HNT)-based Fe 3 O 4 @HNT-polyethyleneimine-Tip-Eu(dibenzoylmethane) 3 nanocomposite (Fe-HNT-Eu NC) with both photoluminescent and magnetic properties was fabricated by a simple one-step hydrothermal process combined with the coupling grafting method, which exhibited high suspension stability and excellent photophysical behavior. The as-prepared multifunctional Fe-HNT-Eu NC was characterized using various techniques. The results of cell viability assay, cell morphological observation, and in vivo toxicity assay indicated that the NC exhibited excellent biocompatibility over the studied concentration range, suggesting that the obtained Fe-HNT-Eu NC was a suitable material for bioimaging and biological applications in human hepatic adenocarcinoma cells. Furthermore, the biocompatible Fe-HNT-Eu NC displayed superparamagnetic behavior with high saturation magnetization and also functioned as a magnetic resonance imaging (MRI) contrast agent in vitro and in vivo. The results of the MRI tests indicated that the Fe-HNT-Eu NC can significantly decrease the T 2 signal intensity values of the normal liver tissue and thus make the boundary between the normal liver and transplanted cancer more distinct, thus effectively improving the diagnosis effect of cancers.

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Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy

Cited by 272 publications

References 47 publications

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Revisiting the classification of NIR-absorbing/emitting nanomaterials for in vivo bioapplications

Multifunctional nanocomposite based on halloysite nanotubes for efficient luminescent bioimaging and magnetic resonance imaging

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