Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Zhu, Lei; Zhou, Zhiyang; Mao, Hui; Yang, Lily

doi:10.2217/nnm-2016-0316

Cited by 242 publications

(150 citation statements)

References 116 publications

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“…The studies revealed safe doses for administration (2.9 mg Fe per kg in humans), while it was previously demonstrated that NPs with 30 nm in size were uptaken by the macrophages in the spleen, liver, and lymph nodes . Magnetic‐iron‐based NPs thus will likely show lower safety concerns than other nanomaterials for the translational development of new theranostic agents for image‐guided and targeted cancer therapeutic approaches …”

Section: Magnetic Npsmentioning

confidence: 94%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

548

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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Section: Magnetic Npsmentioning

confidence: 94%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

548

330

View full text Add to dashboard Cite

show abstract

“…The technological progress regarding synthesis, characterization, biocompatibility and cytotoxicity of MNPs is evident, revealing positive advances in terms of quality, stability and applicability of these nano-sized platforms for imaging, diagnosis and treatment purposes. Despite the potential benefits of MNPs and their favourable outcomes for biomedical and theranostic applications, some fundamental points still require the researchers' attention [113].…”

Section: Future Challengesmentioning

confidence: 99%

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

2020

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Technological development is in constant progress in the oncological field. The search for new concepts and strategies for improving cancer diagnosis, treatment and outcomes constitutes a necessary and continuous process, aiming at more specificity, efficiency, safety and better quality of life of the patients throughout the treatment. Nanotechnology embraces these purposes, offering a wide armamentarium of nanosized systems with the potential to incorporate both diagnosis and therapeutic features, towards real-time monitoring of cancer treatment. Within the nanotechnology field, magnetic nanosystems stand out as complex and promising nanoparticles with magnetic properties, that enable the use of these constructs for magnetic resonance imaging and thermal therapy purposes. Additionally, magnetic nanoparticles can be tailored for increased specificity and reduced toxicity, and functionalized with contrast, targeting and therapeutic agents, revealing great potential as multifunctional nanoplatforms for application in cancer theranostics. This review aims at providing a comprehensive description of the current designs, characterization techniques, synthesis methods, and the role of magnetic nanoparticles as promising nanotheranostic agents. A critical appraisal of the impact, potentialities and challenges associated with each technology is also presented.

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“…Local retention of nanocomposites may prolong the half-life of the drug, enhance therapeutic efficacy, and reduce systemic adverse effects. [3][4][5] Application of a static magnetic field enhances MNP uptake by cultured cells, primarily by enhancing the sedimentation rate of MNPs. 6 The subsequent interaction between the cell and the NP is also important for cellular uptake, which may impact pharmacological efficacy.…”

Section: Introductionmentioning

confidence: 99%

Interaction of poly-L-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells

Siow¹,

Chang²,

Babič³

et al. 2018

IJN

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BackgroundPoly-l-lysine (PLL) enhances nanoparticle (NP) uptake, but the molecular mechanism remains unresolved. We asked whether PLL may interact with negatively charged glycoconjugates on the cell surface and facilitate uptake of magnetic NPs (MNPs) by tumor cells.MethodsPLL-coated MNPs (PLL-MNPs) with positive and negative ζ-potential were prepared and characterized. Confocal and transmission electron microscopy was used to analyze cellular internalization of MNPs. A colorimetric iron assay was used to quantitate cell-associated MNPs (MNPcell).ResultsCoadministration of PLL and dextran-coated MNPs in culture enhanced cellular internalization of MNPs, with increased vesicle size and numbers/cell. MNPcell was increased by eight- to 12-fold in response to PLL in a concentration-dependent manner in human glioma and HeLa cells. However, the application of a magnetic field attenuated PLL-induced increase in MNPcell. PLL-coating increased MNPcell regardless of ζ-potential of PLL-MNPs, whereas magnetic force did not enhance MNPcell. In contrast, epigallocatechin gallate and magnetic force synergistically enhanced PLL-MNP uptake. In addition, heparin, but not sialic acid, greatly reduced the enhancement effects of PLL; however, removal of heparan sulfate from heparan sulfate proteoglycans of the cell surface by heparinase III significantly reduced MNPcell.ConclusionOur results suggest that PLL-heparan sulfate proteoglycan interaction may be the first step mediating PLL-MNP internalization by tumor cells. Given these results, PLL may facilitate NP interaction with tumor cells via a molecular mechanism shared by infection machinery of certain viruses.

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Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Cited by 242 publications

References 116 publications

Advances in Magnetic Nanoparticles for Biomedical Applications

Advances in Magnetic Nanoparticles for Biomedical Applications

The Role of Magnetic Nanoparticles in Cancer Nanotheranostics

Interaction of poly-L-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells

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