Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence

Sukiennicki, Grzegorz; Marciniak, Wojciech; Muszyńska, Magdalena; Baszuk, Piotr; Gupta, Satish; Białkowska, Katarzyna; Jaworska–Bieniek, Katarzyna; Durda, Katarzyna; Lener, Marcin; Pietrzak, S.; Gromowski, Tomasz; Prajzendanc, Karolina; Łukomska, Alicja; Waloszczyk, Piotr; Wójcik, Janusz; Scott, Rodney J.; Lubiński, Jan; Jakubowska, Anna

doi:10.1371/journal.pone.0208610

Cited by 50 publications

(52 citation statements)

References 37 publications

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“…In pregnancy, and especially in severe inflammations, the interpretation of iron concentration results may be difficult [1,27]. Ferritin is considered an indicator of iron storage concentrations, but at the same time is an acute phase protein and its level increases in inflammation [28,29]. Correlations of iron concentrations with hepcidin levels have also been studied in recent years [1,30].…”

Section: Discussionmentioning

confidence: 99%

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

2019

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The aim of this study was to assess the relationship between serum iron concentrations in early healthy pregnancy and the risk of pregnancy-induced hypertension. The data comes from our prospective cohort study in which we recruited healthy women in week 10–14 of single pregnancy. We examined a study group (n = 121) consisting of women subsequently developing pregnancy-induced hypertension and a control group (n = 363) of matched women remaining normotensive. We measured iron concentrations in the serum collected in 10–14 gestational week, using the ICP-MS technique (mass spectrometry with inductively coupled plasma). The odds ratios of the disease (95% confidence intervals) for iron concentrations were assessed in multivariate logistic regression. We found that the mean microelement concentration was lower in the case group compared to normotensive controls (p = 0.011). Women in the lowest quartile of iron (≤801.20 µg/L) had a 2.19-fold increase in pregnancy-induced hypertension risk compared with women in the highest quartile (>1211.75 µg/L) (odds ratio (OR) = 2.19; 95% CI: 1.24–3.88; p = 0.007). This result was sustained after adjusted for all the accepted confounders. Women in the higher Q2 quartile (801.20–982.33 µg/L) had a 17% lower risk, compared with those in the highest quartile (OR = 0.83; 95% CI: 0.65–2.32; p = 0.519).

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Section: Discussionmentioning

confidence: 99%

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

2019

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“…This has made it a desirable target for cancer treatment and prevention. 19 Previous studies have shown that iron metabolism may contribute to certain cancers, including lung cancer, 20 leukemia, 21 prostate cancer, 22 and kidney cancer. 23 However, the prognostic signature of iron metabolism in GC needs to be adequately explored.…”

Section: Discussionmentioning

confidence: 99%

<p>An Iron Metabolism-Related <em>SLC22A17</em> for the Prognostic Value of Gastric Cancer</p>

Wei¹,

Gao²,

Qin³

et al. 2020

OTT

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Purpose Gastric cancer (GC) is a type of malignant cancer with a poor prognosis. The iron’s metabolism plays an important role in the process of GC. The aim of this study was to evaluate the effectiveness of SLC22A17 , associated with iron metabolism, in predicting the prognosis of GC patients. Materials and Methods We analyzed genes related to iron metabolism of gastric cancer mRNA-seq data from TCGA database. We identified an iron metabolism-related SLC22A17 as an independent prognostic factor using univariate and multivariate Cox regression analysis. Results Further research showed that SLC22A17 was related with many pathways involved in the process of gastric cancer, and the expression was associated with diverse cancer-infiltrating immune cells. The expression of SLC22A17 was associated with T (Topography). Conclusion We validated that SLC22A17 associated with iron metabolism could serve as a prognostic biomarker for GC patients.

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“…Hodgkin's lymphoma, lung, colorectal, pancreatic and breast cancers are also affected by this increase [49][50][51][52][53][54][55][56][57]. This ferritin increase is a reliable prognostic biomarker for ovary, lung and breast cancers [44,58,59].…”

Section: Iron and Fe-proteins As Cancer Biomarkersmentioning

confidence: 97%

Iron Dysregulation in Human Cancer: Altered Metabolism, Biomarkers for Diagnosis, Prognosis, Monitoring and Rationale for Therapy

Lelièvre

Sancey

Coll

et al. 2020

Preprint

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Iron (Fe) is a trace element that plays essential roles in various biological processes such as DNA synthesis and repair, as well as cellular energy production, or oxygen transport, and it is currently widely recognized that iron homeostasis is dysregulated in many cancers. Indeed, several iron homeostasis proteins may be responsible for malignant tumor initiation, proliferation, and for metastatic spread of tumors. A large number of studies demonstrated the potential clinical value of turning these deregulated proteins as prognostic and/or predictive biomarkers of malignancy and /or response to anticancer treatments. Additionally, the iron addiction of cancer cells and the importance of iron in ferroptosis cell death signaling pathways prompted the development of therapeutic strategies against advanced stage or resistant cancers. In this review, we selected relevant and promising studies in the field of iron metabolism in cancer research and clinical oncology. Besides, we discuss some co-existing discrepant findings. We will also present and discuss the latest lines of research related to targeting iron, or its regulatory pathways, as potential promising anti-cancer strategies for human therapy. Iron chelators, such as deferoxamine or iron-oxide based nanoparticles, which are already tested in clinical trials, alone or in combination with chemotherapy will also be reported.

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Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence

Cited by 50 publications

References 37 publications

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

Can Serum Iron Concentrations in Early Healthy Pregnancy Be Risk Marker of Pregnancy-Induced Hypertension?

<p>An Iron Metabolism-Related <em>SLC22A17</em> for the Prognostic Value of Gastric Cancer</p>

Iron Dysregulation in Human Cancer: Altered Metabolism, Biomarkers for Diagnosis, Prognosis, Monitoring and Rationale for Therapy

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