Iron metabolism and the risk of Restless Legs Syndrome in an elderly general population - The MEMO-Study

Berger, Klaus; Eckardstein, Arnold von; Trenkwalder, Claudia; Rothdach, Andreas; Junker, Ralf; Weiland, Stephan K.

doi:10.1007/s00415-002-0805-2

Cited by 135 publications

(95 citation statements)

References 12 publications

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“…This seems to be a rare and somewhat questionable condition in menstruating women and associated with fatigue, psychologic lability, restless leg, sleep disturbances, headache and neck pain, and a serum ferritin level Ͻ50 ng/ml but no overt anemia. This condition seems to improve with Fe supplementation (24,25).…”

Section: The Molecule Ferritinmentioning

confidence: 99%

The Fascinating but Deceptive Ferritin

Kalantar‐Zadeh

Kalantar‐zadeh

Lee

2006

Clinical Journal of the American Society of Nephrology

176

162

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Although the emergence of erythropoiesis-stimulating agents has revolutionized the anemia management of chronic kidney disease (CKD) in the past two decades, strategies to assess iron (Fe) status and to provide Fe supplementation have remained indistinct. The reported cases of hemochromatosis in dialysis patients from the pre-erythropoiesis-stimulating agent era along with the possible associations of Fe with infection and oxidative stress have fueled the "iron apprehension." To date, no reliable marker of Fe stores in CKD has been agreed on. Serum ferritin continues to be the focus of attention. Almost half of all maintenance hemodialysis patients have a serum ferritin >500 ng/ml. In this ferritin range, Fe supplementation currently is not encouraged, although most reported hemochromatosis cases had a serum ferritin >2000 ng/ml. The moderate-range hyperferritinemia (500 to 2000 ng/ml) seems to be due mostly to non-Fe-related conditions, including inflammation, malnutrition, liver disease, infection, and malignancy. Recent epidemiologic studies have shown that a low, rather than a high, serum Fe is associated with a poor survival in maintenance hemodialysis patients. In multivariate adjusted models that mitigate the confounding effect of malnutrition-inflammation, serum ferritin <1200 ng/ml and Fe saturation ratio in 30 to 50% range are associated with the greatest survival in maintenance hemodialysis patients. Although ferritin is a fascinating molecule, moderate hyperferritinemia is a misleading marker of Fe stores in patients with CKD. It may be time to revisit the utility of serum ferritin in CKD and ask ourselves whether its measurement has helped us or has caused more confusion and controversy.

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Section: The Molecule Ferritinmentioning

confidence: 99%

The Fascinating but Deceptive Ferritin

Kalantar‐Zadeh

Kalantar‐zadeh

Lee

2006

Clinical Journal of the American Society of Nephrology

176

162

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“…RLS assessment was done in faceto-face interviews with a short questionnaire that had been previously validated against physician classification [3] and had already been used in identical form in two other German studies [2,9]. In brief, the following questions were used according to the minimal criteria published by the International Restless Legs Syndrome Study Group [1]: 1) Do you have sensory discomfort like tingling, crawling with ants or pain in the legs associated with an urge to move?…”

Section: ■ Subjectsmentioning

confidence: 99%

Treatment wish of individuals with known and unknown restless legs syndrome in the community

et al. 2008

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“…Apesar disso, Berger et al 17 não encontraram relação entre os níveis de ferritina e transferrina e a prevalência de SPI na população idosa. Além disso, essa associação não foi adequadamente explorada nos estudos selecionados.…”

Section: Resultsunclassified

Prevalência de síndrome das pernas inquietas em pacientes com demência: uma atualização

Ribeiro

Novaes

Faleiros

et al. 2016

J. bras. psiquiatr.

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RESUMOObjetivo: Realizar uma revisão atualizada para avaliar a prevalência de síndrome das pernas inquietas e/ou movimentos periódicos dos membros em pacientes com demência, além de discutir dados sobre possíveis fatores de risco desses transtornos. Métodos: A revisão foi realizada utilizando a base de dados do PubMed, com o seguinte cruzamento de descritores: (dementia, Alzheimer's disease, dementia with Lewy's body or frontotemporal dementia) e (restless legs syndrome or periodic leg movements). Resultados: Foram selecionados sete artigos, os quais encontraram prevalência de síndrome das pernas inquietas, que variou de 4% a 24% em idosos com demência. Houve diferenças importantes entre os métodos utilizados para o diagnóstico, tamanho das amostras e causas de demência estudadas. Conclusão: Mais estudos com o objetivo de refinar os critérios diagnósticos e definir fatores de risco, especialmente relacionadas a idosos com demência, são necessários. Além disso, deve-se ficar atento a essa comorbidade na prática clínica. ABSTRACTObjective: To perform an updated review to assess the prevalence of restless legs syndrome and/or periodic limb movements in patients with dementia, besides the discussion about possible risk factors of these disorders. Methods: A review was performed using the PubMed database, crossing the following descriptors: (dementia, Alzheimer's disease, dementia with Lewy's body or frontotemporal dementia) and (restless legs syndrome or periodic leg movements). Results: We selected seven articles according to the inclusion and exclusion criteria. The prevalence of restless legs syndrome in elderly patients with dementia ranged from 4% to 24%. There were important differences in the method used to diagnose, sample size and causes of dementia. Conclusion: More studies are necessary to refine the diagnostic criteria and to define risk factors, especially related to elderly patients with dementia. In addition, the health professionals need to pay attention to this comorbidity in clinical practice.

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Iron metabolism and the risk of Restless Legs Syndrome in an elderly general population - The MEMO-Study

Abstract: No evidence was found that iron or ferritin deficiency are a major cause of RLS in this population study. The results support the hypothesis that changes in the complex regulation of iron metabolism contribute to the occurence of RLS.

Cited by 135 publications

References 12 publications

The Fascinating but Deceptive Ferritin

The Fascinating but Deceptive Ferritin

Treatment wish of individuals with known and unknown restless legs syndrome in the community

Prevalência de síndrome das pernas inquietas em pacientes com demência: uma atualização

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