Iron metabolism, free radicals, and oxidative injury

Emerit, J; Beaumont, Carole; Trivin, F

doi:10.1016/s0753-3322(01)00068-3

Cited by 403 publications

(300 citation statements)

References 37 publications

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“…They are all called oxygen free radicals. Highly reactive hydroxyl radical production, previously demonstrated in an in vivo model of iron-overloaded rats (45), is capable of widespread damage to cellular lipids, proteins, sugar and DNA (46).…”

Section: Mechanisms Of Iron Toxicity Free Radical-mediated Iron Toxicitymentioning

confidence: 82%

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Lekawanvijit

Chattipakorn

2009

Canadian Journal of Cardiology

106

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Section: Mechanisms Of Iron Toxicity Free Radical-mediated Iron Toxicitymentioning

confidence: 82%

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Lekawanvijit

Chattipakorn

2009

Canadian Journal of Cardiology

106

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“…Various substances capable of producing superoxide radicals can induce the oxidative potential of iron, since the metabolism of iron and the superoxide are interconnected. Elevated production of superoxide anions increases the release of free iron (Emerit et al, 2001). The deleterious effects of iron include DNA damage, lipid peroxidation (LPO), and oxidation of proteins (Valko et al, 2005).…”

Section: Mechanisms Of Metal-induced Oxidative Damagementioning

confidence: 99%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med.

323

123

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ABSTRACT:This review summarizes the current knowledge on the contribution of metals to the development of oxidative stress in fish. Metals are important inducers of oxidative stress in aquatic organisms, promoting formation of reactive oxygen species through two mechanisms. Redox active metals generate reactive oxygen species through redox cycling, while metals without redox potential impair antioxidant defences, especially that of thiol-containing antioxidants and enzymes. Elevated levels of reactive oxygen species lead to oxidative damage including lipid peroxidation, protein and DNA oxidation, and enzyme inactivation. Antioxidant defences include the enzyme system and low molecular weight antioxidants. Metal-binding proteins, such as ferritin, ceruloplasmin and metallothioneins, have special functions in the detoxification of toxic metals and also play a role in the metabolism and homeostasis of essential metals. Recent studies of metallothioneins as biomarkers indicate that quantitative analysis of mRNA expression of metallothionein genes can be appropriate in cases with elevated levels of metals and no evidence of oxidative damage in fish tissue. Components of the antioxidant defence are used as biochemical markers of oxidative stress. These markers may be manifested differently in the field than in results found in laboratory studies. A complex approach should be taken in field studies of metal contamination of the aquatic environment. Keywords: ROS; metallothioneins; glutathion; superoxide dismutase; antioxidant defenceList of abbreviations ALA-D = aminolevulinic acid dehydratase; BNF = β-naphthoflavone; CAT = catalase; GPx = glutathione peroxidise; GR = glutathione reductase; GSH = glutathione; GSSG = glutathione disulphide; GST = glutathione S-transferase; LPO = lipid peroxidation; MDA = malondialdehyde; MTs = metallothioneins; NADPH = nicotinamidadeninedinucleotide phosphate (reduced); ROS = reactive oxygen species; SOD = superoxide dismutase

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“…These free radicals can evoke extensive tissue damage, reacting with macromolecules, such as membrane lipids, proteins, and nucleic acids (Emerit et al, 2001). Previously, enhanced lipid peroxidation and impairment in antioxidant defence mechanisms have been demonstrated in patients with lung and breast cancers (Kumaraguruparan et al, 2002;Aymelek et al, 2006) Nitric oxide (NO), which is synthesized by nitric oxide syntheses, is a poly functional signalling molecule controlling processes of vasodilatation, platelet aggregation, immunocytotoxicity, and carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

Gupta¹,

Patel²,

Kumari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this study was to determine changes in the levels of malondialdehyde (MDA), nitric oxide (NO), total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in serum samples of breast cancer patients (n=30) and healthy subjects (n=100). MDA and NO levels were found to be increased in breast cancer patients compared to the healthy subject group (p<0.05). Total cholesterol and triglycerides were elevated; and HDLcholesterol level was found to be decreased in the cancer patients as compared to the healthy subjects (p<0.05). Compared to the healthy group, both serum TAC levels (p<0.001) and activity of SOD and GSH-Px (p=0.05) were found to be decreased in the breast cancer patients as compared to the healthy controls. Considering the data presented in this study, we suggest that free radicals induce lipid eroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxidants in breast cancer.

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Iron metabolism, free radicals, and oxidative injury

Cited by 403 publications

References 37 publications

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Metals as a cause of oxidative stress in fish: a review

Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

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