Iron Metabolism in Hodgkin's Disease

Beamish, M. R.; Jones, Patricia A.; Trevett, D; Evans, I.H.; Jacobs, A.

doi:10.1038/bjc.1972.61

Cited by 34 publications

(9 citation statements)

References 12 publications

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“…Serum iron levels gradually increase towards its normal value as the clinical state improves. Similarly, in a group of patients with Hodgkin's disease, the fall of serum iron levels correlates with the severity and extent of disease ranging from mean values of 16.4, 11.4, 8.6, and 6.9 uM for stages 1, 2, 3, and 4 respectively [32]. A consistent finding in patients with malignant neoplasms is that hypoferremia increases as their clinical condition deteriorates and subsides during periods of remission [33].…”

Section: The Hypoferremic Responsementioning

confidence: 84%

Iron metabolism during infection and neoplasia

Letendre

1987

Cancer Metast Rev

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Invasion of the vertebrate host by microorganisms or neoplastic cells triggers a variety of metabolic responses. One of them, the hypoferremic response, is the decrease in serum iron levels. This hypoferremia is observed not only during infections of various etiologies and neoplasia but also during trauma, myocardial infarction, surgery, and inflammation. The hypoferremic response thus appears to be a consistent and predictable biochemical response to pathogenesis. Hypoferremia has been shown to be of great protective value to the host against infection and neoplasia. Suppression of the iron-withholding ability of the host by excess iron is associated with a greater incidence and severity of infection and neoplasia. The potential therapeutic applications of the hypoferremic response are discussed.

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Section: The Hypoferremic Responsementioning

confidence: 84%

Iron metabolism during infection and neoplasia

Letendre

1987

Cancer Metast Rev

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“…A direct correlation has been shown between the extent of disease and decreases in the saturation of transferrin in patients with Hodgkin's disease [167]. Although the uptake of nutrients may vary between normal and malignant cells an increased storage of iron has not generally been demonstrated: in fact, the iron content of certain tumours (e.g.…”

Section: Ironmentioning

confidence: 99%

Malignant disease: nutritional implications of disease and treatment

Holmes

Dickerson

1987

Cancer Metast Rev

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Protein-energy malnutrition (PEM) is common in cancer patients and may develop into the syndrome known as 'cancer cachexia'. This is characterised by complex disturbances in carbohydrate, lipid, protein, and electrolyte metabolism. The aetiology is equally complex, with host and therapeutic factors contributing to the reduced food intake and effects on host tissues. Anorexia is of prime importance, differing in its cause from one patient to another and often presenting a barrier to successful nutritional support. Further research is necessary to elucidate the interaction of central and peripheral factors that may be involved in the aetiology of anorexia. Because of the interplay of biochemical, physiological, and psychological consequences of cancer, the nutritional support of the patient presents a considerable challenge to the caring professions.

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“…De Sousa et al (1977 have reported poor proliferative responses to phytohaemaglutinin (PHA) of peripheral blood lymphocytes from patients with HD when compared with normal controls, corrected by splenectomy. This data coupled with observations of increased T-cell percentages in the spleens from patients with HD (Kaur et al, 1974;Payne et al, 1976;Gupta, 1980) led De Sousa et al (1977 to postulate that depressed cell immunity in the blood is a consequence of the sequestration of a particular T-cell subset in the spleen and further to suggest that this may be associated with the presence of iron binding proteins (IBP) in the cells of the reticuloendothelial system (De Sousa et al, 1978 Anomalies of iron handling by the phagocytic system in HD were first described by Beamish et al (1972). De Sousa et al (1977 examined iron deposition and the distribution of IBP in five spleens involved with the disease and one nonHodgkin's lymphoma control.…”

mentioning

confidence: 99%

“…Anomalies of iron handling by the phagocytic system in HD were first described by Beamish et al (1972). De Sousa et al (1977) examined iron deposition and the distribution of IBP in five spleens involved with the disease and one nonHodgkin's lymphoma control.…”

mentioning

confidence: 99%

The distribution of iron and iron binding proteins in spleen with reference to Hodgkin's disease

Britten¹,

Jones²,

Sousa³

et al. 1986

Br J Cancer

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Summary The distribution of iron and iron binding proteins (IBP) Hodgkin's disease (HD) is a progressive disorder of' the lymphoid system often accompanied by a deficiency in cell mediated immunity (Hansen & Good, 1974;Kaplan, 1976). The depression of cell mediated immunity in HD has been related to increased activity of suppressor cells (Twomey et al., 1980;Hillinger & Herzig, 1978;Goodwin et al., 1977; Sibbett et al., 1978), the presence of circulating inhibitory factors (Siegal, 1976; Fuks et al., 1976;Moroz et al., 1977), and, in advanced disease, decreased numbers of T-cells, (Aiuti et al., 1973;Bukowski et al., 1976). De Sousa et al. (1977 have reported poor proliferative responses to phytohaemaglutinin (PHA) of peripheral blood lymphocytes from patients with HD when compared with normal controls, corrected by splenectomy. This data coupled with observations of increased T-cell percentages in the spleens from patients with HD (Kaur et al., 1974;Payne et al., 1976;Gupta, 1980) led De Sousa et al. (1977 to postulate that depressed cell immunity in the blood is a consequence of the sequestration of a particular T-cell subset in the spleen and further to suggest that this may be associated with the presence of iron binding proteins (IBP) in the cells of the reticuloendothelial system (De Sousa et al., 1978 Anomalies of iron handling by the phagocytic system in HD were first described by Beamish et al. (1972). De Sousa et al. (1977 examined iron deposition and the distribution of IBP in five spleens involved with the disease and one nonHodgkin's lymphoma control. IBP were identified by immunofluorescent staining of frozen sections and iron by Perls Prussian blue technique. These results claimed a relationship between the distribution in the spleen of iron and IBP and involvement with HD. Smithyman et al. (1979) confirmed that elevated levels of ferritin were found in frozen sections of HD spleens, but again the study was small and the frozen section technique employed gave poor morphological detail. These reports suggest a specific relationship between IBP and, or, iron and the development of a cellular defect in HD. We were doubtful that this was so and this scepticism prompted us to study the distribution of iron and IBP not only in HD but also in other disorders including non-Hodgkin's lymphomas, thalassaemia and carcinoma where the haematological changes associated with HD may not occur.We present the results of a study of splenic tissue from 63 cases of lymphoma, 49 of which were from patients with HD. Various non-lymphomatous control spleens were included in the study incorporating spleens from patients with thalassaemia, a disease with a known abnormality in iron metabolism.

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Iron Metabolism in Hodgkin's Disease

Cited by 34 publications

References 12 publications

Iron metabolism during infection and neoplasia

Iron metabolism during infection and neoplasia

Malignant disease: nutritional implications of disease and treatment

The distribution of iron and iron binding proteins in spleen with reference to Hodgkin's disease

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