Iron/N-doped graphene nano-structured catalysts for general cyclopropanation of olefins

Sarkar, Amit; Formenti, Dario; Ferretti, Francesco; Kreyenschulte, Carsten; Bartling, Stephan; Junge, Kathrin; Beller, Matthias; Ragaini, Fabio

doi:10.1039/d0sc01650k

Cited by 15 publications

(3 citation statements)

References 45 publications

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“…Additionally, as shown in Figure S4 (Supporting Information), the NO 3 − peaks of MgAl‐NO 3 LDHs at ≈407 eV disappeared and a signal appears at 399 eV after MO loading, which corresponds to the N1s peak from the organic matrix of MO. [ 51 ]…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, as shown in Figure S4 (Supporting Information), the NO 3 − peaks of MgAl-NO 3 LDHs at ≈407 eV disappeared and a signal appears at 399 eV after MO loading, which corresponds to the N1s peak from the organic matrix of MO. [51] experienced more severe sudden release and reached a high release level during the first release stage. Also for the smaller LDH, the 1 st stage is followed by a second sustained release stage, which is in general also faster than that for the larger LDHs, the equilibrium release displays the maximum release that amounts to 21.97, 25.51, and 27.43 mg L −1 for MgAl-NO 3 S-LDH-MO in PBS of pH 7.4, 6.5, and 5.2, respectively.…”

Section: Ldhs Characteristics After Mo Loadingmentioning

confidence: 99%

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pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity

Warszawik

Rijn

2023

Adv Materials Inter

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The loading capacity and strategy of layered double hydroxides (LDHs) determine their suitability for drug delivery applications. In this study, two sizes of MgAl‐CO3 LDHs are converted into MgAl‐NO3 LDHs and MgAl‐Cl LDHs by an acid‐salt method. The influence of the size and type of interlayer anions of LDHs on their loading capacity are studied and compared. Here, Methylene Orange (MO) served as the anionic structure to determine the loading capacity. Due to the strongest anion‐exchange capacity of NO3− and larger interlayer distance of MgAl‐NO3 LDHs, they have impressive high loading capacities, which make these useful as absorbents or drug carriers. Additionally, the pH‐dependent release behaviors of MO‐loaded MgAl‐NO3 LDHs are investigated, which dictates both the release profile and maximum release. Above all, based on the study, it is found that the release of LDHs with agents loaded under mildly acidic environments is not based on its partial dissolution, which is commonly indicated. This study provides a better understanding of the loading and release process of LDHs, which allows for better incorporation of LDHs in biomedical‐related applications.

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Section: Resultsmentioning

confidence: 99%

Section: Ldhs Characteristics After Mo Loadingmentioning

confidence: 99%

pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity

Warszawik

Rijn

2023

Adv Materials Inter

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“…Over 100 approved and investigational drugs contain at least one quaternary center in their cyclopropane units, since it provides an elegant platform for pharmaceuticals and bioactive molecules to escape from flatland, which enables more specific interactions with biological targets. , Interestingly, recent research disclosed that a more potential aggrecanase-2 inhibitor with better selectivity and excellent pharmacokinetic profiles was obtained with a cyclopropane bearing two quaternary centers in comparison to one bearing one quaternary center (Figure ). , Therefore, the pharmaceutical significance and the structural intricacies of cyclopropane-containing molecules have inspired synthetic chemists to develop more efficient and sustainable strategies to construct highly congested cyclopropanes. − …”

Section: Introductionmentioning

confidence: 99%

Visible-Light-Mediated Energy Transfer Enables Cyclopropanes Bearing Contiguous All-Carbon Quaternary Centers

Xia

Wang

et al. 2023

ACS Catal.

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Cyclopropanes bearing contiguous all-carbon quaternary centers continue to attract attention due to their bioactivities. However, methods to obtain cyclopropanes with contiguous all-carbon quaternary centers remain largely unexplored due to the high steric hindrance of these compounds. Herein, we report a visible-light-mediated energy-transfer (EnT) strategy to realize in situ donor/donor carbenes from readily available N-tosylhydrazones, facilitating the synthesis of highly congested EWG-free cyclopropanes. Through this approach, cyclopropanes are rapidly installed into complex bioactive molecules, fluorescent molecules, and other useful building blocks that are challenging to synthesize. Detailed mechanistic reactions and DFT studies clearly demonstrated the role of the photosensitizer, the formation of donor/donor carbenes, and the necessity of light and a base in the system.

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Selective Cyclopropanation/Aziridination of Olefins Catalyzed by Bis(pyrazolyl)borate Cu(I) Complexes

et al. 2022

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Iron/N-doped graphene nano-structured catalysts for general cyclopropanation of olefins

Abstract: An Fe-based heterogeneous catalyst allows for the synthesis of cyclopropanes via a carbene transfer reaction, a transformation usually belonging to the homogeneous domain.

Cited by 15 publications

References 45 publications

pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity

pH‐Triggered Release and Degradation Mechanism of Layered Double Hydroxides with High Loading Capacity

Visible-Light-Mediated Energy Transfer Enables Cyclopropanes Bearing Contiguous All-Carbon Quaternary Centers

Selective Cyclopropanation/Aziridination of Olefins Catalyzed by Bis(pyrazolyl)borate Cu(I) Complexes

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