Iron overload in the HCT patient: a review

Tenneti, Pavan; Chojecki, Aleksander L.; Knovich, Mary Ann

doi:10.1038/s41409-021-01244-7

Cited by 13 publications

(8 citation statements)

References 63 publications

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“…[3]. In studying the biological behavior of metal ions, researchers have found that abnormal distribution of metal ions affect the various physiological function of cells, causing adverse effects and even death [4][5][6]. These findings suggest that metal ions have specific mechanisms for inducing cell death, which makes related strategies have been soon studied in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

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Due to the urgent demand for more anti-cancer methods, the new applications of metal ions in cancer have attracted increasing attention. Especially the three kinds of the new mode of cell death, including ferroptosis, calcicoptosis, and cuproptosis, are of great concern. Meanwhile, many metal ions have been found to induce cell death through different approaches, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, and generating the prooxidant effect. Therefore, varieties of new strategies based on the above approaches have been studied and applied for anti-cancer applications. Moreover, many contrast agents based on metal ions have gradually become the core components of the bioimaging technologies, such as MRI, CT, and fluorescence imaging, which exhibit guiding significance for cancer diagnosis. Besides, the new nano-theranostic platforms based on metal ions have experimentally shown efficient response to endogenous and exogenous stimuli, which realizes simultaneous cancer therapy and diagnosis through a more controlled nano-system. However, most metal-based agents have still been in the early stages, and controlled clinical trials are necessary to confirm or not the current expectations. This article will focus on these new explorations based on metal ions, hoping to provide some theoretical support for more anti-cancer ideas.

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Section: Introductionmentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

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“…The provision of copper, iodine, selenium, calcium, and phosphate was below RI (Figure 2 A, Table 1 (Supplemental Digital Content, http://links.lww.com/MPG/C912 ), Table 2 (Supplemental Digital Content, http://links.lww.com/MPG/C912 ). Iron was below RI, but this was considered adequate due to the risk of iron overload ( 37 ). Vitamin E was also considered adequate even below RI due to extra content in the lipid emulsions of PN solutions ( 35 ).…”

Section: Resultsmentioning

confidence: 99%

“…PN was supplemented with parenteral multivitamins (Vitalipid Infant and Soluvit, Fresenius Kabi) and trace elements (Peditrace, Fresenius Kabi) products ( 35 , 36 ). Peditrace was chosen to limit iron provision since HSCT patients are at risk of iron overload ( 37 ). Individual tailored PN solutions were used if metabolic complications ( 38 ).…”

Section: Methodsmentioning

confidence: 99%

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children

Kvammen

Thomassen

Buechner

et al. 2022

J. pediatr. gastroenterol. nutr.

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Objectives: This study aimed to describe the impact of allogeneic/haploidentical hematopoietic stem cell transplantation on nutritional status and intake in a group of children aged 2 to 18 years. Methods: In an observational study, data were collected prospectively. Patients were prescribed individual nutritional support by hospital routines. Anthropometrics were measured pre-transplant at hospital admission and weekly from the day of transplant (day 0) until day +28. z scores for weight, height, and BMI were calculated using Norwegian growth references to assess nutritional status. Pre-transplant diet was assessed on the day of hospitalization. Nutrient provision from enteral nutrition (EN = oral and tube) and parenteral nutrition (PN) was assessed by daily records from day +1 until day +28, or previous discharge, and compared with recommendations (RI) from the Nordic Nutrition Recommendations and ESPGHAN guidelines. Total energy intake was presented as the percentage (%) of basal metabolic rate (BMR) calculated by the Schofield equation. Macro-and micronutrient provisions were presented as medians (interquartile range) and the % of RI. Results: Twenty-eight patients, mean age 10.3 years (range 3.5-16.6), were included. Two-thirds (n = 18) had malignant diseases. At admission, mean weight Z-score was −0.3, height z scores −0.7, and BMI Z-score 0.1. Eighteen percent (n = 5) were stunted and 25% (n = 7) had overweight. At admission, 25% (n = 7) had established tube feeding, and 7% (n = 2) also had PN. No significant changes in weight z scores were detected during the studied weeks (P = 0.454). The median daily energy provision was 115% (110-123) of BMR and proteins 1.5 (1.3-1.8) g/kg. EN was provided during a median of 93% of the studied days and provided 21% of the energy. PN was given on a median of 96% of the studied days and provided 79% of energy. RI for vitamins, magnesium, and zinc was met. Provision of copper, iodine, selenium, calcium, and phosphate was below RI. Conclusions: Combined EN and PN providing 115% of BMR and 1.5 g/kg protein ensured stable weight by day +28 and covered RI, except for trace elements and minerals.

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“…16,61 The rationale for excluding iron is based on the potential iron overload from frequent blood transfusions. 16,62…”

Section: Variables That Impact Vitamin and Mineral Requirementsmentioning

confidence: 99%

Nutrition management of pediatric patients undergoing hematopoietic stem cell transplantation: Guidelines, gaps, and research

et al. 2023

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Medical nutrition therapy (MNT) is a key component of supportive care for children undergoing hematopoietic stem cell transplantation. During the transplant process, several complications and side effects may be encountered that require alteration of the nutrition support, interventions, and monitoring provided. The focus of this review is to discuss current guidelines and research for the provision of MNT to these patients, along with recommendations on how to bridge the gap in MNT knowledge.

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Iron overload in the HCT patient: a review

Cited by 13 publications

References 63 publications

New anti-cancer explorations based on metal ions

New anti-cancer explorations based on metal ions

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Nutritional Status and Intake in Children

Nutrition management of pediatric patients undergoing hematopoietic stem cell transplantation: Guidelines, gaps, and research

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