Iron oxide/bismuth oxide nanocomposites coated by graphene quantum dots: “Three-in-one” theranostic agents for simultaneous CT/MR imaging-guided in vitro photothermal therapy

Badrigilan, Samireh; Shaabani, Behrouz; Gharehaghaji, Nahideh; Mesbahi, Asghar

doi:10.1016/j.pdpdt.2018.10.021

Cited by 48 publications

(26 citation statements)

References 42 publications

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“…According to the ASTM E2524-08 standard, red blood cell (RBC) damage from foreign agents introduced into the body are significant when the degree of hemolysis reaches 5%. The results reported for Bi-based NMs revealed excellent blood compatibility with a hemolysis effect lower than 2%, 1,2,4,6,34,35,46,47,54,58,66 even at a high concentration of 800 µg•mL−1. 3…”

Section: Hemolytic Effectmentioning

confidence: 84%

“…Based on published evidence, the cytotoxicity of Bi-based NPs (such as bismuth selenide (Bi 2 Se 3 ), bismuth sulfide (Bi 2 S 3 ), copper bismuth sulphide (Cu 3 BiS 3 ), and pure Bi NPs) is insignificant against various cell lines even at high concentrations. 3,5,6,18,[23][24][25][26][27][28][29][30][31][32][33][34][35] In the case of Bi 2 S 3 , Liu et al 36 have evaluated the cytotoxicity of Bi 2 S 3 NPs in a panel of different cell lines, including lung adenocarcinoma A549 cells, human embryonic kidney 293 cells (HEK293), umbilical vein endothelial cells (HUVEC), and hepatocarcinoma (HepG2) cells. They found that Bi NPs induced minimal toxicity in HepG2 and HUVEC cells, representing negligible cytotoxicity on the human liver and blood vessels.…”

Section: Cell Viabilitymentioning

confidence: 99%

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A Review on the Biodistribution, Pharmacokinetics and Toxicity of Bismuth-Based Nanomaterials

Badrigilan¹,

Heydarpanahi²,

Choupani³

et al. 2020

IJN

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Here, bismuth-based nanomaterials (Bi-based NMs) are introduced as promising theranostic agents to enhance image contrast as well as for the therapeutic gain for numerous diseases. However, understanding the interaction of such novel developed nanoparticles (NPs) within a biological environment is a requisite for the translation of any promising agent from the lab bench to the clinic. This interaction delineates the fate of NPs after circulation in the body. In an ideal setting, a nano-based therapeutic agent should be eliminated via the renal clearance pathway, meanwhile it should have specific targeting to a diseased organ to reach an effective dose and also to overcome off-targeting. Due to their clearance pathway, biodistribution patterns and pharmacokinetics (PK), Bi-based NMs have been found to play a determinative role to pass clinical approval and they have been investigated extensively in vivo to date. In this review, we expansively discuss the possible toxicity induced by Bi-based NMs on cells or organs, as well as biodistribution profiles, PK and the clearance pathways in animal models. A low cytotoxicity of Bi-based NMs has been found in vitro and in vivo, and along with their long-term biodistribution and proper renal clearance in animal models, the translation of Bi-based NMs to the clinic as a useful novel theranostic agent is promising to improve numerous medical applications.

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Section: Hemolytic Effectmentioning

confidence: 84%

Section: Cell Viabilitymentioning

confidence: 99%

A Review on the Biodistribution, Pharmacokinetics and Toxicity of Bismuth-Based Nanomaterials

Badrigilan¹,

Heydarpanahi²,

Choupani³

et al. 2020

IJN

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“…Therefore, taking into account that normal tissue temperature is around 37°C, the rGO-Fe 3 O 4 can reach 50°C, which is considered a cell-killing temperature. 55 Furthermore, images captured with the thermal camera demonstrated two important results. The first is that photothermal capacity is provided by the graphene solution alone and not by the container (Figure 4B and Supplementary Video S2).…”

Section: Photothermal Behavior Of Rgo-fe 3 Omentioning

confidence: 98%

Efficacy and Molecular Effects of a Reduced Graphene Oxide/Fe3O4 Nanocomposite in Photothermal Therapy Against Cancer

Barrera¹,

Groot²,

Vargas³

et al. 2020

IJN

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Purpose: Expanded research on the biomedical applications of graphene has shown promising results, although interactions between cells and graphene are still unclear. The current study aims to dissect the cellular and molecular effects of graphene nanocomposite in photothermal therapy against cancer, and to evaluate its efficacy. Methods: In this study, a reduced graphene oxide and iron oxide (rGO-Fe 3 O 4) nanocomposite was obtained by chemical synthesis. The nanocomposite was fully characterized by Raman spectroscopy, TEM, VSM and thermal profiling. Cell-nanocomposite interaction was evaluated by confocal microscopy and viability assays on cancer cell line HeLa. The efficacy of the thermal therapy and changes in gene expression of Bcl-2 and Hsp70 was assessed. Results: The resulting rGO-Fe 3 O 4 nanocomposite exhibited superparamagnetic properties and the capacity to increase the surrounding temperature by 18-20°C with respect to the initial temperature. The studies of cell-nanocomposite interaction showed that rGO-Fe 3 O 4 attaches to cell membrane but there is a range of concentration at which the nanomaterial preserves cell viability. Photothermal therapy reduced cell viability to 32.6% and 23.7% with 50 and 100 µg/mL of nanomaterial, respectively. The effect of treatment on the molecular mechanism of cell death demonstrated an overexpression of anti-apoptotic proteins Hsp70 and Bcl-2 as an initial response to the therapy and depending on the aggressiveness of the treatment. Conclusion: The results of this study contribute to understanding the interactions between cell and graphene and support its application in photothermal therapy against cancer due to its promising results.

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“…CT it is also used in the studies reviewed, this strategy is based on differential levels of X-ray attenuation by tissues within the body to produce three dimensional high-contrast anatomic images enabling delineation between various structures [ 44 , 45 ]. In a study of Bi et al, a GO/ZnFe 2 O 4 /UCNPs nanocomposite is presented, abbreviated as GZUC [ 44 ].…”

Section: Graphene-based Magnetic Nanoparticles For Theranosticsmentioning

confidence: 99%

Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

et al. 2021

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The combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platforms. This magnetic nanosystem combines the excellent magnetic performance of magnetic nanoparticles with the unique properties of graphene-based materials, such as large surface area for functionalization, high charge carrier mobility and high chemical and thermal stability. This hybrid nanosystems aims toward a synergistic theranostic effect. Here, we focus on the most recent developments in GbMNPs for theranostic applications. Particular attention is given to the synergistic effect of these composites, as well as to the limitations and possible future directions towards a potential clinical application.

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Iron oxide/bismuth oxide nanocomposites coated by graphene quantum dots: “Three-in-one” theranostic agents for simultaneous CT/MR imaging-guided in vitro photothermal therapy

Cited by 48 publications

References 42 publications

<p>A Review on the Biodistribution, Pharmacokinetics and Toxicity of Bismuth-Based Nanomaterials</p>

<p>A Review on the Biodistribution, Pharmacokinetics and Toxicity of Bismuth-Based Nanomaterials</p>

<p>Efficacy and Molecular Effects of a Reduced Graphene Oxide/Fe<sub>3</sub>O<sub>4</sub> Nanocomposite in Photothermal Therapy Against Cancer</p>

Graphene-Based Magnetic Nanoparticles for Theranostics: An Overview for Their Potential in Clinical Application

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