Iron oxide-loaded nanotheranostics: Major obstacles to in vivo studies and clinical translation

Schleich, Nathalie; Danhier, Fabienne; Préat, Véronique

doi:10.1016/j.jconrel.2014.11.024

Cited by 102 publications

(46 citation statements)

References 122 publications

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“…However, none of the reported molecular MRI is currently used for routine clinical diagnostic evaluation, nor are any in clinical development. This raises questions as to whether SPIO-enhanced molecular MRI is sensitive and specific enough for use in clinical practice (3)(4)(5)(6). In the review article on Iron oxide-loaded nanotheranostics, Schleich et al (6) asked, why do so many papers describe nanomedicines while only a few nanomedicines are commercialized?…”

Section: A B C D E C B Amentioning

confidence: 99%

“…This raises questions as to whether SPIO-enhanced molecular MRI is sensitive and specific enough for use in clinical practice (3)(4)(5)(6). In the review article on Iron oxide-loaded nanotheranostics, Schleich et al (6) asked, why do so many papers describe nanomedicines while only a few nanomedicines are commercialized? Dassler and colleagues at the CT and MR Contrast Media Research division of Bayer Pharma AG (Berlin, Germany) investigated the minimum requirements for obtaining sensitive molecular MRI for use in tumor evaluations under optimal conditions (7).…”

Section: A B C D E C B Amentioning

confidence: 99%

“…Due to this reason and other obstacles discussed and published (3)(4)(5)(6)(8)(9)(10)(11)(12), this review avoids discuss 'molecular MRI' of SPIO using such approaches for tumor specific imaging.…”

Section: A B C D E C B Amentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Wáng

Idée

2017

Quant. Imaging Med. Surg.

199

116

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Section: A B C D E C B Amentioning

confidence: 99%

Section: A B C D E C B Amentioning

confidence: 99%

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A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Wáng

Idée

2017

Quant. Imaging Med. Surg.

199

116

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“…Thanks to their magnetic properties, magnetite nanoparticles find applications in several different areas such as targeted drug delivery [27], cancer diagnosis and treatment (hyperthermia) [28,29], as contrasting agents in magnetic resonance imaging (MRI) [30], for detoxification of biological fluids (e.g., blood) [31], and in cell separation [32]. Magnetic composites can be conveniently prepared by adding different adsorbents to the mixture of iron salts before coprecipitation.…”

Section: Introductionmentioning

confidence: 99%

A Proof-of-Concept Portable Water Purification Device Obtained from PET Bottles and a Magnetite-Carbon Nanocomposite

Gaita¹,

Evangelisti

Panzarasa

2018

Recycling

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Widespread access to potable water is still far from being granted to populations of developing countries, especially in rural zones. For this reason, the development of easy-to-make, easy-to-use water purification devices is a topic of great social and economic importance. Poly(ethylene terephthalate) (PET) bottles are available worldwide, even in the remotest and poorest countries, as testified by the increasingly common practice of re-using bottles for solar water disinfection (SODIS). Here, we demonstrate how PET bottles could be re-used as a proof-of-concept water purification system. In this way, virtually the same bottle could be used first for SODIS and then for removing chemical contaminants. In the proposed approach, the bottles are treated with ethylenediamine to introduce amine groups, which are subsequently protonated with dilute acid. These functional groups allow the stable adsorption of a magnetite-activated carbon nanocomposite, which is prepared by a simple coprecipitation protocol. The efficiency of the nanocomposite and of the resulting prototype to remove model inorganic and organic pollutants (hexavalent chromium, industrial dyes) from water has been demonstrated. The proposed purification device is easy, cheap, and effective, all factors which could promote its use in developing and rural countries.

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“…Common functionalization strategies include covalent bonding or grafting of ligands to the IONs' coating. Further approaches include the encapsulation of bioactive molecules and IONs into vehicles such as liposomes, micelles, or polymer nanoparticles, 54 and the immobilization of IONs and active ligands onto carbon nanomaterial. 55 However, when delivery of ION-bound therapeutics is considered, the challenging issue of unwanted/wanted release kinetics in response to internal and/or external (remote) stimuli comes into focus.…”

mentioning

confidence: 99%

Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?

Bietenbeck¹,

Florian²,

Faber³

et al. 2016

IJN

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Magnetic resonance imaging (MRI) allows for an accurate assessment of both functional and structural cardiac parameters, and thereby appropriate diagnosis and validation of cardiovascular diseases. The diagnostic yield of cardiovascular MRI examinations is often increased by the use of contrast agents that are almost exclusively based on gadolinium compounds. Another clinically approved contrast medium is composed of superparamagnetic iron oxide nanoparticles (IONs). These particles may expand the field of contrast-enhanced cardiovascular MRI as recently shown in clinical studies focusing on acute myocardial infarction (AMI) and atherosclerosis. Furthermore, IONs open up new research opportunities such as remote magnetic drug targeting (MDT). The approach of MDT relies on the coupling of bioactive molecules and magnetic nanoparticles to form an injectable complex. This complex, in turn, can be attracted to and retained at a desired target inside the body with the help of applied magnetic fields. In comparison to common systemic drug applications, MDT techniques promise both higher concentrations at the target site and lower concentrations elsewhere in the body. Moreover, concurrent or subsequent MRI can be used for noninvasive monitoring of drug distribution and successful delivery to the desired organ in vivo. This review does not only illustrate the basic conceptual and biophysical principles of IONs, but also focuses on new research activities and achievements in the cardiovascular field, mainly in the management of AMI. Based on the presentation of successful MDT applications in preclinical models of AMI, novel approaches and the translational potential of MDT are discussed.

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Iron oxide-loaded nanotheranostics: Major obstacles to in vivo studies and clinical translation

Cited by 102 publications

References 122 publications

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

A Proof-of-Concept Portable Water Purification Device Obtained from PET Bottles and a Magnetite-Carbon Nanocomposite

Remote magnetic targeting of iron oxide nanoparticles for cardiovascular diagnosis and therapeutic drug delivery: where are we now?

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