Iron status in chronic kidney disease patients

Deori, Rumi; Bhuyan, Bedanta

doi:10.18203/2320-6012.ijrms20162251

Cited by 9 publications

(11 citation statements)

References 24 publications

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“…19 The findings in this study is at variance with results of study done by Deori et al with reports of lower mean serum iron among the subjects than controls. 20 Here they believed"the lower mean value of serum iron in the latter study compared with this present study may be due to the fact that patients with CKD on haematinics were excluded in their study". The mean value of TIBC was statistically significantly higher in patients with CKD compared with control participants, which is similar to previous study done by Deori at al.…”

Section: Discussioncontrasting

confidence: 49%

“…6,23 However Deori et al reported a statistically significant lower value of TSAT in patients with CKD. 20 The difference in this present study compared to the latter study may be that anaemic patients with CKD in this study were on ESAs and iron supplement as part of their treatment protocol as recommended by the Kidney Disease Outcomes Initiative guidelines. 12 The guidelines recommend all anaemic adult patient with CKD on ESA be placed on iron supplementation.…”

Section: Discussionmentioning

confidence: 73%

“…12 The guidelines recommend all anaemic adult patient with CKD on ESA be placed on iron supplementation. Patients on haematinics were excluded from the study done by Deori et al 20 The major causes of CKD in this study were hypertension, diabetes mellitus, and chronic glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

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Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

Sanni¹,

Olawumi²,

Durotoye³

et al. 2022

Afr H. Sci.

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Background: Functional iron deficiency has been found to be a common cause of poor response to erythropoiesis stimulating agents in anaemic patients with chronic kidney disease (CKD). Objectives: Assess the functional iron status of patients with chronic kidney disease. Methods: This was a hospital based cross sectional study. The study subjects were chronic kidney disease patients with age and sex matched healthy controls. Full blood count, serum ferritin, soluble transferring receptor, C-reactive protein, serum iron and total iron binding capacity were measured in the patients and healthy controls. Data was analyzed with statistical package for the social sciences software version 22.0. And the level of statistical significance was set at p. value < 0.05. Results: The mean ± SD of the age of patient with CKD was 55.0 + 15.4 years, while that of controls was 52.7 + 13.6 years. The mean serum ferritin, serum iron, TIBC and CRP were significantly higher in patients compared with controls (p<0.001, 0.023, <0.001 and 0.001) respectively. Functional iron deficiency was seen in 19.5% of patients with CKD. Conclusion: The predominant form of iron deficiency in our study was functional iron deficiency. Keywords: Chronic kidney disease; functional iron status; anaemia.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 73%

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Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

Sanni¹,

Olawumi²,

Durotoye³

et al. 2022

Afr H. Sci.

View full text Add to dashboard Cite

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“…The results of this study support the theory in the study entitled "Iron chronic disease kidney disease patients" that there was no significant relationship between serum creatinine and TIBC in chronic kidney patients. 17 This is probably because not all people with chronic kidney disease are caused by iron deficiency anemia. Iron deficiency anemia in patients with CKD is mainly caused by poor nutritional intake, impaired absorption, chronic bleeding, inflammation or infection, and increased iron requirements during correction of anemia with Erythropoietin Stimulating Agent (ESA) therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Iron deficiency may be absolute, often due to poor dietary intake or sometimes occult bleeding, or functional, when there is an imbalance between the iron requirements of the erythroid marrow and the actual iron supply. 17 According to previous research, uses descriptive research design, the sample used 92 people and processed using Pearson correlation statistical test and Kolmogorov-Smirnov categorical test. Evaluating TIBC values, where 80% of CKD patients experience decreased TIBC levels.…”

Section: Introductionmentioning

confidence: 99%

The correlation between creatinine serum with total iron binding capacity (TIBC) on patients with sufferers chronic renal disease in Gambiran regional public hospital Kediri city

Ulya

Kusdinar

Santoso

2019

Melysa

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Chronic kidney disease (CKD) is kidney damage that occurs for more than 3 months with a glomerular filtration rate of less than 60 ml/sec/ 1.73 m2. WHO estimates that in Indonesia, there will be an increase in PGK in 1995-2025 by 41.4%. Over the past 40 years, Creatinine serum has become the most common and cheap serum marker for kidney function. One of the most common complications in patients with PGK is anemia. Anemia in PGK can be caused by several factors such as EPO deficiency, iron deficiency, etc. One of the usual parameters checking is the iron status of TIBC. This study aims to determine the relationship of serum Creatinine level with TIBC in chronic kidney patients in Gambiran regional public hospital Kediri and sampling taken by quota sampling. The study used cross-sectional using Rank Spearman statistic test. This test is used for abnormally distributed data types. The measured variable was serum Creatinine level with TIBC. The results of this study indicate that the value of p = (0.000)> α = (0.05), so H1 rejected and H0 accepted, then there is no relationship between serum Creatinine levels with TIBC in patients with chronic kidney disease in Gambiran Hospital Kediri.

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The Divalent Elements Changes in Early Stages of Chronic Kidney Disease

Kung

Shih

Lee

et al. 2017

Biol Trace Elem Res

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As the glomerular filtration rate (GFR) decreases, it can cause imbalance in some divalent elements. These imbalances can cause increased oxidative stress in patients with renal impairment. The aim of present study was to investigate the changes of these divalent elements with CKD progression. One hundred and ninety-four patients with chronic kidney diseases (CKD) were divided into five stages, stage 1, 2, 3a, 3b, 4, and were recruited into this study. The divalent elements, calcium, magnesium, phosphorus, as well as iron, zinc, and copper were determined in clinical chemistry analyzer. Higher CKD stages were found to be associated with increased levels of phosphorus and copper; P values were 0.002 and 0.004, respectively. Also, higher CKD stages were associated with decreased levels of zinc; P value was 0.002, after adjustment for age, gender, smoke, education, diabetes, hypertension, and BMI. Decreased levels of zinc and elevated levels of phosphorus and copper might increase the oxidative stress and complications in CKD patients. Future randomized studies are needed to show whether adjusting dietary intake of phosphorus, copper, and zinc might affect the progression of CKD.

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Iron status in chronic kidney disease patients

Cited by 9 publications

References 24 publications

Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria

The correlation between creatinine serum with total iron binding capacity (TIBC) on patients with sufferers chronic renal disease in Gambiran regional public hospital Kediri city

The Divalent Elements Changes in Early Stages of Chronic Kidney Disease

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