Iron store of pregnant women with hemoglobin SS and SC in Benin city

Ogbimi, Benedict N; Ehigiegba, AE

doi:10.4103/2278-960x.104295

Cited by 3 publications

(9 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One will therefore expect more studies looking at this potentially harmful complication of pregnancy in this subpopulation. Unfortunately, in the twenty-first century there is still no evidence based guideline outlining iron supplementation in this subgroup and only one study in 2012 has looked into iron stores in this subpopulation [32]. One could attempt to justify this with the notion of individuality of care (measuring iron status for each pregnant woman with sickle cell disease prior to making decisions on supplementing iron).…”

Section: Discussionmentioning

confidence: 99%

“…For articles without full texts that were potentially eligible for inclusion, the authors were contacted via email or other platforms such as ResearchGate. Constant weekly reminders were sent to these authors and the studies were automatically excluded if no response was received after 1 month [ 18 , 21 ].…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have been done to evaluate iron stores amongst PWSCD with varying outcomes [12][13][14][15][16]. While some studies report adequate stores, others have reported deficiency and even depletion [17,18]. Our study objectives were (1) to estimate the prevalence of iron deficiency anaemia among pregnant women with SCD.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Iron stores in pregnant women with sickle cell disease: a systematic review

Aroke

Kadia

Njim

2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Background Gradual improvements in the management of sickle cell disease (SCD), have led to an increase in the number of women with SCD who reach the age of procreation. However, evidence on the iron status of pregnant women with sickle cell disease (PWSCD) remains inconclusive. We conducted the first systematic review on the prevalence, determinants and maternal/foetal outcomes of iron deficiency anaemia among PWSCD. Methods We searched MEDLINE, EMBASE, Global Health, Africa Index Medicus, the Cochrane library databases and reference lists of retrieved publications for studies describing the iron status of PWSCD. The literature search was done over a period of 1 month, with no language or date restrictions applied. Data were extracted on a Microsoft excel sheet. Two authors assessed all included studies for methodological quality and risk of bias. Results A total of 710 reports were identified for title and article screening. Five retained studies were conducted before or during the 90s and included 67 participants. After quality assessment, the observational studies were designated to have a “fair” quality assessment while the randomised control trial had an “unclear” quality assessment. The prevalence of iron deficiency anaemia among PWSCD varied by study design and diagnostic method. The overall prevalence ranged from 6.67–83.33%. None of the studies provided evidence on factors associated with iron deficiency anaemia and the randomized trial reported no difference in outcomes between PWSCD who had iron supplementation and those who did not. Conclusion Evidence on factors associated with iron deficiency anaemia among PWSCD and maternal/foetal outcomes in PWSCD who have iron deficiency anaemia is poor. The studies included in this review suggests that iron deficiency anaemia may be highly prevalent in PWSCD but due to the very small sample sizes and varied study designs, this evidence is inconclusive. The review shows that there is a need for more studies with robust designs and adequate sample sizes to assess the disease burden of iron deficiency anaemia in PWSCD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Iron stores in pregnant women with sickle cell disease: a systematic review

Aroke

Kadia

Njim

2020

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…In people with SCA it is recommended to test body iron indices before the decision to supplement iron in pregnancy is made [ 17 , 18 ]. However, in sub-Saharan Africa with the greatest disease burden these machines are not readily available.…”

Section: Discussionmentioning

confidence: 99%

“…The differences in their outcomes were however thought to be related to their differences in methodology and study designs. Though the WHO currently has no recommendation for iron supplementation in PS, the traditional teaching has been that of no routine supplementation of iron in PS unless body iron indices confirm iron deficiency [ 17 , 18 ]. However, most of the patients with this disease live in low/middle income countries, where health facilities are not equipped with the necessary tools to measure body iron indices.…”

Section: Introductionmentioning

confidence: 99%

Iron supplementation in pregnant sicklers: an opinion

Aroke

Tchouakam

Kadia³

et al. 2018

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

Morbidity associated with iron deficiency anaemia in pregnancy is increased in the presence of sickle cell anaemia. Iron supplementation in pregnant sicklers in a bid to resolve iron deficiency anaemia is recommended only after laboratory confirmation of iron deficiency. However, the greatest burden of sickle cell disease is seen in low and middle income countries where equipment for measuring body iron indices are unavailable.Sickle cell anaemia is an inherited disorder of haemoglobin synthesis characterized by life-long severe haemolytic anaemia. People with sickle cell anaemia are at increased risk of iron overload from haemolysis and recurrent multiple transfusions. Iron overload a complication of sickle cell disease, which is more often in thalassemias, is typically given undue fear in sickle cell anaemia especially in patients with no recent transfusion history. About a third of the haemolysis in sickle cell anaemia is intravascular, and the resulting excess iron is lost in urine. This may lead to a negative iron balance and iron deficiency. There is little evidence of iron overload in pregnant sicklers, and iron deficiency may be more common than suspected. Even when iron overload does occur in a condition called siderosis, the deposited iron is irreversible and thus cannot be reused by the body in case of susceptibility to iron deficiency. More so, in pregnancy there is an increase in the body’s iron requirement by about 1000–1200 mg which is usually not met by dietary intake. Iron supplements could be given to pregnant sicklers, caution should however be taken in patients with history of recurrent transfusion.Anaemia is a common and feared complication in pregnancy. The co-existence of iron deficiency anaemia and sickle cell anaemia worsens prognosis of pregnancy. Iron overload a possible complication of sickle cell anaemia is related to multiple transfusions. The urinary losses from intravascular haemolysis and increased dietary requirement in pregnancy predispose even pregnant sicklers to iron deficiency anaemia. Iron supplements should thus conveniently be given to pregnant sicklers with no history of recurrent transfusions.

show abstract