Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation

Zhang, Joy Y; Wang, Jing; Lu, Qin; Tan, Mei; Ru, Wei; Lash, Gendie E.

doi:10.1042/bsr20202853

Cited by 6 publications

(8 citation statements)

References 32 publications

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“…To determine variables associated with cord blood hepcidin, the following variables for which a potential relationship has been shown in earlier studies [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ] were assessed: (1) ‘cord blood iron status’ (i.e., hemoglobin, ferritin, serum iron, transferrin and transferrin saturation); (2) ‘pre-gestational BMI’; (3) ‘pregnancy outcomes’ (i.e., onset of labor, mode of delivery); and 4) ‘neonatal outcomes’ (i.e., prematurity (born < 37 weeks), low birth weight (<2500 g), small for gestational age (SGA; <10th birth percentile) [ 29 ], and large for gestational age (LGA; > 90th birth percentile) [ 29 ]. Customized birth weight centiles were calculated, accounting for gestational age, fetal sex, parity, and single/multiple pregnancies.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, cord blood hepcidin values reflect fetal hepcidin status, at least at the time of delivery. Previous studies have found a correlation between cord blood hepcidin levels and cord blood iron status [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Likewise, cord blood hepcidin has been associated with maternal variables (e.g., body mass index or BMI) [ 13 , 21 ], pregnancy outcomes (e.g., gestational age at birth, mode of delivery) [ 14 , 15 , 16 ], and neonatal outcomes (e.g., birth weight) [ 17 ], regardless of some conflicting results across studies.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have found a correlation between cord blood hepcidin levels and cord blood iron status [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Likewise, cord blood hepcidin has been associated with maternal variables (e.g., body mass index or BMI) [ 13 , 21 ], pregnancy outcomes (e.g., gestational age at birth, mode of delivery) [ 14 , 15 , 16 ], and neonatal outcomes (e.g., birth weight) [ 17 ], regardless of some conflicting results across studies. Hence, insight into the relationship between cord blood hepcidin and maternal variables/pregnancy–neonatal outcomes could be instructive to contribute to identifying neonates at high(er) risk of low iron status.…”

Section: Introductionmentioning

confidence: 99%

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Hepcidin Status in Cord Blood: Observational Data from a Tertiary Institution in Belgium

et al. 2023

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The hormone hepcidin plays an important role in intestinal iron absorption and cellular release. Cord blood hepcidin values reflect fetal hepcidin status, at least at the time of delivery, but are not available for the Belgian population. Therefore, we aimed (1) to provide the first data on cord blood hepcidin levels in a Belgian cohort and (2) to determine variables associated with cord blood hepcidin concentrations. A cross-sectional, observational study was performed at the University Hospital Leuven, Belgium. Cord blood samples were analyzed using a combination of weak cation exchange chromatography and time-of-flight mass spectrometry. Descriptive statistics, Spearman correlation tests, and Mann–Whitney U tests were performed. In total, 61 nonhemolyzed cord blood samples were analyzed. The median hepcidin level was 17.6 μg/L (IQR: 18.1; min-max: 3.9–54.7). A moderate correlation was observed between cord blood hepcidin and cord blood ferritin (r = 0.493) and hemoglobin (r = −0.342). Cord blood hepcidin was also associated with mode of delivery (p = 0.01), with higher hepcidin levels for vaginal deliveries. Nonetheless, larger studies are needed to provide more evidence on the actual clinical value and benefit of cord blood hepcidin measurements.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hepcidin Status in Cord Blood: Observational Data from a Tertiary Institution in Belgium

et al. 2023

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“…Several risk factors for infection and poor outcome including impaired neurological development have been defined for infants born between late pre-term (≥34 weeks and <37 weeks of gestation) and early term (≥37 week to <39 weeks gestation) (95,96). Furthermore, gestational age (GA) correlates with neonatal plasma biomarkers such as hemoglobin and iron at birth (67)(68)(69)(70). We assessed whether plasma concentrations of ADAs may correlate with GA, although by definition, we did not include any infant below 36 weeks gestation.…”

Section: Discussionmentioning

confidence: 99%

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life

et al. 2021

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BackgroundHuman adenosine deaminases (ADAs) modulate the immune response: ADA1 via metabolizing adenosine, a purine metabolite that inhibits pro-inflammatory and Th1 cytokine production, and the multi-functional ADA2, by enhancing T-cell proliferation and monocyte differentiation. Newborns are relatively deficient in ADA1 resulting in elevated plasma adenosine concentrations and a Th2/anti-inflammatory bias compared to adults. Despite the growing recognition of the role of ADAs in immune regulation, little is known about the ontogeny of ADA concentrations.MethodsIn a subgroup of the EPIC002-study, clinical data and plasma samples were collected from 540 Gambian infants at four time-points: day of birth; first week of life; one month of age; and four months of age. Concentrations of total extracellular ADA, ADA1, and ADA2 were measured by chromogenic assay and evaluated in relation to clinical data. Plasma cytokines/chemokine were measured across the first week of life and correlated to ADA concentrations.ResultsADA2 demonstrated a steady rise across the first months of life, while ADA1 concentration significantly decreased 0.79-fold across the first week then increased 1.4-fold by four months of life. Males demonstrated significantly higher concentrations of ADA2 (1.1-fold) than females at four months; newborns with early-term (37 to <39 weeks) and late-term (≥41 weeks) gestational age demonstrated significantly higher ADA1 at birth (1.1-fold), and those born to mothers with advanced maternal age (≥35 years) had lower plasma concentrations of ADA2 at one month (0.93-fold). Plasma ADA1 concentrations were positively correlated with plasma CXCL8 during the first week of life, while ADA2 concentrations correlated positively with TNFα, IFNγ and CXCL10, and negatively with IL-6 and CXCL8.ConclusionsThe ratio of plasma ADA2/ADA1 concentration increased during the first week of life, after which both ADA1 and ADA2 increased across the first four months of life suggesting a gradual development of Th1/Th2 balanced immunity. Furthermore, ADA1 and ADA2 were positively correlated with cytokines/chemokines during the first week of life. Overall, ADA isoforms demonstrate robust ontogeny in newborns and infants but further mechanistic studies are needed to clarify their roles in early life immune development and the correlations with sex, gestational age, and maternal age that were observed.

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“…Interleukin 6 (IL-6), the primary hepcidin regulator, disturbs iron homeostasis and leads to the expression of vascular cell adhesion molecule (VCAM1) and intercellular adhesion molecules (ICAM-1), maintaining endothelium adhesive phenotype. 17,[23][24][25][26][27][28][29] Spontaneous abortion World Health Organization (WHO) defines SA as the termination or removal of a fetus of weight ≤ 500 grams before the 20 th week of gestation. 21,27 The incidence of spontaneous miscarriage is 10-30% worldwide of clinically diagnosed pregnancies, of which 80% are within 12 weeks of pregnancy.…”

Section: Ironmentioning

confidence: 99%

Micronutrients in Adverse Pregnancy Outcomes

et al. 2022

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About 10 to 20% of reported pregnancies have complications like spontaneous abortion (SA), preeclampsia (PE), preterm birth (PTB), and fetal growth restriction (FGR); 60% are attributed to maternal nutritional alterations. Multiple micronutrients (MMN) are supplemented in the antenatal period, but no proper validation/guidelines are available regarding dosing/time, the need for initiation, and the duration of supplementation. Studies have reported adverse pregnancy complications related to the overuse/unwanted use of multiple micronutrient supplementations during pregnancy. Identifying the exact population requiring supplementation is necessary to prevent its abuse. This article attempts to review the impacts of micronutrient deficiency/supplementation in cases of SA, FGR, and gestational diabetes mellitus (GDM), preterm delivery and PE. The study used a literature search using PubMed, Google Scholar, Mendeley, and Scopus Databases using search words pregnancy, spontaneous abortion, gestational diabetes mellitus (GDM), fetal growth restriction (FGR), preterm delivery, preeclampsia (PE) or “adverse pregnancy” associated with minerals, micronutrients, or supplementation. The review also considered in-house literature databases, a single-window search at Kasturba Medical College (KMC) Health sciences library, MAHE (Manipal Academy of Higher Education). The figures included in the study were created by Biorender.com. Micronutrients play multiple roles during pregnancy and fetoplacental growth stimulating growth hormone secretion, Lysyl oxidase (LOX), involved in the crosslinking between collagen and elastin in the amniotic membrane, downregulation of interleukin (IL)-1 alpha, IL-1 beta, IL-4, IL-6, Il-10, IL-12, tumor necrosis factor (TNF)-alpha and several chemokines involved in hypertension, immune-inflammatory pathways, attenuate insulin resistance a structural development of neurons and glia. Over-supplementation has led to complications such as spontaneous abortion and gestational diabetes mellitus. Since there is a lack of standardization concerning micronutrient supplementation during pregnancy, there is a need for systematic study related to the role of micronutrients during each trimester of pregnancy to optimize its supplementation and to prevent hazards associated with its abuse.

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Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation

Cited by 6 publications

References 32 publications

Hepcidin Status in Cord Blood: Observational Data from a Tertiary Institution in Belgium

Hepcidin Status in Cord Blood: Observational Data from a Tertiary Institution in Belgium

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life

Micronutrients in Adverse Pregnancy Outcomes

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