Iron Therapy in the Treatment of Anæmia in Pregnancy

Vogel, Lotte K.; Steingold, L.; Suchet, J.

doi:10.1016/s0140-6736(63)91989-5

Cited by 8 publications

(4 citation statements)

References 8 publications

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“…In 44 trials women received different types of iron (for example ferrous iron versus iron fumarate), or women received iron with or without other vitamins or supplements (Afifi 1978; Babior 1985; Balmelli 1974; Burslem 1968; Buss 1981; Carrasco 1962; Castren 1968; Chanarin 1968; Coelho 2000; Dawson 1987; Dijkhuizen 2004; Ekstrom 1996; Fletcher 1971; Giles 1971; Gringras 1982; Hartman-Craven 2009; Hosokawa 1989; Kaestel 2005; Kann 1988; Lira 1989; Ma 2008; Mbaye 2006; Metz 1965; Morrison 1977; Nogueira 2002; Ogunbode 1984; Ogunbode 1992; Osrin 2005; Payne 1968; Rae 1970; Ramakrishnan 2003; Rayado 1997; Rolschau 1979; Roth 1980; Rybo 1971; Saha 2007; Shatrugna 1999; Sjostedt 1977; Srisupandit 1983; Stone 1975; Trigg 1976; Weil 1977; Willoughby 1966; Willoughby 1968). In 34 trials both groups received iron and either different doses of iron were compared (Aaseth 2001; Ahn 2006; Brown 1972; Guldholt 1991; Horgan 1966; Madan 1999; Milman 2005; Nguyen 2008; Reddaiah 1989; Thane-Toe 1982; Thomsen 1993; Vogel 1963; Zhou 2009), or different types of regimen (for example daily versus weekly iron) (Bhatla 2009; Casanueva 2003a; Chew 1996a; Chew 1996b; Ekstrom 2002; Gomber 2002; Goonewardene 2001; Grover 1998; Liu 1996; Mukhopadhyay 2004; Mumtaz 2000; Pena-Rosas 2003; Pita Martin 1999; Quintero 2004; Ridwan 1996; …”

Section: Resultsmentioning

confidence: 99%

“…In 34 trials both groups received iron and either different doses of iron were compared (Aaseth 2001; Ahn 2006; Brown 1972; Guldholt 1991; Horgan 1966; Madan 1999; Milman 2005; Nguyen 2008; Reddaiah 1989; Thane-Toe 1982; Thomsen 1993; Vogel 1963; Zhou 2009), or different types of regimen (for example daily versus weekly iron) (Bhatla 2009; Casanueva 2003a; Chew 1996a; Chew 1996b; Ekstrom 2002; Gomber 2002; Goonewardene 2001; Grover 1998; Liu 1996; Mukhopadhyay 2004; Mumtaz 2000; Pena-Rosas 2003; Pita Martin 1999; Quintero 2004; Ridwan 1996; Robinson 1998; Winichagoon 2003; Yecta 2011; Young 2000; Yu 1998; Zamani 2008). (Daily versus intermittent oral iron regimens in pregnancy are examined in a related Cochrane review (Pena-Rosas 2012).…”

Section: Resultsmentioning

confidence: 99%

“…Both groups received iron. The type of comparison is not within the scope of this review Vogel 1963 191 consecutive pregnant when attending antenatal care clinics and at 32 weeks of gestation were divided in 2 groups by alternate allocation by clinic: group 1 received 140 mg of elemental iron daily (as ferrous gluconate) in 4 tablets; group 2 received 150 mg elemental iron daily (as ferrous glutamate) in 3 tablets. All women received iron in different dose and number of tablets.…”

Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

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Daily oral iron supplementation during pregnancy

Peña-Rosas

De-Regil

Dowswell

et al. 2012

Cochrane Database of Systematic Reviews

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

See 1 more Smart Citation

Daily oral iron supplementation during pregnancy

Peña-Rosas

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Dowswell

et al. 2012

Cochrane Database of Systematic Reviews

401

373

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“…Women received 100 mg of elemental iron (as ferrous sulphate) daily or no treatment from the third month of gestation until delivery. Follow-up was until 12 wks after delivery Vogel 1963 191 consecutive pregnant when attending antenatal care clinics and at 32 wks of gestation were divided in two groups by alternate allocation by clinic: group 1 received 140 mg of elemental iron daily (as ferrous gluconate) in four tablets; group 2 received 150 mg elemental iron daily (as ferrous glutamate) in 3 tablets. All women received iron in different dose and number of tablets.…”

Section: Discussionmentioning

confidence: 99%

Intermittent oral iron supplementation during pregnancy

Peña-Rosas

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Dowswell

et al. 2012

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Background Anaemia is a frequent condition during pregnancy, particularly among women from developing countries who have insufficient iron intake to meet increased iron needs of both the mother and the fetus. Traditionally, gestational anaemia has been prevented with the provision of daily iron supplements throughout pregnancy, but adherence to this regimen due to side effects, interrupted supply of the supplements, and concerns about safety among women with an adequate iron intake, have limited the use of this intervention. Intermittent (i.e. one, two or three times a week on non-consecutive days) supplementation with iron alone or in combination with folic acid or other vitamins and minerals has recently been proposed as an alternative to daily supplementation. Objectives To assess the benefits and harms of intermittent supplementation with iron alone or in combination with folic acid or other vitamins and minerals to pregnant women on neonatal and pregnancy outcomes. Search methods We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (23 March 2012). We also searched the WHO International Clinical Trials Registry Platform (ICTRP) for ongoing studies and contacted relevant organisations for the identification of ongoing and unpublished studies (23 March 2012). Selection criteria Randomised or quasi-randomised trials. Data collection and analysis We assessed the methodological quality of trials using standard Cochrane criteria. Two review authors independently assessed trial eligibility, extracted data and conducted checks for accuracy. Main results This review includes 21 trials from 13 different countries, but only 18 trials (with 4072 women) reported on our outcomes of interest and contributed data to the review. All of these studies compared daily versus intermittent iron supplementation. Three studies provided iron alone, 12 iron+folic acid and three more iron plus multiple vitamins and minerals. Their methodological quality was mixed and most had high levels of attrition. Overall, there was no clear evidence of differences between groups for infant primary outcomes: low birthweight (average risk ratio (RR) 0.96; 95% confidence interval (CI) 0.61 to 1.52, seven studies), infant birthweight (mean difference MD −8.62 g; 95% CI −52.76 g to 35.52 g, eight studies), premature birth (average RR 1.82; 95% CI 0.75 to 4.40, four studies). None of the studies reported neonatal deaths or congenital anomalies. For maternal outcomes, there was no clear evidence of differences between groups for anaemia at term (average RR 1.22; 95% CI 0.84 to 1.80, four studies) and women receiving intermittent supplementation had less side effects (average RR 0.56; 95% CI 0.37 to 0.84, 11 studies) than those receiving daily supplements. Women receiving intermittent supplements were also at lower risk of having high haemoglobin (Hb) concentrations (greater than 130 g/L) during the second or third trimester of pregnancy (average RR 0.48; 95% CI 0.35 to 0.67, 13 studies). There were no significant differenc...

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