Irradiation augmentation of genistein-induced apoptosis in androgen-independent DU-145 prostate cancer cells in vitro

Altaf, Rida; Kumi-Diaka, J.; Branly, Rolando

doi:10.15406/jcpcr.2018.09.00381

Cited by 1 publication

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“…It blocked the synthesis of 3βHSD, 17βHSD, StAR, SRB1, and CYP17A enzymes involved in the intracrine synthesis of AR while hindering cell growth, proliferation in LNCaP, and PC346C CaP cells through inducing apoptosis ( Batra et al., 2020 ). Genistein elevates the effect of a shallow dose of irradiation (20 mGy/h) in DU145 cells to induce apoptotic cell death more efficiently ( Altaf et al., 2019 ). A recent study with Genistein showed that it hindered the pathways involved in the transformation of a simple form of PCa to a highly lethal motility phenotype and long term use of soy product; Genistein can instigate compensatory changes in the response of biomarkers involved in cell motility (MEK4, MMP2) in human PCa cells ( Zhang, 2019 ).…”

Section: Importance Of Natural Products In Prostate Cancer Therapymentioning

confidence: 99%

Prostate cancer: Therapeutic prospect with herbal medicine

Ghosh

Hazra

Pal

et al. 2021

Current Research in Pharmacology and Drug Discovery

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Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. A geographic variation on the burden of the disease suggested that the environment, genetic makeup, lifestyle, and food habits modulate one's susceptibility to the disease. Although it has been generally thought to be an older age disease, and awareness and timely execution of screening programs have managed to contain the disease in the older population over the last decades, the incidence is still increasing in the population younger than 50. Existing treatment is efficient for PCa that is localized and responsive to androgen. However, the androgen resistant and metastatic PCa are challenging to treat. Conventional radiation and chemotherapies are associated with severe side effects in addition to being exorbitantly expensive. Many isolated phytochemicals and extracts of plants used in traditional medicine are known for their safety and diverse healing properties, including many with varying levels of anti-PCa activities. Many of the phytochemicals discussed here, as shown by many laboratories, inhibit tumor cell growth and proliferation by interfering with the components in the pathways responsible for the enhanced proliferation, metabolism, angiogenesis, invasion, and metastasis in the prostate cells while upregulating the mechanisms of cell death and cell cycle arrest. Notably, many of these agents simultaneously target multiple cellular pathways. We analyzed the available literature and provided an update on this issue in this review article.

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Section: Importance Of Natural Products In Prostate Cancer Therapymentioning

confidence: 99%