Irradiation of breast cancer cells enhances CXCL16 ligand expression and induces the migration of natural killer cells expressing the CXCR6 receptor

Yoon, Myung Ha; Pham, Tin Chanh; Phan, Minh‐Trang Thi; Shin, Dong Ju; Jang, Youn-Young; Park, Min‐Ho; Kim, Sang‐Ki; Kim, Seokho; Cho, Duck

doi:10.1016/j.jcyt.2016.08.006

Cited by 58 publications

(48 citation statements)

References 25 publications

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“…This increased expression of CXCL16 facilitates an enhanced migration NK cells (Figure 4) toward the tested tumor cells (101). …”

Section: Cytokines and Chemokinesmentioning

confidence: 95%

“…Expression of CXCL16, the only known ligand for chemokine receptor CXCR6—expressed on NK cells, is increased in various breast cancer (MCF7, SKBR3, and MDA-MB231, 4T1, 67NR, HTB-20), melanoma (B16/F10), fibrosarcoma (MC57), and colon carcinoma (MCA38) cell lines after γ-irradiation (2–20 Gy) (88, 90, 101). This increased expression of CXCL16 facilitates an enhanced migration NK cells (Figure 4) toward the tested tumor cells (101).…”

Section: Cytokines and Chemokinesmentioning

confidence: 99%

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Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities

Diegeler

Hellweg

2017

Front. Immunol.

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Ionizing radiation can affect the immune system in many ways. Depending on the situation, the whole body or parts of the body can be acutely or chronically exposed to different radiation qualities. In tumor radiotherapy, a fractionated exposure of the tumor (and surrounding tissues) is applied to kill the tumor cells. Currently, mostly photons, and also electrons, neutrons, protons, and heavier particles such as carbon ions, are used in radiotherapy. Tumor elimination can be supported by an effective immune response. In recent years, much progress has been achieved in the understanding of basic interactions between the irradiated tumor and the immune system. Here, direct and indirect effects of radiation on immune cells have to be considered. Lymphocytes for example are known to be highly radiosensitive. One important factor in indirect interactions is the radiation-induced bystander effect which can be initiated in unexposed cells by expression of cytokines of the irradiated cells and by direct exchange of molecules via gap junctions. In this review, we summarize the current knowledge about the indirect effects observed after exposure to different radiation qualities. The different immune cell populations important for the tumor immune response are natural killer cells, dendritic cells, and CD8+ cytotoxic T-cells. In vitro and in vivo studies have revealed the modulation of their functions due to ionizing radiation exposure of tumor cells. After radiation exposure, cytokines are produced by exposed tumor and immune cells and a modulated expression profile has also been observed in bystander immune cells. Release of damage-associated molecular patterns by irradiated tumor cells is another factor in immune activation. In conclusion, both immune-activating and -suppressing effects can occur. Enhancing or inhibiting these effects, respectively, could contribute to modified tumor cell killing after radiotherapy.

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“…This increased expression of CXCL16 facilitates an enhanced migration NK cells (Figure 4) toward the tested tumor cells (101). …”

Section: Cytokines and Chemokinesmentioning

confidence: 95%

Section: Cytokines and Chemokinesmentioning

confidence: 99%

Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities

Diegeler

Hellweg

2017

Front. Immunol.

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“…Intercellular adhesion molecule-1 (ICAM-1) surface expression was also induced upon irradiation to promote enhancing effects on NK cell cytotoxicity in human in vitro models [50]. Furthermore, chemokine (C-X-C motif) ligand 6 (CXCL6) was upregulated in a human in vitro model of irradiation, leading to enhanced NK cell migration [112]. Surface calreticulin expression, an endogenous danger signal expressed upon irradiation [21,22], was shown to enhance NK cell-mediated cytotoxicity [113].…”

Section: The Innate Immune Systemmentioning

confidence: 99%

Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy

Kabiljo

Harpain

Carotta

et al. 2019

Cancers

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Radiation-induced immunogenic cell death has been described to contribute to the efficacy of external beam radiotherapy in local treatment of solid tumors. It is well established that radiation therapy can induce immunogenic cell death in cancer cells under certain conditions. Initial clinical studies combining radiotherapy with immunotherapies suggest a synergistic potential of this approach. Improving our understanding of how radiation reconditions the tumor immune microenvironment should pave the way for designing rational and robust combinations with immunotherapeutic drugs that enhance both local and systemic anti-cancer immune effects. In this review, we summarize irradiation-induced types of immunogenic cell death and their effects on the tumor microenvironment. We discuss preclinical insights on mechanisms and benefits of combining radiotherapy with immunotherapy, focusing on immune checkpoint inhibitors. In addition, we elaborate how these observations were translated into clinical studies and which parameters may be optimized to achieve best results in future clinical trials.

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“…It mainly functions as a scavenger receptor for oxidized low‐density lipoprotein (oxLDL), and as an adhesion molecule for cells expressing CXCR6 . The soluble form of CXCL16 is produced by constitutive or inducible cleavage of the transmembrane form, and this is involved in inducing the homing process of several leukocytes, including monocytes, T‐lymphoid cells, and natural killer (NK) cells …”

Section: Introductionmentioning

confidence: 99%

“…8,9 The soluble form of CXCL16 is produced by constitutive or inducible cleavage of the transmembrane form, and this is involved in inducing the homing process of several leukocytes, including monocytes, T-lymphoid cells, and natural killer (NK) cells. 7,8,[10][11][12] The maternal-fetal interface expresses a variety of chemokines and their receptors, including CCL1, CCL3, CCL4, CCL9, CXCL6, and CXCL12, which form a complex network that precisely regulates the proliferation and differentiation of trophoblasts. [13][14][15] In addition, chemokines are involved in the recruitment and differentiation of immune cells, processes that are essential to maintain the special immune microenvironment at the maternal-fetal interface.…”

Section: Introductionmentioning

confidence: 99%

The role of CXC chemokine ligand 16 in physiological and pathological pregnancies

Shi

Yang

Fan

et al. 2020

American J Rep Immunol

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The survival and development of a semi‐allogeneic fetus during pregnancy require the involvement of a series of cytokines and immune cells. Chemokines are a type of special cytokine those were originally described as having a role in leukocyte trafficking. CXC chemokine ligand (CXCL) 16 is a member of the chemokine family, and CXC chemokine receptor (CXCR) 6 is its sole receptor. Emerging evidence has shown that CXCL16/CXCR6 is expressed at the maternal‐fetal interface, by cell types that include trophoblast cells, decidual stroma cells, and decidual immune cells (eg, monocytes, γδT cells, and natural killer T (NKT) cells). The regulation of expression of CXCL16 is quite complex, and this process involves a multitude of factors. CXCL16 exerts a critical role in the establishment of a successful pregnancy through a series of molecular interactions at the maternal‐fetal interface. However, an abnormal expression of CXCL16 is associated with certain pathological states associated with pregnancy, including recurrent miscarriage, pre‐eclampsia, and gestational diabetes mellitus (GDM). In the present review, the expression and pleiotropic roles of CXCL16 under conditions of physiological and pathological pregnancy are systematically discussed.

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Irradiation of breast cancer cells enhances CXCL16 ligand expression and induces the migration of natural killer cells expressing the CXCR6 receptor

Cited by 58 publications

References 25 publications

Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities

Intercellular Communication of Tumor Cells and Immune Cells after Exposure to Different Ionizing Radiation Qualities

Radiotherapy as a Backbone for Novel Concepts in Cancer Immunotherapy

The role of CXC chemokine ligand 16 in physiological and pathological pregnancies

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