Irradiation of Pediatric High-Grade Spinal Cord Tumors

Tendulkar, Rahul D.; Panandiker, Atmaram S. Pai; Wu, Shengjie; Kun, Larry E.; Broniscer, Alberto; Sanford, Robert A.; Merchant, Thomas E.

doi:10.1016/j.ijrobp.2009.09.071

Cited by 34 publications

(30 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Median survival for GBM was 7 months and for AA it was 12 months. This finding reflects what has been published in the literature about cranial and spinal high-grade gliomas: correlation between higher grade of tumor and mortality is also reported by other groups [6,9,10]. Merchant et al [11] report otherwise in one retrospective study of 11 pediatric HGSCA patients where no difference in survival was found between patients with grade III and IV tumors; however, multiple other reports corroborate a worse prognosis with grade IV tumors.…”

Section: Discussionsupporting

confidence: 85%

“…For instance, Wolff et al [6] noted lower tumor grade to be a statistically significant prognostic indicator of longer overall survival. Tendulkar et al [9 ]found that GBM had higher rates of local progression than AA. At the cellular level, differences in tumor biology have been described [12].…”

Section: Discussionmentioning

confidence: 99%

“…Other publications on this specific subtype of cancer are mostly case reports and retrospective series with smaller sample sizes [2,9,11,24,28]. A notable comparison is with Wolff et al [6], who used the HIT-GBM registry to report on 28 pediatric patients with HGSCA from a European population.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of Risk Factors and Survival in Pediatric High-Grade Spinal Cord Astrocytoma: A Population-Based Study

Lam¹,

Lin²,

Melkonian

2012

Pediatr Neurosurg

View full text Add to dashboard Cite

Background/Aims: Primary pediatric high-grade spinal cord astrocytomas are rare neoplasms with poor prognoses. Using the Surveillance, Epidemiology, and End Results (SEER) database, we analyzed prognostic factors and survival. Methods: Pediatric patients with histologically confirmed diagnoses of primary high-grade spinal cord astrocytoma (WHO grade III-IV) from 1973 to 2008 in the SEER database were studied. Univariate and multivariate Cox proportional hazards models were used to analyze the relationship between demographic, tumor grade, and treatment factors on survival. Results: Median survival in the 48 patient cohort was 10 months. Increasing age and higher tumor grade were found to be significantly associated with higher mortality. For children aged <7, 7-12, and 13-18 years, median survival was 22, 11, and 8 months, respectively. For children with anaplastic astrocytoma (WHO grade III), median survival was 12 months, compared with 7 months for those with glioblastoma multiforme (WHO grade IV). This study did not find a statistically significant relationship between sex, race, presence of radiation therapy or extent of surgical resection and mortality. Conclusion: Survival in primary pediatric high-grade spinal cord astrocytomas was positively associated with younger age and lower tumor grade. Survival was not associated with other demographic or treatment modality factors.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of Risk Factors and Survival in Pediatric High-Grade Spinal Cord Astrocytoma: A Population-Based Study

Lam¹,

Lin²,

Melkonian

2012

Pediatr Neurosurg

View full text Add to dashboard Cite

show abstract

“…It must be noted that in retrospective studies, there is some evidence of prolonged progression-free and overall survival, especially in high-grade IMSCTs and in ependymomas. 3,11,13,24 A series of publications have already reported good outcomes (using the mMS) and determined the safety and efficacy of the best possible microsurgical tumor removal with the aid of intraoperative neurophysiological monitoring. 1,2,[5][6][7][8]12,14,17,18,21,25 No significant overall impact on reported QOL can be measured using the PedsQL 4.0 when comparing children with IMSCT and a healthy collective.…”

Section: Discussionmentioning

confidence: 99%

Quality of life after surgical treatment of primary intramedullary spinal cord tumors in children

Schneider¹,

Hidalgo²,

Schmitt‐Mechelke

et al. 2014

PED

View full text Add to dashboard Cite

Object Presently, the best available treatment for intramedullary spinal cord tumors (IMSCTs) in children is microsurgery with the objective of maximal tumor removal and minimal neurological morbidity. The latter has become manageable with the development and standard use of intraoperative neurophysiological monitoring. Traditionally, the perioperative neurological evaluation is based on surgical or spinal cord injury scores focusing on sensorimotor function. Little is known about the quality of life after such operations; therefore, this study was designed to investigate the impact of surgery for IMSCTs on the quality of life in children. Methods Twelve consecutive pediatric patients treated for IMSCT were included in this retrospective fixed cohort study. A multidimensional questionnaire-based quality of life instrument, the Pediatric Quality of Life Questionnaire version 4 (PedsQL 4.0), was chosen to analyze follow-up data. This validated instrument particularly allows for a comparison between a patient cohort and a healthy pediatric sample population. Results Of 11 mailed questionnaires (1 patient had died of progressive disease), 10 were returned, resulting in a response rate of 91%. There were 8 low-grade lesions (5 pilocytic astrocytomas, 1 ganglioglioma, 1 hemangioblastoma, and 1 cavernoma) and 4 high-grade lesions (2 anaplastic gangliogliomas, 1 glioblastoma, and 1 glioneuronal tumor). The mean age at diagnosis was 7.5 years, the mean follow-up was 4.2 years, and 83% of the patients were male. Total resection was achieved in 5 patients and subtotal resection in 7. Four patients had undergone 2 or more resections. The 4 patients with high-grade tumors and 2 with incompletely resected low-grade tumors underwent adjuvant treatment (2 chemotherapy and 4 both radiotherapy and chemotherapy). The mean modified McCormick Scale score at the time of diagnosis was 1.7; at the time of follow-up, 1.5. The mean PedsQL 4.0 total score in the low-grade group was 78.5; in the high-grade group, 82.6. There was no significant difference in PedsQL 4.0 scores between the patient cohort and the normal population. Conclusions In a small cohort of children who had undergone surgery for IMSCTs with a mean follow-up of 4.2 years, quality of life scores according to the PedsQL 4.0 instrument were not different from those in a normal sample population.

show abstract

“…Leptomeningeal dissemination is common with high-grade tumors of the spinal cord [24]. Rates as high as 47-58% have been reported [24].…”

Section: Discussionmentioning

confidence: 99%

Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival

et al. 2012

View full text Add to dashboard Cite

show abstract

Irradiation of Pediatric High-Grade Spinal Cord Tumors

Cited by 34 publications

References 38 publications

Analysis of Risk Factors and Survival in Pediatric High-Grade Spinal Cord Astrocytoma: A Population-Based Study

Analysis of Risk Factors and Survival in Pediatric High-Grade Spinal Cord Astrocytoma: A Population-Based Study

Quality of life after surgical treatment of primary intramedullary spinal cord tumors in children

Pediatric spinal glioblastoma multiforme: current treatment strategies and possible predictors of survival

Contact Info

Product

Resources

About