Irradiation program for candidate 105-N graphites

(3,4-Dihydroxy-phenylamino)-2-imidazoline (DPI), a new potent agonist at dopamine receptors mediating neuronal inhibition

“…On the basis of these results we conclude that DPI is a specific, potent agonist at DI receptors. This specific action is interesting from the point of view of the topography of dopamine receptors (Woodruff, 1971). Moreover, this drug may be a valuable tool for testing the existence of more than one type of dopamine receptor in the mammalian brain as was suggested recently by and Cools, Janssen & others (1975).…”

“…(3,4-Dihydroxy-phenylamino)-2-imidazoline (DPI), a new potent agonist at dopamine receptors mediating neuronal inhibition Dopamine, like noradrenaline, is known to act on sympathetic a-receptors. There is, however, also evidence for the existence of separate dopamine receptors in peripheral mammalian tissues and in the nervous system of both vertebrates and invertebrates (van Rossum, 1966;Woodruff, 1971 ;Goldberg, 1975). We recently showed the existence of two types of dopamine receptors in the brain of the snail Helix aspersa on the basis of differential sensitivity of the respective receptors towards antagonistic drugs (Struyker Boudier & van Rossum, 1974;Struyker Boudier, Gielen 8~ others, 1974).…”