Irrational Use of Antibiotics in Medicine: Crisis of Antibiotic Resistance and what We Can Do

Ильина, С. В.

doi:10.15690/pf.v14i6.1834

Pediatr. farmakol.

2017

DOI: 10.15690/pf.v14i6.1834

|View full text |Cite

Irrational Use of Antibiotics in Medicine: Crisis of Antibiotic Resistance and what We Can Do

С. В. Ильина¹

Abstract: Antibiotic overuse in clinical practice not only leads to an increased amount of healthcare costs and a risk of side effects, but also causes an increase of antimicrobial resistance. This is a global problem and an effective fight bacterial infection depends on its solution. This article provides a brief overview of the primary situations of irrationalНерациональное использование антибиотиков в медицине: кризис антибиотикорезистентности, и что мы можем сделать Иркутский государственный медицинский университет,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

2023

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 21 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Regional Experience in Improving the Quality and Cost-Effectiveness of Medical Care for Children with Acute Respiratory Pathology in the Rostov Region

et al. 2023

View full text Add to dashboard Cite

One of the priorities of the modern world medical community is the continuous comprehensive improvement of medical care quality. Evaluation of medical care quality and material costs level for the management of patients with acute respiratory pathology (ARP) was performed in one city medical facility, as well as cost-effectiveness analysis of the project “Improvement of medical care quality for children of the Rostov region”. The first step of this study was retrospective audit of source medical records (n = 154) of Children’s hospital via the adapted World Health Organization questionnaire “Evaluation of in-patient care quality for children” recommended for Europe and revised in 2015. Inclusion criteria: hospitalization of patients with acute conditions; outcome — recovery with no complications; presence of one of the clinical manifestations (acute nasopharyngitis, acute non-obstructive bronchitis, acute obstructive bronchitis, acute obstructive laryngitis, acute community-acquired pneumonia). The cost-effectiveness evaluation was performed considering the direct treatment costs and the coefficient of economic costs per patient (CECPP). Analysis of the study’s first stage has revealed defects in medical care quality, significant and irrational material costs of the medical facility at all stages of medical and diagnostic care for children with ARP. CECPP peak indicators came under notice in all observation groups due to high expenses on medications and specifically those not included in clinical practice guidelines, vast amount of unreasonable hospitalizations and diagnostic procedures, expenses on physical therapy (PT), etc. Analysis of the study’s second stage medical records (n = 146) of patients with ARP took place after the initial audit followed by quarterly monitoring and hospital staff training (endpoint — 12 months). Significant improvements in the health care quality and cost-effectiveness for children with ARP have been shown.

show abstract

Regional Experience in Improving the Quality and Cost-Effectiveness of Medical Care for Children with Acute Respiratory Pathology in the Rostov Region

et al. 2023

View full text Add to dashboard Cite

show abstract

Assessment of Microbiological Environment and the Level of Antibiotic Resistance in a Multidisciplinary Hospital

Kudlаy

Бакиров

Zaripova

et al. 2022

Tuberk. bolezni lëgk.

View full text Add to dashboard Cite

The objective: to determine the incidence and drug sensitivity of the main pathogens causing community-acquired and nosocomial infections in patients staying in a multidisciplinary hospital.Subjects and Methods: a retrospective study of the microbiological population in patients of a multidisciplinary hospital was carried out. The period over 3 years was assessed. 3,954 samples of biological materials from various sites were studied.Results: gram-positive bacteria prevailed in the general structure of microbial environment of patients – Staphylococcus aureus (28%), and Enterococcus faecalis (10%), as well as gram-negative – Escherichia coli (26%), and Klebsiella pneumoniae (13%). The majority of non-fermenting gram-negative microorganisms isolated from patients in the intensive care unit demonstrated multiple resistance and quantitatively prevailed over those in surgery units. The spectrum of antibiotic susceptibility of microorganisms of the same species isolated from patients of therapy and surgery departments differed.

show abstract

Ceftazidimeavibactam use in children and adolescents

Stetsiouk

Andreeva

Lekmanov

et al. 2021

CMAC

View full text Add to dashboard Cite

The increasing number of infections caused by multidrug-resistant gram-negative bacteria in children is a serious problem all over the world. Ceftazidim-avibactam is a promising antimicrobial drug recently approved in Russia for use in pediatric practice. This review provides information on the possible use of ceftazidime-avibactam in children with complicated intraabdominal infections (in combination with metronidazole); complicated urinary tract infections, including pyelonephritis; hospital-acquired pneumonia, including ventilator-associated pneumonia; infections caused by aerobic gram-negative microorganisms in patients with limited choice of antibacterial therapy. Based on the data on the in vitro activity of the drug, the results of clinical studies of pharmacokinetics, safety and efficacy of ceftazidimeavibactam for the treatment of infections in children the main clinical cases in which the use of ceftazidimeavibactam in pediatric practice is most justified and appropriate are identified.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Irrational Use of Antibiotics in Medicine: Crisis of Antibiotic Resistance and what We Can Do

Cited by 3 publications

References 21 publications

Regional Experience in Improving the Quality and Cost-Effectiveness of Medical Care for Children with Acute Respiratory Pathology in the Rostov Region

Regional Experience in Improving the Quality and Cost-Effectiveness of Medical Care for Children with Acute Respiratory Pathology in the Rostov Region

Assessment of Microbiological Environment and the Level of Antibiotic Resistance in a Multidisciplinary Hospital

Ceftazidimeavibactam use in children and adolescents

Contact Info

Product

Resources

About