This geoecological analysis of Khorezm Province, Uzbekistan, unveils the intricate dynamics of anthropogenic transformations in oasis landscapes. Examining land cover changes, socio-economic influences, hydrological challenges, and biodiversity decline, the study provides comprehensive insights for sustainable development. Urban expansion, driven by factors like population growth and economic development, necessitates strategic urbanization policies, incorporating green infrastructure and mixed-use zoning. Adaptive water management is imperative to address escalating groundwater depletion and declining surface water quality, emphasizing improved irrigation practices and technological integration. Biodiversity conservation initiatives, especially in critical habitats like riparian zones and wetlands, are vital to counteract ecological decline. Predictive modeling facilitates informed decision-making, allowing stakeholders to anticipate and proactively address future landscape changes. Interdisciplinary collaboration is paramount, weaving together perspectives from ecology, hydrology, sociology, and economics to navigate the delicate balance between development and conservation. These findings position Khorezm Province as a potential model for sustainable development, providing valuable insights applicable to regions facing analogous challenges.