Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time

Agréus, Lars; Svärdsudd, Kurt; Nyrén, Olof; Tibblin, Gösta

doi:10.1016/0016-5085(95)90373-9

Cited by 619 publications

(489 citation statements)

References 30 publications

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“…Furthermore, it should be emphasized that our findings were obtained in a work environment characterized by a relatively low level of cement exposure (in no case was the limit of maximal allowed exposure exceeded, data not shown); the prevalence and degree of dyspepsia may be more marked in other contexts with higher exposure levels (20). Interestingly, the prevalence of dyspepsia found for the reference group of unexposed workers was in the range of that reported in other studies of the general population (21,22), a finding suggesting that the increased prevalence observed in the group of exposed workers can be considered correct.…”

Section: Discussionsupporting

confidence: 51%

Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

Coppeta¹,

Pietroiusti²,

Magrini³

et al. 2008

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 51%

Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

Coppeta¹,

Pietroiusti²,

Magrini³

et al. 2008

Scand J Work Environ Health

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“…The results from the single IBS natural history trial (including those in this systematic review) demonstrated that up to 38% of IBS patients did not meet diagnostic criteria for IBS, and reported prolonged symptom-free periods after 1 yr of follow-up, suggesting that IBS patients may develop a "remission" after a series of symptomatic episodes (19). Longitudinal studies have also been done outside the US, and one study in particular bears reporting (24). A Swedish team surveyed individuals on two occasions 1 yr apart, and found symptom onset and disappearance rates similar to those in the previous study in Olmsted County, MN.…”

Section: Ajg -August 2002mentioning

confidence: 92%

The epidemiology of irritable bowel syndrome in North America: a systematic review1

Saito¹,

Schoenfeld²,

Locke³

2002

Am J Gastroenterology

252

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OBJECTIVE:The aim of this study was to systematically review published literature about the prevalence, incidence, and natural history of irritable bowel syndrome (IBS) in North America. METHODS:A computer-assisted search of MEDLINE, EMBASE, and Current Contents/Science Edition databases was performed independently by two investigators. Study selection criteria included: 1) North American populationbased sample of adults; 2) objective diagnostic criteria for IBS (i.e., Rome or Manning criteria); and 3) publication in full manuscript form in English. Eligible articles were reviewed in a duplicate and independent manner. Data extracted were converted into individual tables and presented in descriptive form. RESULTS:The prevalence of IBS in North America ranges from 3% to 20%, with most prevalence estimates ranging from 10% to 15%. The prevalences of diarrhea-predominant and constipation-predominant IBS are both approximately 5%. Published prevalence estimates by gender range from 2:1 female predominance to a ratio of 1:1. Constipationpredominant IBS is more common in female individuals. The prevalence of IBS varies minimally with age. No true population-based incidence studies or natural history studies were found. In one cohort surveyed on two occasions 1 yr apart, 9% of subjects who were free of IBS at baseline reported IBS at follow-up producing an onset rate of 67 per 1000 person-years. In all, 38% of patients meeting criteria for IBS did not meet IBS criteria at 1-yr follow-up. CONCLUSION:Approximately 30 million people in North America meet the diagnostic criteria for IBS. However, data about the natural history of IBS is quite sparse and renewed efforts should be focused at developing appropriately designed trials of the epidemiology of IBS. (Am J Gastroenterol 2002;97:1910 -1915

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“…17 However, the subdivision has also been criticized because of the significant overlap between the symptom subgroupings, the considerable number of patients who do not fit into one of the subgroups, and the lack of adequate value in predicting underlying organic disease. 2,18 Dyspeptic symptoms are often aggravated by food ingestion. Based on questionnaires, up to 75% of dyspeptic patients report a relationship between ingestion of a meal and symptom aggravation, 19,20 and registration of symptoms before and after ingestion of a standardized meal confirmed meal-induced increases in symptom intensity in the majority of patients with functional dyspepsia.…”

Section: Subgroups Of Functional Dyspepsia Patientsmentioning

confidence: 99%

Pathophysiology and Treatment of Functional Dyspepsia

Tack

Lee

2005

Journal of Clinical Gastroenterology

208

247

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Functional dyspepsia is a highly prevalent symptom complex and a heterogenous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms. Therapeutic options are still limited but targeted therapy directed at the underlying pathophysiology seems desirable. Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required.

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Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time

Cited by 619 publications

References 30 publications

Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

The epidemiology of irritable bowel syndrome in North America: a systematic review1

Pathophysiology and Treatment of Functional Dyspepsia

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