Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

Coppeta, Luca; Pietroiusti, Antonio; Magrini, Andrea; Somma, Giuseppina; Bergamaschi, Antonio

doi:10.5271/sjweh.1275

Cited by 9 publications

(9 citation statements)

References 31 publications

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“…As far as the first argument is concerned, only sparse data linking exposure to particulate and functional [ 122 ] or organic [ 123 ] GI diseases are available. Indeed, a systematic investigation of this possible association has not been performed.…”

Section: Impact Of the Inhaled Enm On The Git And Occupational Implicmentioning

confidence: 99%

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

et al. 2017

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Background: There is a fundamental gap of knowledge on the health effects caused by the interaction of engineered nanomaterials (ENM) with the gastro-intestinal tract (GIT). This is partly due to the incomplete knowledge of the complex physical and chemical transformations that ENM undergo in the GIT, and partly to the widespread belief that GIT health effects of ENM are much less relevant than pulmonary effects. However, recent experimental findings, considering the role of new players in gut physiology (e.g. the microbiota), shed light on several outcomes of the interaction ENM/GIT. Along with this new information, there is growing direct and indirect evidence that not only ingested ENM, but also inhaled ENM may impact on the GIT. This fact, which may have relevant implications in occupational setting, has never been taken into consideration. This review paper summarizes the opinions and findings of a multidisciplinary team of experts, focusing on two main aspects of the issue: 1) ENM interactions within the GIT and their possible consequences, and 2) relevance of gastro-intestinal effects of inhaled ENMs. Under point 1, we analyzed how luminal gut-constituents, including mucus, may influence the adherence of ENM to cell surfaces in a size-dependent manner, and how intestinal permeability may be affected by different physico-chemical characteristics of ENM. Cytotoxic, oxidative, genotoxic and inflammatory effects on different GIT cells, as well as effects on microbiota, are also discussed. Concerning point 2, recent studies highlight the relevance of gastro-intestinal handling of inhaled ENM, showing significant excretion with feces of inhaled ENM and supporting the hypothesis that GIT should be considered an important target of extrapulmonary effects of inhaled ENM. Conclusions:In spite of recent insights on the relevance of the GIT as a target for toxic effects of nanoparticles, there is still a major gap in knowledge regarding the impact of the direct versus indirect oral exposure. This fact probably applies also to larger particles and dictates careful consideration in workers, who carry the highest risk of exposure to particulate matter.

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Section: Impact Of the Inhaled Enm On The Git And Occupational Implicmentioning

confidence: 99%

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

et al. 2017

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“…Increased level of consciousness on the adverse health effects of cement dust culminates in scientific research since over two decades ago; an intervention which has been overtly impeded by the dearth of a known model of experimental exposure. Data hitherto analyzed stemmed basically from questionnaires [ [12] , [13] , [14] , [15] , [16] , [17] , 9 ], examination of health/medical records [ 18 , 19 ], interviews [ 16 , 20 , 21 ] and case report [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats

2021

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“…It is also called acid reflux [ 38 ] and has been associated with a poorer quality of life [ 38 , 39 , 40 ]. Alkaline cement dust, one of the major constituents of WTC dust, has been associated in occupational studies with reflux-like dyspepsia but the biological mechanism is not clear [ 41 ]. Barrett’s esophagus, when tissue in the esophagus is replaced by tissue similar to the intestinal lining, is often diagnosed in people with long-term GERD.…”

Section: Resultsmentioning

confidence: 99%

Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster

Gargano

Mantilla

Fairclough

et al. 2018

IJERPH

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After the World Trade Center attacks on 11 September 2001 (9/11), multiple cohorts were developed to monitor the health outcomes of exposure. Respiratory and cancer effects have been covered at length. This current study sought to review the literature on other physical conditions associated with 9/11-exposure. Researchers searched seven databases for literature published in English from 2002 to October 2017, coded, and included articles for health condition outcome, population, 9/11-exposures, and comorbidity. Of the 322 titles and abstracts screened, 30 studies met inclusion criteria, and of these, 28 were from three cohorts: the World Trade Center Health Registry, Fire Department of New York, and World Trade Center Health Consortium. Most studies focused on rescue and recovery workers. While many of the findings were consistent across different populations and supported by objective measures, some of the less studied conditions need additional research to substantiate current findings. In the 16 years after 9/11, longitudinal cohorts have been essential in investigating the health consequences of 9/11-exposure. Longitudinal studies will be vital in furthering our understanding of these emerging conditions, as well as treatment effectiveness.

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Prevalence and characteristics of functional dyspepsia among workers exposed to cement dust

Cited by 9 publications

References 31 publications

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

Standardized experimental model for cement dust exposure; tissue heavy metal bioaccumulation and pulmonary pathological changes in rats

Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster

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