Irritable bowel syndrome; update on pathophysiology and management

Abstract

The functional gastrointestinal disorders (FGID) are symptom-based disorders that cannot be currently explained by definable structural or biochemical causes (1). These disorders are common: the presence of at least one functional GI disorder was identified in 70% of participants in a large US householder survey (2). An associated co-morbid psychiatric condition such as anxiety, mood or panic disorder is seen in up to 60% of those attending gastroenterology outpatient clinics with a functional compliant (3). Functional GI disorders are associated with significant impairment of quality of

Emerging role of probiotics and antimicrobials in the management of irritable bowel syndrome

“…Alterations in the number and type of bacteria in the upper small intestine may result in diarrhea, abdominal bloating and gas, malabsorption, and abdominal pain 24 . Changes in the gut flora inhabiting the colon may lead to the proliferation of bacterial species that produce excess short-chain fatty acids (SCFAs) and gas, such as hydrogen, methane, and carbon dioxide 24,28 . An increase in the concentration of SCFAs may indirectly result in changes in water and electrolyte transport in the colon, resulting in diarrhea 24,28 .…”

“…Changes in the gut flora inhabiting the colon may lead to the proliferation of bacterial species that produce excess short-chain fatty acids (SCFAs) and gas, such as hydrogen, methane, and carbon dioxide 24,28 . An increase in the concentration of SCFAs may indirectly result in changes in water and electrolyte transport in the colon, resulting in diarrhea 24,28 . Increased gas production may potentially result in abdominal bloating and distention 24,28 .…”

“…An increase in the concentration of SCFAs may indirectly result in changes in water and electrolyte transport in the colon, resulting in diarrhea 24,28 . Increased gas production may potentially result in abdominal bloating and distention 24,28 . Notably, increased hydrogen gas production has been associated with IBS-D, whereas increased methane production has been associated with IBS-C 24,29 .…”

Effectiveness of Menthacarin on symptoms of irritable bowel syndrome

“…Moreover, the de novo development of IBS following an episode of bacterial gastroenteritis indicates a potential involvement of a bacterial pathogen in the etiology of the condition [9]. …”

Irritable bowel syndrome in a psychiatristxs practice (the problem of nosological independence) and a possibility of its treatment with antidepressants (in case of paroxetine efficacy)

“…В связи с этим внимания заслуживают антидепрессанты новых поколений, лишенные холинолитической активно-сти. Однако селективные ингибиторы обратного захвата серотонина пока не получили официального одобрения в качестве препаратов для лечения синдрома раздраженного кишечника, хотя в ближайшем будущем это может про-изойти в отношении пароксетина [20].…”