IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population

Arıkoğlu, Hilal; Hepdogru, Melda Aksoy; Kaya, Dudu Erkoç; Aşık, Aycan; İpekçi, Süleyman Hilmi; Iscioglu, Funda

doi:10.1016/j.mgene.2014.07.008

Cited by 27 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However G allele carriers of IRS-1 rs2943641 have a relative risk of 4.336 (95% CI 1.592 -6.43, P = 0.006) for diabetes. Consistent with our results, in Turkish individuals there was no existed relation between this gene and T2D (37). Interestingly, in IRS-1 rs2943641 genotypes, it was observed that the individuals with BMI ≥ 25 (Kg/m 2 ) and aged > 50 years are at greater risk for developing diabetes.…”

Section: Discussionsupporting

confidence: 88%

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

Saravani

Noorzehi

Galavi

et al. 2017

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background: Since insulin receptor substrate-1 (IRS-1) is the main substrate of the insulin receptor tyrosine kinase and has been detected to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a possible candidate for development of type2 diabetes, insulin resistance, and obesity. Preilipin (PLIN) coats intracellular lipid droplets and modulates adipocyte lipolysis. Objectives: In this study, we investigated whether insulin receptor substrate-1 (IRS-1) and Perilipin (PLIN) genes polymorphism were associated with Type 2 diabetes (T2D), obesity, and lipid profiles in a sample of the Iranian population (Southeast of Iran). Methods: In this randomized case-control study (Feb, 2016

show abstract

Section: Discussionsupporting

confidence: 88%

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

Saravani

Noorzehi

Galavi

et al. 2017

Iran Red Crescent Med J

View full text Add to dashboard Cite

show abstract

“…So the dysregulation of IRS1 gene has an important place in the development of insulin resistance. The tyrosine phosphorylation of IRS1 serves as docking molecules for downstream effectors such as phosphatidylinositol 3-kinase and phosphotyrosine phosphatase-2 [15]. However, our study has reached no association between the Gly972Arg polymorphism and the risk of prediabetes in Hanam women.…”

Section: The Association Between the Gly972arg Polymorphism And The Rcontrasting

confidence: 75%

The Association Between the Gly972arg Polymorphism in Irs1 Gene and the Risk of Prediabetes Among Vietnamese Women

Nguyen

2018

MPS

View full text Add to dashboard Cite

Insulin receptor substrate 1 (IRS1) is a ligand of the insulin receptor tyrosine kinase and participates in the insulin receptor signal transduction pathway. Dysregulations in IRS1 expression and function increase incidence of insulin-resistant states such as prediabetes and type 2 diabetes. The study aimed to investigate the association of the Gly972Arg (rs1801278) polymorphism in IRS1 gene with prediabetes in Northern Vietnamese women. The case-control study consisted of 1617 women (250 prediabetic cases and 1367 normoglycemic controls). The IRS1 Gly972Arg polymorphism was genotyped in these subjects using polymerase chain reaction–restriction fragment length polymorphism. The frequency of the ‘‘A’’ allele of the Gly972Arg (G>A) polymorphism was similar between the normal glucose and prediabetic subjects (2.7% and 2.6%, respectively). There was no significant difference in the genotypic frequency between the control and prediabetic cases (P = 0.673). The IRS1 Gly972Arg polymorphism was not associated with the risk of prediabetes in Vietnamese women before and after adjusted for socio-economic, lifestyles and clinical factors (P > 0.05).

show abstract

“…In some studies, such a relationship was found, whereas in others, it was not. There was not significant relationship between the risk of developing type 2 DM and the IRS-1 Gly972Arg gene polymorphism in the Turkish population [59].…”

Section: Resultsmentioning

confidence: 74%

Investigation of the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy in patients with type 2 diabetes mellitus

Alkanlı

Sipahi

et al. 2018

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

The aim of this study was to investigate the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (DM). Our study included 93 patients with type 2 DM diagnosed as having nephropathy and 95 controls diagnosed with type 2 DM without development of DN. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine the genotype distributions of MTHFR, IRS and CALCA gene polymorphisms. The results showed no statistically significant difference between DN patients and type 2 DM controls in

show abstract

IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population

Cited by 27 publications

References 33 publications

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

Association of Perilipin and Insulin Receptor Substrate-1 Genes Polymorphism with Lipid Profiles, Central Obesity, and Type 2 Diabetes in a Sample of an Iranian Population

The Association Between the Gly972arg Polymorphism in Irs1 Gene and the Risk of Prediabetes Among Vietnamese Women

Investigation of the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy in patients with type 2 diabetes mellitus

Contact Info

Product

Resources

About