Is 1-hydroxypyrene a reliable bioindicator of measured dietary polycyclic aromatic hydrocarbon under normal conditions?

Viau, Claude; Diakité, Aı̈ssata; Ruzgytė, Asta; Tuchweber, Béatriz; Blais, Christina; Bouchard, Michèle; Vyskočil, Adolf

doi:10.1016/s0378-4347(01)00465-0

Cited by 56 publications

(35 citation statements)

References 25 publications

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“…The median concentration was lower than those of schoolchildren in Metropolitan Tokyo (roughly 0.1-0.2 ng/ml, Kanoh et al 1993) but consistent with that recently reported for non-smoking Japanese (22.8 nmol/mol cre or 0.044 ng/ml) (Chetiyanukornkul et al 2002). (Note that "mol/mol creatinine" unit value was converted to "ng/ml" unit value assuming daily excretion of creatinine and urine volume to be 1.5 g and 1.5 l, respectively) Higher concentration or greater excretion of 1-OHP has been reported in other studies outside Japan, e.g., approximately 150-180 nmol/ mol cre or 0.3 ng/ml 1-OHP concentration in Netherlands (Van Rooij et al 1994), 157 ng/day in Germany (Scherer et al 2000), or 100-300 ng/day excretion in Canada (Viau et al 2002). Other values of non-smoker from China and European countries cited by Van Rooij et al (1994) ranged from 80 to 680 nmol/mol cre or 0.15 to 1.3 ng/ml.…”

Section: Urinary Excretion Of 1-ohpmentioning

confidence: 64%

“…The possible reason of the lack of correlation was attributed to their inaccurate estimate of dietary B[a]P intake of the subjects which was pointed out by the authors themselves. Viau et al (2002) carried out a controlled feeding trial to Wve Canadian volunteers for Wve consecutive days and related dietary Py exposure, which the authors actually measured, to urinary 1-OHP excretion. They did not Wnd a signiWcant correlation between dietary Py exposure and urinary 1-OHP excretion.…”

Section: Discussionmentioning

confidence: 99%

“…In exposure assessment of PAHs, particularly in occupational exposure assessment, urinary 1-hydroxypyrene (1-OHP), a metabolite of one of the major PAHs, pyrene, has been employed as a biomarker. However, the utility of 1-OHP as an indicator of PAHs exposure in general population has been controversial: Van Rooij et al (1994) found a signiWcant relationship between dietary intake level of pyrene and daily urinary excretion level of 1-OHP whereas Scherer et al (2000) and Viau et al (2002) did not.…”

Section: Introductionmentioning

confidence: 99%

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Inhalation and dietary exposure to polycyclic aromatic hydrocarbons and urinary 1-hydroxypyrene in non-smoking university students

Suzuki

Yoshinaga

2007

Int Arch Occup Environ Health

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Section: Urinary Excretion Of 1-ohpmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhalation and dietary exposure to polycyclic aromatic hydrocarbons and urinary 1-hydroxypyrene in non-smoking university students

Suzuki

Yoshinaga

2007

Int Arch Occup Environ Health

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“…The observed variability in the relationship of grilled/ broiled meat consumption across individual PAH metabolites in urine may be explained by interindividual variation in doses and bioavailability of ingested PAHs, and possibly by interindividual variation in genetic polymorphisms that encode enzymes involved in PAH biotransformation as suggested by Rihs et al (60,(62)(63)(64)(65). Alternatively, the induction of metabolizing enzymes through chronic exposure could lead to differential metabolism of individual PAHs.…”

Section: Pah Exposure-comparison With Other Countriesmentioning

confidence: 97%

Involuntary Tobacco Smoke Exposure and Urinary Levels of Polycyclic Aromatic Hydrocarbons in the United States, 1999 to 2002

Suwan-ampai

Navas‐Acien

Strickland

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Evidence supports active smoking as a major source of exposure to polycyclic aromatic hydrocarbons (PAH), compounds that are mutagenic and carcinogenic in humans. The influence of involuntary exposure to tobacco smoke on PAH exposure levels among nonsmokers, however, is unknown. This study evaluated the association between both active and involuntary tobacco smoke and biomarkers of PAH exposure in the general U.S. population. A cross-sectional analysis of 5,060 participants z6 years of age was done using data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES). PAH exposure was measured by urinary concentrations of 23 monohydroxylated metabolites of nine PAH compounds. Tobacco smoke exposure was defined as no exposure, involuntary exposure, and active exposure by combining serum cotinine levels, smoking status, and presence of household smokers. PAH metabolite levels ranged from 33.9 ng/L for 9-hydroxyphenanthrene to 2,465.4 ng/L for 2-hydroxynaphthalene. After adjustment for age, sex, race/ethnicity, education, household income, and broiled/grilled food consumption, participants involuntarily and actively exposed to tobacco smoke had urinary metabolite concentrations that were increased by a factor of 1.1 to 1.4 and 1.5 to 6.9, respectively, compared with unexposed participants. Associations for involuntary smoking were stronger and statistically significant for 1-hydroxypyrene, 2-hydroxyfluorene, 3-hydroxyfluorene, 9-hydroxyfluorene, 1-hydroxyphenanthrene, 2-hydroxyphenanthrene, and 3-hydroxyphenanthrene compared with other metabolites. Involuntary exposure to tobacco smoke was associated with elevated urinary concentrations of most PAH metabolites in a representative sample of the U.S. population. Policy and educational efforts must continue to minimize PAH exposure through active and involuntary tobacco smoke exposure. (Cancer Epidemiol Biomarkers Prev 2009;18(3):884 -93)

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“…38 We calculated the ingested dose based only on the barbecued chicken, and did not measure PAH contents in the sauce and side dishes, which resulted in an underestimate of the actual ingested amount.…”

Section: Excreted Metabolite Amounts In Comparison To Ingested Pahsmentioning

confidence: 99%

Excretion Profiles and Half-Lives of Ten Urinary Polycyclic Aromatic Hydrocarbon Metabolites after Dietary Exposure

Romanoff

Bartell

et al. 2012

Chem. Res. Toxicol.

184

130

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Human exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed by biomonitoring of their urinary mono-hydroxylated metabolites (OH-PAHs). Limited information exists on the human pharmacokinetics of OH-PAHs. This study aimed to investigate the excretion half-life of 1-hydroxypyrene (1-PYR), the most used biomarker for PAH exposure, and 9 other OH-PAHs following a dietary exposure in 9 non-smoking volunteers with no occupational exposure to PAHs. Each person avoided food with known high PAH-content during the study period, except for a high PAH-containing lunch (barbecued chicken) on the first day. Individual urine samples (n = 217) were collected from 15 hours before to 60 hours following the dietary exposure. Levels of all OH-PAHs in all subjects increased rapidly by 9-141 fold after the exposure, followed by a decrease consistent with first order kinetics, and returned to background levels 24-48 hours after the exposure. The average time to reach maximal concentration ranged from 3.1 h (1-naphthol) to 5.5 h (1-PYR). Creatinine-adjusted urine concentrations for each metabolite were analyzed using a non-linear mixed effects model including a term to estimate background exposure. The background-adjusted half-life estimate was 3.9 h for 1-PYR and ranged 2.5-6.1 h for the other 9 OH-PAHs, which in general, were shorter than those previously reported. The maximum concentrations after the barbecued chicken consumption were comparable to the levels found in reported occupational settings with known high PAH exposures. It is essential to consider the relatively short half-life, the timing of samples relative to exposures, and the effect of diet when conducting PAH exposure biomonitoring studies.

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Is 1-hydroxypyrene a reliable bioindicator of measured dietary polycyclic aromatic hydrocarbon under normal conditions?

Cited by 56 publications

References 25 publications

Inhalation and dietary exposure to polycyclic aromatic hydrocarbons and urinary 1-hydroxypyrene in non-smoking university students

Inhalation and dietary exposure to polycyclic aromatic hydrocarbons and urinary 1-hydroxypyrene in non-smoking university students

Involuntary Tobacco Smoke Exposure and Urinary Levels of Polycyclic Aromatic Hydrocarbons in the United States, 1999 to 2002

Excretion Profiles and Half-Lives of Ten Urinary Polycyclic Aromatic Hydrocarbon Metabolites after Dietary Exposure

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