Is 99mTc-HMPAO-leukocyte imaging an accurate method in evaluating therapy result in prosthetic joint infection and diagnosing suspected chronic prosthetic joint infection?

Teiler, Johan; Ahl, Marcus; Åkerlund, Börje; Wird, Sara; Brismar, Hjalmar; Bjäreback, Annie; Hedlund, Håkan; Holstensson, Maria; Axelsson, Rimma

doi:10.23736/s1824-4785.19.03040-1

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…At present, the distinction between infection and sterile inflammation is of great significance. A variety of radiopharmaceuticals have been developed to detect inflammation [9][10][11][12][13][14][15][16][17][18][19]. For example, 18 F-2-Fluoro-2-deoxy-D-glucose ([ 18 F]FDG) have already been used for infection imaging in clinics.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Evaluation of Novel Norfloxacin Isonitrile 99mTc Complexes as Potential Bacterial Infection Imaging Agents

et al. 2021

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To develop potential technetium-99m single-photon emission computed tomography (SPECT) imaging agents for bacterial infection imaging, the novel norfloxacin isonitrile derivatives CN4NF and CN5NF were synthesized and radiolabeled with a [99mTc][Tc(I)]+ core to obtain [99mTc]Tc-CN4NF and [99mTc]Tc-CN5NF. These compounds were produced in high radiolabeling yields and showed hydrophilicity and good stability in vitro. The bacterial binding assay indicated that [99mTc]Tc-CN4NF and [99mTc]Tc-CN5NF were specific to bacteria. Compared with [99mTc]Tc-CN4NF, biodistribution studies of [99mTc]Tc-CN5NF showed a higher uptake in bacteria-infected tissues than in turpentine-induced abscesses, indicating that [99mTc]Tc-CN5NF could distinguish bacterial infection from sterile inflammation. In addition, [99mTc]Tc-CN5NF had higher abscess/blood and abscess/muscle ratios. SPECT image of [99mTc]Tc-CN5NF showed that there was a clear accumulation in the infection site, suggesting that it could be a potential bacterial infection imaging radiotracer.

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Section: Introductionmentioning

confidence: 99%

“…A variety of radiopharmaceuticals have been developed to detect inflammation [9][10][11][12][13][14][15][16][17][18][19]. For example, 18 F-2-Fluoro-2-deoxy-D-glucose ([ 18 F]FDG) have already been used for infection imaging in clinics. However, it cannot distinguish between bacterial infection and sterile inflammation [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of Novel Norfloxacin Isonitrile 99mTc Complexes as Potential Bacterial Infection Imaging Agents

et al. 2021

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“…Indeed, 111 In-oxine has been used in clinical practice for more than 30 years to radiolabel white blood cells (WBC) for imaging of infection and inflammation (Roca et al 2010;Teiler et al 2020). Oxine is a lipophilic molecule that chelates indium-111 and is able to freely diffuse inside the cell through the plasma membrane.…”

Section: Nuclear Medicine Imagingmentioning

confidence: 99%

Immune cell labelling and tracking: implications for adoptive cell transfer therapies

Galli

Varani

Lauri

et al. 2021

EJNMMI radiopharm. chem.

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Background The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer. In addition to conventional drugs, new cell-based therapies, like adoptive cell transfer, proved to be successful in humans. Indeed, after the approval of anti-CD19 CAR-T cell therapy, researchers are trying to extend this approach to other cancer or cell types. Main body This review focuses on the different approaches to non-invasively monitor the biodistribution, trafficking and fate of immune therapeutic cells, evaluating their efficacy at preclinical and clinical stages. PubMed and Scopus databases were searched for published articles on the imaging of cell tracking in humans and preclinical models. Conclusion Labelling specific immune cell subtypes with specific radiopharmaceuticals, contrast agents or optical probes can elucidate new biological mechanisms or predict therapeutic outcome of adoptive cell transfer therapies. To date, no technique is considered the gold standard to image immune cells in adoptive cell transfer therapies.

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“…Several systematic reviews and meta-analyses have been published indicating that WBC scans-if necessary, combined with a bone marrow scan-have very high specificity for identifying peri-prosthetic joint infection versus aseptic loosening [55][56][57][58][59][60], thus representing the most reliable imaging tool able to achieve this differentiation. The reported accuracy of the use of combined WBC scintigraphy (using either 99m Tc-HMPAO-WBC or 111 In-oxine-WBC) and bone marrow scintigraphy ranges from 83% to 98% for both hip and knee prosthesis infections [34].…”

Section: What Is the Role Of A Wbc Scan To Diagnose A Pji (Is A Negatmentioning

confidence: 99%

The Role of Imaging Techniques to Define a Peri-Prosthetic Hip and Knee Joint Infection: Multidisciplinary Consensus Statements

Romanò

Petrosillo

Argento

et al. 2020

JCM

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Diagnosing a peri-prosthetic joint infection (PJI) remains challenging despite the availability of a variety of clinical signs, serum and synovial markers, imaging techniques, microbiological and histological findings. Moreover, the one and only true definition of PJI does not exist, which is reflected by the existence of at least six different definitions by independent societies. These definitions are composed of major and minor criteria for defining a PJI, but most of them do not include imaging techniques. This paper highlights the pros and cons of available imaging techniques—X-ray, ultrasound, computed tomography (CT), Magnetic Resonance Imaging (MRI), bone scintigraphy, white blood cell scintigraphy (WBC), anti-granulocyte scintigraphy, and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), discusses the added value of hybrid camera systems—single photon emission tomography/computed tomography (SPECT/CT), PET/CT and PET/MRI and reports consensus answers on important clinical questions that were discussed during the Third European Congress on Inflammation/Infection Imaging in Rome, December 2019.

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Is 99mTc-HMPAO-leukocyte imaging an accurate method in evaluating therapy result in prosthetic joint infection and diagnosing suspected chronic prosthetic joint infection?

Cited by 11 publications

References 30 publications

Synthesis and Evaluation of Novel Norfloxacin Isonitrile 99mTc Complexes as Potential Bacterial Infection Imaging Agents

Synthesis and Evaluation of Novel Norfloxacin Isonitrile 99mTc Complexes as Potential Bacterial Infection Imaging Agents

Immune cell labelling and tracking: implications for adoptive cell transfer therapies

The Role of Imaging Techniques to Define a Peri-Prosthetic Hip and Knee Joint Infection: Multidisciplinary Consensus Statements

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