Is a 7-day Helicobater pylori treatment enough for eradication and inactivation of gastric inflammatory activity?

Abstract

In this Ecuadorian population, the 10-d therapy was more effective than the 7-d therapy for H pylori eradication as well as for gastric mucosa inflammatory inactivation.

Clinical trial: irsogladine maleate, a mucosal protective drug, accelerates gastric ulcer healing after treatment for eradication of Helicobacter pylori infection – the results of a multicentre, double‐blind, randomized clinical trial (IMPACT study)

“…The low healing rate of 26.1% among patients in the placebo group in whom eradication treatment had failed suggested that eradication alone followed by observation and no further treatment is potentially risky. Whereas the eradication rate in this study was relatively high (85.6%), this rate has been decreasing in recent years in clinical practice 33 and is now reported to be below 80% in most places 34 or even below 70% in some places 33 . Therefore, it is likely that additional treatment of the ulcer during the period from immediately after eradication until the assessment of eradication will be warranted in the future.…”

Tratamiento ideal del Helicobacter pylori: una revisión sistemática

“…Basados en las observaciones de nuestra revisión, la triple terapia estándar como esquema de primera línea de una semana de duración muestra tasas subóptimas de erradicación en países como Turquía, Colombia, Ecuador, Japón y Estados Unidos 24,26,41,43,50 . Sin embargo, en otros países, como Brasil y Reino Unido, las tasas de erradicación fueron superiores 19,51 , siendo estos resultados similares a los obtenidos en países con bajas tasas de resistencia a claritromicina (menor del 15 al 20%).…”

Ideal treatment for Helicobacter pylori: A systematic review

“…24,26,41,43,50 However, in other countries such as Brazil and the United Kingdom, the eradication rates were higher; 19,51 these results were similar to those obtained in the countries with low rates of resistance to clarithromycin (lower than 15 to 20%). Moreover, with therapies lasting longer than 7 days, greater eradication effectiveness was not found in countries that included the United States, Colombia, and Chile.…”

“…39 And finally, in the Spanish population, the triple therapy with ranitidine bismuth citrate (RBC), tetracycline, and metronidazole versus the triple therapy with levofloxacin were effective in 69 and 71%, respectively, with no statistically significant differences. 40 Of the Latin American randomized clinical experiments included in the study, the following eradication rates for the clarithromycinbased standard triple therapy as first-line treatment were obtained: in Colombia, the effectiveness of 7-day versus 14-day treatment reached ITT eradication rates of 67.8 and 74.3%, respectively; 41 in Chile, 7-day versus 14-day treatment had rates of 78.3 and 85.5%; 42 in Ecuador, 7-day versus 10-day treatment, 68.3 and 83.8%; 43 and in Brazil, the standard triple therapy with clarithromycin versus a control group (PPI plus placebo), both of 10-day duration, had rates of 88.6 and 7.4%, respectively. 44 As second-line therapy, in Colombia, the 14-day clarithromycin-based triple therapy with lansoprazole versus omeprazole reached eradication rates of 69 and 70% in each respective regimen, with no statistically significant difference.…”