Is a Marginal Excision Relevant after Preoperative Radiation Therapy for Soft Tissue Sarcoma of the Extremity?

Dagan, Roi; McGee, L.A.; Morris, C.G.; Knapik, Jacquelyn A.; Jd, Reith; Scarborough, M.T; Gibbs, Charles P.; Marcus, R B; Zlotecki, Robert A.; Indelicato, Daniel J.

doi:10.1016/j.ijrobp.2010.07.231

Cited by 3 publications

(2 citation statements)

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“…Randomized controlled trials have suggested that radiation may decrease the rates of local recurrence following surgery in ESTS, particularly in high-grade tumors [ 8 , 30 ]. Several studies have attempted to correlate the relative benefit of radiation therapy for local control to various patient- and tumor-related factors, including tumor grade, size, depth relative to the fascia, and surgical margin status, suggesting that each of the factors are important in determining optimal treatment [ 9 , 31 – 33 ]. Among the limitations of the current study is the inability to fully assess margin status or to fully evaluate the local recurrence rates, as these are factors that continue to spark controversy regarding their influence on overall survival in ESTS.…”

Section: Discussionmentioning

confidence: 99%

Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years

Jacobs

Michels

Stein

et al. 2015

Sarcoma

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Several patient demographic factors, including marital status, have been demonstrated to have prognostic significance for survival in extremity soft tissue sarcoma (ESTS). A study population of 12,546 adult patients diagnosed with ESTS from 1991 to 2010 was identified from the SEER database, a large population-based registry, in order to determine whether overall survival had changed over this recent 20-year period. The study population was divided into three groups by year of diagnosis: 1991–1996, 1997–2003, and 2004–2010. We used the Kaplan-Meier method and Cox proportional hazards regression to assess survival differences between different demographic groups and prognostic clinical characteristics. Over the course of time, the 5-year overall survival rates have increased from 28% in the earliest time period to 62% in the latest (P < 0.0001). On multivariate analysis, the mortality rate progressively declined from the 1991–1996 group (HR: 3.02, CI: 2.78–3.29) to the 1997–2003 group (HR: 2.21, CI: 2.06–2.37), with the 2004–2010 group having the best overall survival, despite increases in the proportion of patients with tumors greater than 5 cm in size (P < 0.0001), and those presenting with metastasis (P < 0.0001).

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Section: Discussionmentioning

confidence: 99%

Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years

Jacobs

Michels

Stein

et al. 2015

Sarcoma

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“…By margin status, local failure at 5 years was 31, 14, 6 and 5% for contaminated, positive, marginal and negative margins, respectively. This study demonstrated the effectiveness of preoperative irradiation to sterilize microscopic extension of disease in patients with negative and close margin status [17].…”

Section: Marginsmentioning

confidence: 68%

Perioperative irradiation in extremity soft tissue sarcoma

Mahmoud

Wolfson

2011

Expert Review of Anticancer Therapy

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Adjuvant radiotherapy constitutes an important component of the treatment of soft tissue sarcomas. Extremity soft tissue sarcomas constitute a large proportion of this rare mesenchymal tumor. Questions regarding timing, techniques and toxicity come into play about optimizing adjuvant radiotherapy. This article will discuss recent trends and outcomes of perioperative, that is, preoperative and postoperative, irradiation.

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Long-Term Results Following Postoperative Radiotherapy for Soft Tissue Sarcomas of the Extremity

McGee

Indelicato

Dagan

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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Is a Marginal Excision Relevant after Preoperative Radiation Therapy for Soft Tissue Sarcoma of the Extremity?

Cited by 3 publications

References 0 publications

Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years

Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years

Perioperative irradiation in extremity soft tissue sarcoma

Long-Term Results Following Postoperative Radiotherapy for Soft Tissue Sarcomas of the Extremity

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