Is a reduction in residual volume a sub-clinical manifestation of hydrogen sulfide intoxication?

Buick, J. B.; Lowry, R. C.; Magee, T.R.

doi:10.1002/(sici)1097-0274(200003)37:3<296::aid-ajim8>3.0.co;2-2

Cited by 16 publications

(4 citation statements)

References 4 publications

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“…Our observation of small airway changes in association with a synergistic effect of PM 2.5 and other hazardous gases is also substantiated by other studies describing the impact of PM 2.5 on small airway function [56,60]. It must be remembered that gases that have low solubilities, such as oxides of nitrogen and sulfur and particulate matters of very small aerodynamic diameter (PM 2.5 ), can reach up to the alveoli and terminal bronchioles without affecting the central airways to an observable extent [61]. This supports our findings of a significant association between higher exposure to air pollution and lower RV but no other lung function variables.…”

Section: Discussionsupporting

confidence: 91%

Short-Term Acute Exposure to Wildfire Smoke and Lung Function among Royal Canadian Mounted Police (RCMP) Officers

Moitra

Tabrizi

Fathy³

et al. 2021

IJERPH

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The increasing incidence of extreme wildfire is becoming a concern for public health. Although long-term exposure to wildfire smoke is associated with respiratory illnesses, reports on the association between short-term occupational exposure to wildfire smoke and lung function remain scarce. In this cross-sectional study, we analyzed data from 218 Royal Canadian Mounted Police officers (mean age: 38 ± 9 years) deployed at the Fort McMurray wildfires in 2016. Individual exposure to air pollutants was calculated by integrating the duration of exposure with the air quality parameters obtained from the nearest air quality monitoring station during the phase of deployment. Lung function was measured using spirometry and body plethysmography. Association between exposure and lung function was examined using principal component linear regression analysis, adjusting for potential confounders. In our findings, the participants were predominantly male (71%). Mean forced expiratory volume in 1 s (FEV1), and residual volume (RV) were 76.5 ± 5.9 and 80.1 ± 19.5 (% predicted). A marginal association was observed between air pollution and higher RV [β: 1.55; 95% CI: −0.28 to 3.37 per interquartile change of air pollution index], but not with other lung function indices. The association between air pollution index and RV was significantly higher in participants who were screened within the first three months of deployment (2.80; 0.91 to 4.70) than those screened later (−0.28; −2.58 to 2.03), indicating a stronger effect of air pollution on peripheral airways. Acute short-term exposure to wildfire-associated air pollutants may impose subtle but clinically important deleterious respiratory effects, particularly in the peripheral airways.

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Section: Discussionsupporting

confidence: 91%

Short-Term Acute Exposure to Wildfire Smoke and Lung Function among Royal Canadian Mounted Police (RCMP) Officers

Moitra

Tabrizi

Fathy³

et al. 2021

IJERPH

View full text Add to dashboard Cite

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“…Epidemiologic study results have been mixed. Studies have been carried out in H 2 S-exposed populations living near natural gas refineries [ 2 , 3 ], paper mills [ 4 ], or concentrated animal feeding operations [ 5 , 6 ] and in sewer workers [ 7 ] and workers at an aircraft factory [ 8 ]. Some have reported decrements in lung function or residual volume; others have found no evidence of an association.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Hydrogen Sulfide Exposure and Lung Function, Asthma and Chronic Obstructive Pulmonary Disease in a Geothermal Area of New Zealand

et al. 2015

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BackgroundResults have been conflicting whether long-term ambient hydrogen sulfide (H2S) affects lung function or is a risk factor for asthma or chronic obstructive pulmonary disease (COPD). Rotorua city, New Zealand, has the world’s largest population exposed to ambient H2S—from geothermal sources.ObjectivesWe investigated associations of H2S with lung function, COPD and asthma in this population.Methods1,204 of 1,639 study participants, aged 18–65 years during 2008–2010, provided satisfactory spirometry results. Residences, workplaces and schools over the last 30 years were geocoded. Exposures were estimated from data collected by summer and winter H2S monitoring networks across Rotorua. Four metrics for H2S exposure, representing both current and long-term (last 30 years) exposure, and also time-weighted average and peak exposures, were calculated. Departures from expected values for pre-bronchodilator lung function, calculated from prediction equations, were outcomes for linear regression models using quartiles of the H2S exposure metrics. Separate models examined participants with and without evidence of asthma or COPD, and never- and ever-smokers. Logistic regression was used to investigate associations of COPD (a post-bronchodilator FEV1/FVC < 70% of expected) and asthma (doctor-diagnosed or by FEV1 response to bronchodilator) with H2S exposure quartiles.ResultsNone of the exposure metrics produced evidence of lung function decrement. The logistic regression analysis showed no evidence that long-term H2S exposure at Rotorua levels was associated with either increased COPD or asthma risk. Some results suggested that recent ambient H2S exposures were beneficially associated with lung function parameters.ConclusionsThe study found no evidence of reductions in lung function, or increased risk of COPD or asthma, from recent or long-term H2S exposure at the relatively high ambient concentrations found in Rotorua. Suggestions of improved lung function associated with recent ambient H2S exposures require confirmation in other studies.

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“…39,40 However, other studies have suggested that a reduction in residual volume is a subclinical effect. 41 If so, this may be related to effects on pulmonary receptors and reflex activity rather than lung mechanics. 42,43…”

Section: Acute Respiratory Effectsmentioning

confidence: 99%

Hydrogen Sulfide

Guidotti¹

2010

Int J Toxicol

324

123

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Hydrogen sulfide is a relatively common, frequently lethal, and unique occupational hazard for which research since 1990 has uncovered many anomalies and subtleties and a previously unsuspected physiological role for the endogenous agent. The result has been uncertainty and misunderstanding, particularly for persons new to the literature. This review addresses evidence that settles past controversies, guides practical issues in evaluating human toxicity, addresses unresolved issues involving chronic exposure, and points the way to a deeper understanding of the agent and its effects.

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Is a reduction in residual volume a sub-clinical manifestation of hydrogen sulfide intoxication?

Cited by 16 publications

References 4 publications

Short-Term Acute Exposure to Wildfire Smoke and Lung Function among Royal Canadian Mounted Police (RCMP) Officers

Short-Term Acute Exposure to Wildfire Smoke and Lung Function among Royal Canadian Mounted Police (RCMP) Officers

Investigation of Hydrogen Sulfide Exposure and Lung Function, Asthma and Chronic Obstructive Pulmonary Disease in a Geothermal Area of New Zealand

Hydrogen Sulfide

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