Is Age Associated with the Number or Types of Medications Prescribed to Renal Transplant Recipients?

Chisholm, Marie A.; Melroy, Joel; Johnson, Maribeth H.; Mulloy, Laura L.; Spivey, Christina A.

doi:10.1111/j.1532-5415.2007.01077.x

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…Multiple chronic illnesses demand complex, long-term medication regimens. Renal transplant recipients aged 65 years and older take an average of 12.40 medications (Chisholm, Melroy, Johnson, Malloy, & Spivey, 2008). Social isolation; changes in vision, memory, and manual dexterity; and other physical limitations may occur in older adults (Frewin, Chryssidis, & Howard, 1982;Kendrick & Bayne, 1982;McGraw & Drennan, 2001).…”

Section: Problemmentioning

confidence: 99%

Medication Adherence in Older Renal Transplant Recipients

et al. 2010

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This project examined patterns, predictors, and outcomes of medication adherence in a convenience sample of 37 renal transplant recipients aged 55 years or older in a Mid-Southern U.S. facility using an exploratory, descriptive, longitudinal design. Electronic monitoring was conducted for 12 months using the Medication Event Monitoring System. An alarming 86% of the participants were nonadherent with medications. Four clusters of medication taking and timing patterns were identified with evening doses presenting particular challenges. Depression, self-efficacy, social support, and medication side effects did not predict medication adherence. There was no significant difference in medication adherence scores between those with and without infections. Medication adherence pattern data from electronic monitoring provides an opportunity for health care professionals to move away from blaming the patient by attempting to identify predictors for medication nonadherence. Medication dose taking and timing patterns could be explored with patients so that medication adherence interventions could target specific patient patterns.

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Section: Problemmentioning

confidence: 99%

Medication Adherence in Older Renal Transplant Recipients

et al. 2010

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“…Elderly patients are more prone to polypharmacy and drug rationalization is recommended (29). Additonally, drug pharmacology and metabolism are altered with age.…”

Section: Posttransplantation Problems Specific To Elderly Patientsmentioning

confidence: 99%

“…One commonly seen example is the gradual age‐related decline in cytochrome P450 activity. Cytochrome P450 is responsible for the removal of both steroid and cyclosporine, and a decreased volume of distribution for lipid‐soluble drugs (29, 30). Consequently, elderly patients are more prone to the side‐effects of calcineurin inhibitors and dose modification may be required.…”

Section: Posttransplantation Problems Specific To Elderly Patientsmentioning

confidence: 99%