Is age during bronchiolitis the most important predictor of post‐bronchiolitis outcome?

Korppi, Matti

doi:10.1111/apa.16205

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…The diagnosis of bronchiolitis has usually been limited to the first-time wheezing episode, and the upper age limit has been 12 months in Europe and 24 months in America 8,9 . Infants diagnosed with bronchiolitis during the first year of life differ from those diagnosed at a later age for clinical characteristics, viral findings, and immediate and later outcomes, although there is a grey area before and after 12 months of age 10 . In Europe, repeated wheezing at age <12 months and first wheezing at age >12 months have been called as wheezy (wheezing) bronchitis.…”

Section: Wheezing In Childhood -Definitionsmentioning

confidence: 99%

Asthma and Lung Function in Adulthood After Early-Childhood Wheezing

Korppi

2022

MRAJ

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The risk of asthma and lung function reduction is increased in children who have presented with wheezing associated with respiratory tract infection in early childhood. Three prospective cohort studies consisting of patients hospitalized for infection-associated wheezing at <24 months of age, which started in Finland and Sweden in the 1980`s and 1990`s, have reported outcomes at >25 years of age. These three cohorts are even globally the only cohorts consisting of early-childhood wheezers followed prospectively until adulthood. Initially, the studies were not controlled, and the risk of asthma and reduced lung function and the risk factors in question were assessed by analyses within the cohorts. Matched population-based controls without wheezing history in early childhood were recruited for the studies in adulthood. One follow-up included only questionnaire data without lung function results. Two studies included control visits, and one of them presented clinical and lung function data, and the other clinical and bronchial reactivity data. Respiratory syncytial virus was identified on admission in all three post-wheezing cohorts, and rhinoviruses in the newest cohort from the 1990`s. The present narrative review summarizes data on asthma and lung function reduction in adults aged >25 years after hospitalization for wheezing at age <24 months compared to population-based controls in the three until now published prospective post-wheezing cohorts. The frequency of doctor-diagnosed asthma varied from 10.3% to 36.6%, and that of self-reported symptom-based asthma from 35.4% to 40.7%. The differences between cases and controls were significant and robust to adjustments with current smoking and allergic rhinitis, which were associated with asthma in all cohorts. One cohort study reported lung function results, and both baseline and post-bronchodilator forced expiratory volumes were lower in cases than in controls. About 10-15% of former early-childhood wheezers presented with irreversible lung function reduction characteristic to chronic obstructive lung disease. Family asthma was associated with current asthma, but other early risk factors, with exception of blood eosinophilia in one cohort, were not anymore predictive. In conclusion, hospitalization for infection-associated wheezing at <24 months of age was an independently significant risk factor of asthma in adults at >25 years of age.

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Section: Wheezing In Childhood -Definitionsmentioning

confidence: 99%

Asthma and Lung Function in Adulthood After Early-Childhood Wheezing

Korppi

2022

MRAJ

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Asthma and health-related quality of life at 16–20 years of age in a prospectively followed post-bronchiolitis cohort

Laitinen,

Lauhkonen,

Saarikallio

et al. 2024

Eur J Pediatr

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The aim was to evaluate asthma and health-related quality of life (HRQoL) outcomes in adolescents, after hospital-treated bronchiolitis experienced in less than 6 months of age. A prospective cohort study started in 2001–2004 and followed up 166 children hospitalised for bronchiolitis in early infancy. At 16–20 years of age, 76 cases and 41 population-based controls without a history of bronchiolitis participated in the current study. Clinical asthma, presumptive symptoms and HRQoL data were collected with a structured questionnaire and the St. Georges Respiratory Questionnaire (SGRQ). Flow-volume spirometry was measured before and after bronchodilator administration. Asthma was present in 21.1% of cases in the post-bronchiolitis cohort compared to 9.8% in the control group (p = 0.21). Also, 35.5% of cases and 19.5% of controls reported dyspnea during the last 12 months (p = 0.04). In addition, total SGRQ scores were higher in the bronchiolitis group (4.26) than in the control group (1.67, p < 0.001) referring to a reduced health-related quality of life. Conclusion: Viral bronchiolitis in early infancy was associated with increased respiratory symptoms and lower health-related quality of life at age 16–20 years. What is known:• The prevalence of asthma at the school age and adolescence is increased after hospitalisation required bronchiolitis in infancy compared to those without hospitalisation due to bronchiolitis. What is new:• Viral bronchiolitis requiring hospitalisation in early infancy was associated with increased respiratory symptoms, such as dyspnoea, and lower health-related quality of life at age 16–20 years in a prospectively followed post-bronchiolitis cohort.

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Is age during bronchiolitis the most important predictor of post‐bronchiolitis outcome?

Cited by 3 publications

References 6 publications

Asthma and Lung Function in Adulthood After Early-Childhood Wheezing

Asthma and Lung Function in Adulthood After Early-Childhood Wheezing

Asthma and health-related quality of life at 16–20 years of age in a prospectively followed post-bronchiolitis cohort

Is age during bronchiolitis the most important predictor of post‐bronchiolitis outcome?

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