1995
DOI: 10.1042/cs0880359
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Is Allopurinol Beneficial in the Prevention of Renal Ischaemia—Reperfusion Injury in the Rat?: Evaluation by Near-Infrared Spectroscopy

Abstract: 1. The role of allopurinol in the protection of kidney function following ischaemia-reperfusion injury has been investigated using the novel technique of nearinfrared spectroscopy.2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. 3. Allopurinol infusion increased the rate of reperfu sion of oxygenated blood seen in control rats (P < 0.05).4. Allopurinol enhanced the rate of tissue oxygena tion during e… Show more

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Cited by 19 publications
(6 citation statements)
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References 24 publications
(29 reference statements)
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“…The role of xanthine oxidase in postischaemic reperfusion injury and the benefit of its inhibition remain controversial [27, 28, 29, 30, 31, 32, 33, 34, 35, 36]. In our model by applying allopurinol, a potent xanthine oxidase inhibitor, we were not able to prevent polyribosome breakdown.…”
Section: Discussionmentioning
confidence: 57%
“…The role of xanthine oxidase in postischaemic reperfusion injury and the benefit of its inhibition remain controversial [27, 28, 29, 30, 31, 32, 33, 34, 35, 36]. In our model by applying allopurinol, a potent xanthine oxidase inhibitor, we were not able to prevent polyribosome breakdown.…”
Section: Discussionmentioning
confidence: 57%
“…These results are consistent with those of earlier in vivo studies where allopurinol pretreatment provided functional protection against injury. [24][25][26][27] Allopurinol is rapidly converted by xanthine oxidase (XO) to its major metabolite oxypurinol, thereby inhibiting both XO-mediated conversion of hypoxanthine to xanthine and xanthine to uric acid and the accompanying generation of O . À 2 .…”
Section: Discussionmentioning
confidence: 99%
“…Their potentiating effect in combination may be due to their different mechanisms of action, which are not very well understood. Recently, new methods, including enzyme concentrations in tissue sections [25], infrared spectroscopy [26] and intravital microscopy [27], were used to evaluate the degree of renal reperfusion injury. With these methods, further evaluation of pathologic mechanisms will be possible.…”
Section: Discussionmentioning
confidence: 99%