Is analysis of the reticulocyte haemoglobin equivalent a useful test for the diagnosis of iron deficiency anaemia in geriatric patients?

Joosten, Etienne; Lioen, Pieter; Brusselmans, Caroline; Indevuyst, Christophe; Boeckx, Nancy

doi:10.1016/j.ejim.2012.09.001

Cited by 33 publications

(42 citation statements)

References 31 publications

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“…We found that the sensitivity of the CHr was not superior to the MCH parameter or the transferrin saturation, which is similar to the results of two other studies performed in hospital patients in which the authors also concluded that the CHr does not perform better than standard tests for IDA. [10,12] Further studies are required in order to identify an improved marker of iron deficiency in hospital patients compared with standard biochemical and haematological tests.…”

Section: Laboratory Investigationsmentioning

confidence: 99%

“…Studies performed in elderly patients have reported a higher mean cell volume (MCV) and mean cell haemoglobin (MCH) in the IDA and ACD groups. [10,12] A study performed at Pelonomi Regional Hospital, SA, in 100 infants and children aged 6 months -6 years showed that the optimal CHr cut-off for the diagnosis of iron deficiency was 29 pg. This corresponded to a sensitivity of 86% and a specificity of 50%, using a transferrin saturation of <25% as the diagnostic criterion for iron deficiency.…”

Section: Laboratory Investigationsmentioning

confidence: 99%

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Diagnosis of iron deficiency anaemia in hospital patients: Use of the reticulocyte haemoglobin content to differentiate iron deficiency anaemia from anaemia of chronic disease

2015

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Section: Laboratory Investigationsmentioning

confidence: 99%

Section: Laboratory Investigationsmentioning

confidence: 99%

Diagnosis of iron deficiency anaemia in hospital patients: Use of the reticulocyte haemoglobin content to differentiate iron deficiency anaemia from anaemia of chronic disease

2015

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“…21 Furthermore, several studies in people showed that RET-He was able to detect ID with high sensitivity and specificity. 22,[27][28][29] Reticulocyte hemoglobin equivalent-He increased within 2 weeks after iron supplementation, leading to the conclusion that RETHe equals the diagnostic value of CHr as a sensitive and specific marker of human ID. 30 The ProCyte Dx hematology analyzer is very similar to the XT-2000iV manufactured by Sysmex Corporation (Kobe, Japan).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of reticulocyte hemoglobin content (RET‐He) in the diagnosis of iron‐deficient erythropoiesis in dogs

Fuchs

Moritz

Grußendorf³

et al. 2017

Veterinary Clinical Pathol

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Abstract:Background: Reticulocyte hemoglobin content provided by the Siemens ADVIA (CHr) is an established marker of iron deficiency. The IDEXX ProCyte Dx hematology analyzer now provides a similar variable, reticulocyte hemoglobin equivalent (RET-He). Objectives: The objective was to evaluate RET-He and its diagnostic utility in dogs, and to calculate a cutoff value for diagnosing iron-deficient erythropoiesis (IDE). Furthermore, the prevalence of RET-He values below this cutoff value was established. Methods: One hundred and seventy-one CBCs of healthy dogs were used to establish a RI. Stability of RET-He was evaluated by repeated measurements over 48 hours (n = 10). The 25-run coefficient of variation (CV) was calculated, and correlation and bias between measurements of RET-He and CHr were assessed (n = 190). A cutoff value for diagnosing IDE was calculated. The utility of RET-He in the detection of IDE was evaluated in 123 dogs. The prevalence of low RET-He values was assessed retrospectively in a multicenter study (2012)(2013)(2014) under participation of 7 veterinary clinics. Results: Reticulocyte hemoglobin equivalent with an RI of 22.2 to 28.6 pg was statistically stable over 48 hours (P = .10). The CV was 1.8%. A fair correlation (q = 0.74) between RET-He and CHr with a small bias of À0.6 pg was found. The cutoff value for diagnosing IDE was 20.9 pg (sensitivity: 85%; specificity: 99%).

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“…26 A third study showed that a Ret-He cut-off point of 26 pg had a sensitivity of 85% and specificity of 69%. 27 Taken together, these studies illustrate the relationship between low Ret-He and iron deficiency anemia.…”

Section: Discussionmentioning

confidence: 99%

Reticulocyte hemoglobin equivalent for diagnosing iron deficiency anemia in children

Rungngu

Wahani

Mantik

2016

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Background The prevalence of iron deficiency anemia (IDA) remains high in Indonesian children. When anemia is detected in a patient, the physician's task is to identify the cause, address it, provide iron therapy, and prevent recurrence. However, prevention is best done by early detection. The reticulocyte hemoglobin equivalent (Ret-He) is a direct measurement of iron level in reticulocytes recently produced in the bone marrow. The Ret-He measurement may be an early indicator of iron deficiency, as it is sensitive at the initial stage of the condition. Objective To assess for a relationship between Ret-He and IDA as well as to evaluate the usefulness of Ret-He for diagnosing IDA in children. Methods This analytic, observational study with cross-sectional approach included 50 children aged 6-12 years and was performed from November 2013 to March 2014. The subjects were divided into IDA or non-IDA groups, based on ferritin levels. A correlation analysis using logistic regression was performed and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and odds ratio (OR) were calculated. Results were considered to be statistically significant for P values <0.05. Results A low Ret-He level was significantly associated with IDA in children (P=0.005). The Ret-He cut-off point of 27.8 pg/L had sensitivity of 43.8%, specificity 85.3%, PPV 58.3%, and NPV 76.3%, with OR 4.5 (95%CI 1.1 to 17.7). Conclusion We find a significant positive relationship between Haemoglobin (Hb) and Ret-He in children, A low level of Ret-He is associated with greater risk of IDA in children. The Ret-He has a high specificity. As such, Ret-He may be useful as a screening tool for early detection of IDA in children. [Paediatr Indones. 2016;56:90-4.].

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Is analysis of the reticulocyte haemoglobin equivalent a useful test for the diagnosis of iron deficiency anaemia in geriatric patients?

Cited by 33 publications

References 31 publications

Diagnosis of iron deficiency anaemia in hospital patients: Use of the reticulocyte haemoglobin content to differentiate iron deficiency anaemia from anaemia of chronic disease

Diagnosis of iron deficiency anaemia in hospital patients: Use of the reticulocyte haemoglobin content to differentiate iron deficiency anaemia from anaemia of chronic disease

Evaluation of reticulocyte hemoglobin content (RET‐He) in the diagnosis of iron‐deficient erythropoiesis in dogs

Reticulocyte hemoglobin equivalent for diagnosing iron deficiency anemia in children

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