Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix?

Discacciati, Michelle Garcia; Simões, J. A.; Lopes, Erika S.; Silva, Samara M.; Montemor, Eliana Borin Lopes; Rabelo-Santos, Sílvia Helena; Westin, Maria Cristina A.

doi:10.1002/dc.20431

Cited by 25 publications

(27 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lack of an association observed here for BV with high grade cervical lesions differs from the positive association found in a previous study in an HIV-seropositive population in Finland [10], and in populations from Brazil, Holland, and South Africa, in which HIV-status was unrecorded [7][8][9]14]. Our results are consistent, however, with those from two European studies with HIV status unknown [13,15], and three studies in the US, two with unknown HIV-status [6,12] and one with HIV-seropositive participants [16].…”

Section: Discussioncontrasting

confidence: 99%

“…Other factors acting in conjunction with HPV infection are likely involved in promoting the oncogenic capabilities of HPV, leading to the development of cancer. Coinfection of HPV with bacterial vaginosis (BV) has been suggested to advance this process and, for more than 25 years, has been considered a possible risk factor for cervical cancer development [6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women

Denslow

Westreich

Firnhaber

et al. 2011

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Synopsis: Among HIV-seropositive women, bacterial vaginosis was not associated with an increased risk of HSIL or cervical lesion progression. Results: Among 1,954 HIV-seropositive women, the baseline prevalence of HSIL was 17%. BV prevalence was high (54%) and showed no association with prevalent HSIL (adjusted prevalence ratio: 1.12, 95% CI: 0.92, 1.35) nor with cervical lesion progression at follow-up visit (N=503) (adjusted rate ratio: 1.00, 95% CI: 0.65, 1.53). Conclusion:Among HIV-seropositive women, BV was not associated with an increased risk of HSIL or cervical lesion progression.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women

Denslow

Westreich

Firnhaber

et al. 2011

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…15,17,25,31,32 However, 2 studies showed similar frequencies of dysbacteriosis among women who had squamous intraepithelial lesions (SIL) compared with women who did not have SIL. 33,34 This discrepancy may be explained by the finding that the data in these studies were gathered simultaneously instead of over time. In addition, the presence of bacterial vaginosis was studied in women who already had cytologic abnormalities.…”

Section: Discussionmentioning

confidence: 96%

Candida and dysbacteriosis: A cytologic, population-based study of 100,605 asymptomatic women concerning cervical carcinogenesis

Engberts

Verbruggen

Boon

et al. 2007

Cancer

View full text Add to dashboard Cite

Objective Decreased clearance of apoptotic cells is suggested to be a major pathogenic factor in systemic lupus erythematosus (SLE). The aim of this study was to investigate whether the binding of SLE autoantibodies to apoptotic cells influences the phagocytosis of these cells by macrophages. Methods Apoptosis was induced in a human T cell line (Jurkat) and a keratinocyte cell line (HaCaT) by ultraviolet B irradiation. Binding of purified IgG from 26 SLE patients and 15 healthy controls to apoptotic cells was assessed by flow cytometry and Western blotting. Phagocytosis of IgG‐opsonized apoptotic cells by monocyte‐derived macrophages was assessed by light microscopy. Similar experiments were performed with a monoclonal antibody against SSA/Ro and IgG fractions from 5 patients with Sjögren's syndrome (SS) and 5 patients with rheumatoid arthritis (RA). Results IgG fractions from all 26 SLE patients bound to late apoptotic, but not early apoptotic, cells. IgG fractions isolated from SLE patients with different autoantibody profiles showed comparable levels of binding. IgG fractions from healthy controls did not bind. Opsonization of apoptotic cells with IgG fractions from SLE patients resulted in a significant inhibition of phagocytosis as compared with healthy control IgG fractions. A monoclonal antibody directed against SSA/Ro and IgG isolated from 5 antinuclear antibody (ANA)–positive patients with SS were also able to elicit these effects, whereas IgG from 5 ANA‐negative patients with RA did not. The inhibitory effect of patient IgG was abolished by blocking either the Fcγ receptors (FcγR) or the constant region of IgG, using a specific Fc‐blocking peptide. Conclusion Autoantibodies from SLE patients are able to opsonize apoptotic cells and inhibit their uptake by macrophages via an FcγR‐dependent mechanism.

show abstract

“…A study by Discacciati MG and at el, BV is associated with increased odds for prevalence and incidence of HPV as well as delayed clearance. 17 In this way BV, PID, STD, IUCD use, PTL, PRE_ PROM, elective termination of pregnancy, endometriosis, low birth weight, neonatal jaundice are associated with bacterial vaginosis.…”

Section: Outmentioning

confidence: 99%

Bacterial Vaginosis; Frequency in Opd Patients at Ghaq Hospital Sahiwal

Bano¹,

Ujala²,

Mehreen³

2017

TPMJ

View full text Add to dashboard Cite

ABSTRACT… Objectives:The aim of the study is to detect the frequency of Bacterial Vaginosis in the outpatient clinic of Obs & Gyne Department of GHAQ Sahiwal. Design: It is an observational study. Materials and methods: Setting: In the outpatient gyne department of GHAQ Sahiwal. Period: Six months. 500 patients were selected with complaint of discharge. Amsel criteria was used for diagnosis. For statistical analysis "Association test of Significance" was used. Main outcome measures: Occurrence of Bacterial Vaginosis in OPD patients and its association with certain risk factors and complications. Results: Out of 500 patients, 105 were found to have BV. So frequency is 21%. Out of 105 cases of BV, 16 (15.2%) were asymptomatic, 12 (11.42%) pregnant, 93 (88.57%) non pregnant. Significant association was found between BV, preterm labour, pre PROM and IUCD use. Conclusion: Vaginal discharge is one of the commonest reasons for hospital visit and Bacterial vaginosis is the commonest diagnosis so screening of patients with this condition is advised.

show abstract

Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix?

Cited by 25 publications

References 17 publications

Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women

Bacterial vaginosis as a risk factor for high‐grade cervical lesions and cancer in HIV‐seropositive women

Candida and dysbacteriosis: A cytologic, population-based study of 100,605 asymptomatic women concerning cervical carcinogenesis

Bacterial Vaginosis; Frequency in Opd Patients at Ghaq Hospital Sahiwal

Contact Info

Product

Resources

About