Hypertension treatment regimens used by African American adults of the Jackson Heart Study were evaluated at the first two clinical examinations (2415 persons at Exam I, 2000–2004; 2577 at Exam II, 2005–08). Blood pressure (BP) was below 140/90 mm Hg for 66% and 70% at Exam I and Exam II, respectively; JNC7 BP treatment targets were met for 56% and 61% at Exam I and Exam II, respectively. Persons with diabetes or CKD were less likely to have BP at target, as were men compared to women. Thiazide diuretics were the most commonly used anti-hypertensive medication, and persons taking a thiazide were more likely to have their BP controlled than persons not taking them; thiazides were used significantly less among men than women. Although calcium channel blockers are often considered to be effective monotherapy for African Americans, persons using calcium channel blocker monotherapy were significantly less like to be at target BP than persons using thiazide monotherapy.