“…The incidence of significant hypotension (defined as: systolic arterial pressure ≤ 70 mmHg plus twice the age in years or MAP < 43 mmHg and associated with clinical signs of altered peripheral perfusion; cold, pale, clammy, and mottled skin, associated with an increase in capillary refill time > 2 seconds); 5 and significant bradycardia (defined as: HR < 60 beats.min -1 ) or respiratory depression (oxygen saturation less than 92%) was recorded.…”