Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?

Yiğit, Ümüt; Kırzıoğlu, Fatma Yeşim; Uğuz, Abdülhadi Cihangir; Nazıroğlu, Mustafa; Özmen, Özlem

doi:10.1016/j.archoralbio.2017.04.017

Cited by 23 publications

(45 citation statements)

References 54 publications

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“…The beneficial effect of cinnamic acid derivative on experimental periodontitis was also demonstrated by Yigit et al who reported higher alveolar bone levels with cinnamic acid derivative administration. 46 Lower serum pro-inflammatory cytokine levels were also shown. 46 The present study also determined the osteoblast and osteoclast cell counts along with the RANKL and OPG expressions in the bone.…”

Section: Discussionmentioning

confidence: 94%

Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis

Karataş

Yüce

Taşkan

et al. 2020

J of Periodontal Research

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Background and Objective Periodontitis is the chronic destructive disease of the periodontium, which causes severe inflammation in the tissues. Cinnamic acid as an unsaturated carboxylic acid might prevent inflammation and periodontal destruction. The present study aimed to evaluate the effects of cinnamic acid in two different forms as free cinnamic acid and cinnamic acid liposome on experimental periodontitis in Wistar rats. Methods Thirty‐two female rats were used in the present study. Four main groups were created as follows: C: control group; P: periodontitis group; C‐P: free cinnamic acid‐administered periodontitis group; and CL‐P: cinnamic acid liposome applied group. Periodontitis was induced via ligating 4‐0 silk sutures around lower first molar teeth on both right and left mandibles. The study duration was 30 days, and the ligatures were removed from half of the rats in the periodontitis‐induced groups. The other half carried the ligatures throughout 30 days, and all rats were euthanized at 30th day. Mandibles were removed and evaluated via stereomicroscope and underwent histological procedures. Inflammatory cell counts, osteoblast, and osteoclast cell counts were determined in hematoxylin‐eosin–stained slides, and peroxisome proliferator–activated receptor (PPAR)‐γ, cyclooxygenase (COX)‐2, receptor activator of nuclear factor κ‐B (RANKL), and osteoprotegerin (OPG) expressions were evaluated by immunohistochemistry. Results Control group had the lowest bone loss, and periodontitis group which kept ligatures had the highest bone loss compared to the other groups. Ligature removal provided significant improvement in bone measurements. Cinnamic acid groups also showed lower bone loss compared to the periodontitis group. The inflammatory cell and osteoclast counts were also higher in the periodontitis group, and both applications of cinnamic acid decreased these values. Osteoblast cells were the lowest in the periodontitis group, and cinnamic acid increased these counts. PPAR‐γ and COX‐2 levels were higher in the periodontitis group, and cinnamic acid decreased these levels but not to a significant level except for the cinnamic acid liposome ligature removal group, which had significantly lower values in the PPAR‐γ and COX‐2. OPG levels were lower in the periodontitis group compared to the other groups. Cinnamic acid significantly decreased RANKL and increased OPG levels. Conclusion Periodontitis caused increased inflammation and bone destruction accompanied by increased PPAR‐γ, COX‐2, and RANKL levels and osteoclast counts. Cinnamic acid decreased osteoclast counts and inflammation and increased osteoblast counts and OPG expression in the present animal model of periodontitis.

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Section: Discussionmentioning

confidence: 94%

Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis

Karataş

Yüce

Taşkan

et al. 2020

J of Periodontal Research

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“…Recently, it has been reported that CAPE can modulate the host response [60]. Yiğit et al [19] evaluated the effects of LDD and CAPE on alveolar bone level and the plasma levels of GSH-Px activity in an experimental periodontitis rat model. They determined that GSH-Px levels in plasma increased in the CAPE + periodontitis group, but decreased in the periodontitis and periodontitis + LDD groups when compared to control group [19].…”

Section: Glutathione Peroxidase Medication and Periodontal Diseasementioning

confidence: 99%

“…Yiğit et al [19] evaluated the effects of LDD and CAPE on alveolar bone level and the plasma levels of GSH-Px activity in an experimental periodontitis rat model. They determined that GSH-Px levels in plasma increased in the CAPE + periodontitis group, but decreased in the periodontitis and periodontitis + LDD groups when compared to control group [19]. The authors stated that CAPE significantly increased GSH-Px levels and CAPE may have more antioxidant properties than LDD in periodontal inflammation [19].…”

Section: Glutathione Peroxidase Medication and Periodontal Diseasementioning

confidence: 99%

“…Several studies have shown the relationship between ROS and periodontal disease [5,[16][17][18]. Oxidative stress (OS), an imbalance between the pro-oxidant and antioxidant system, is involved in the bone resorptive process during periodontal disease [19]. Various studies have shown that OS is involved in the pathophysiological mechanisms of periodontitis [1,17,18,20,21].…”

Section: Introductionmentioning

confidence: 99%

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Periodontal Health and Disease in Glutathione Peroxidase

Dede¹

2020

Glutathione System and Oxidative Stress in Health and Disease

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Periodontal diseases are chronic, multifactorial inflammatory diseases that affect more than 10% of the world population. There are two general forms of periodontal diseases including gingivitis (reversible inflammation and confined with gingiva form) and periodontitis (irreversible, destruction form). Several studies have reported that periodontal disease was associated with a decreased antioxidant capacity and elevated oxidative damage within the oral cavity. Glutathione peroxidase (GSH-Px) is an important enzymatic antioxidant that protects periodontal tissues against oxidative stress. Hitherto, there is contradictory evidence concerning the relationship between the levels of GSH-Px and the periodontal status. Various studies have demonstrated that GSH-Px levels in different biological fluids increased, decreased, or are unaltered in individuals with periodontal disease. This discrepancy might be explained either by different determination protocols/assays applied among the studies or various dynamic processes of the periodontal disease progression. In this section, GSH-Px levels are summarized in the periodontal health and disease including the presence and absence of systemic disease, medication, wound healing, and smoking.

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“…Recently, several agents with anti‐inflammatory, anti‐infective, and antiproteinase properties have been investigated to modulate host response . Within them, anti‐inflammatory drugs have been used as a host modulator to decrease the cytokine and prostaglandin activation .…”

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confidence: 99%

Effects of colchicine on gingival inflammation, apoptosis, and alveolar bone loss in experimental periodontitis

Aral

Yay

et al. 2018

Journal of Periodontology

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Is caffeic acid phenethyl ester more protective than doxycycline in experimental periodontitis?

Cited by 23 publications

References 54 publications

Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis

Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis

Periodontal Health and Disease in Glutathione Peroxidase

Effects of colchicine on gingival inflammation, apoptosis, and alveolar bone loss in experimental periodontitis

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