Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

González, Maraelys Morales; Joa, Javier Antonio González; Cabrales, Luis Enrique Bergues; Pupo, Ana Elisa Bergues; Schneider, Baruch; Kondakci, Suleyman; Ciria, Héctor Manuel Camué; Reyes, Juan Bory; Jarque, Manuel Verdecia; Mateus, Miguel Angel O'Farril; González, Tamara Rubio; Brooks, Soraida Cándida Acosta; Cáceres, José Luis Hernández; González, Gustavo Victoriano Sierra

doi:10.1186/s12885-017-3159-y

Cited by 25 publications

(78 citation statements)

References 52 publications

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“…Additionally, other electrode array geometries can be used [Pupo et al, ]. For this, it is necessary to know the growth kinetic of this unperturbed F3II tumor in depth, as proposed in González et al []. In addition, parameter β in the MGE for DC‐perturbed tumors should be modified because the angiogenic/anti‐angiogenesis mechanism should be affected by this physical quantity, although this has not been experimentally proven.…”

Section: Discussionmentioning

confidence: 99%

“…The parameter α ( α > 0) was the intrinsic growth rate of the tumor related to the initial mitosis rate. The parameter β ( β > 0) was the growth deceleration factor related to endogenous antiangiogenesis processes by an overexpression of different antiangiogenic molecules (i.e., Angiostatin, Thrombospondin‐1 molecules) [González et al, ]. The parameter α * was the modified tumor growth rate due to DC action.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

González

Morales

Cabrales

et al. 2018

Bioelectromagnetics

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Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primary F3II tumor growing in male and female BALB/c/Cenp mice under electrochemical treatment. Different amounts of electric charge (6, 9, and 18 C) were used. Two electrodes were inserted into the base, perpendicular to the tumor's long axis, keeping about 1 cm distance between them. Results have shown that the F3II tumor is highly sensitive to direct current. The overall effectiveness (complete response + partial response) of this physical agent was ≥75.0% and observed in 59.3% (16/27) of treated F3II tumors. Complete remission of treated tumors was observed in 22.2% (6/27). An unexpected result was the death of 11 direct current-treated animals (eight females and three males). It is concluded that direct current may be addressed to significantly affect highly aggressive and metastatic primary tumor growth kinetics, including the tumor complete response. Bioelectromagnetics. 39:460-475, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

González

Morales

Cabrales

et al. 2018

Bioelectromagnetics

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“…The classical Kolmogorov-Johnson-Mehl-Avrami (KJMA) and modified Kolmogorov-Johnson-Mehl-Avrami (mKJMA) equations are used firstly to fit experimental data of untreated Sa-37 fibrosarcoma tumor that grows in BALB/c/Cenp mice and agree with the Gompertz and Logistics conventional equations [1]. Recently, it has been proposed a new equation to describe data of the unperturbed Ehrlich and Sa-37 fibrosarcoma tumors based on the conventional Gompertz (CG) equation, named Montijano-Bergues-Bory-Gompertz (MBBG) equation (we refer the reader to see equations (8) and (9) in [2]).…”

Section: Introductionmentioning

confidence: 99%

Correspondence between formulations of Avrami and Gompertz equations for untreated tumor growth kinetics

Goris¹,

Castañeda²,

Ramirez-Torres³

et al. 2020

Rev. Mex. Fís.

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The classical and modified equations of Kolmogorov-Johnson-Mehl-Avrami are compared with the equations of conventional Gompertz andMontijano-Bergues-Bory-Gompertz, in the frame of growth kinetics of tumors. For this, different analytical and numerical criteria are usedto demonstrate the similarity between them, in particular the distance of Hausdorff. The results show that these equations are similar fromthe mathematical point of view and the parameters of the Gompertz equation are explicitly related to those of the Avrami equation. It isconcluded that Modified Kolmogorov-Johnson-Mehl-Avrami and Montijano-Bergues-Bory-Gompertz equations can be used to describe thegrowth kinetics of unperturbed tumors.

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“…Some preclinical studies support the concept of early treatment for cancer because of the exponential tumor growth kinetics presenting as a clinical symptom . Computational modeling of pancreatic cancer therapy showed that early initiation of systemic therapy resulted in a better survival than a delayed therapy .…”

Section: Discussionmentioning

confidence: 99%

“…Some preclinical studies support the concept of early treatment for cancer because of the exponential tumor growth kinetics presenting as a clinical symptom. 19,20 Computational modeling of pancreatic cancer therapy showed that early initiation of systemic therapy resulted in a better survival than a delayed therapy. 21 Delay of treatment initiation may result in the development of drug-resistant micrometastases 22 and increased angiogenesis around the tumor bed in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Association of time interval between cancer diagnosis and initiation of palliative chemotherapy with overall survival in patients with unresectable pancreatic cancer

et al. 2019

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Introduction Palliative chemotherapy is the standard treatment for patients with unresectable pancreatic cancer. Whether the early initiation of palliative chemotherapy is associated with a favorable survival outcome for these patients is not known. This study aimed to analyze the association of the time interval between cancer diagnosis and initiation of palliative chemotherapy with survival outcome in patients with pancreatic cancer. Method A total of 838 patients with unresectable pancreatic cancer who underwent palliative chemotherapy from 2010 to 2016 at 4 institutions in Taiwan were retrospectively enrolled. All patients were categorized according to time interval between cancer diagnosis and initiation of palliative chemotherapy for comparison of the survival outcome. Result The median time interval was 14 days (range, 0 to 163 days) in our patient cohort. Accordingly, 22%, 29%, and 49% of the patients underwent palliative chemotherapy within 1, 1 to 2, and >2 weeks after cancer diagnosis, respectively. The survival outcome had no statistical difference among these 3 patient groups. Subgroup analyses revealed that patients with the time interval ≤2 weeks exhibited poorer survival outcome than those with the time interval >2 weeks if they initially presented with jaundice (6.1 months vs 8.4 months, P = 0.029). In contrast, patients with the time interval ≤2 weeks revealed a better survival outcome than those with the time interval >2 weeks if they initially presented with pain (8.0 vs 6.3 months, P = 0.014). Conclusion In our study, time interval between cancer diagnosis and the initiation of palliative chemotherapy >2 weeks was not associated with a poorer survival outcome for patients with unresectable pancreatic cancer. Our result might help clinicians to clarify that early initiation of palliative chemotherapy might provide survival benefit for patients who present with tumor pain, but not for those who present with jaundice.

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Is cancer a pure growth curve or does it follow a kinetics of dynamical structural transformation?

Cited by 25 publications

References 52 publications

Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

Correspondence between formulations of Avrami and Gompertz equations for untreated tumor growth kinetics

Association of time interval between cancer diagnosis and initiation of palliative chemotherapy with overall survival in patients with unresectable pancreatic cancer

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