Is cerebral spinal fluid flow associated with body mass index and head circumference in healthy children? A phase contrast magnetic resonance imaging study

Demirtaş, Gökhan; Sigirci, Ahmet; Öztürk, Mehmet; Görkem, Süreyya Burcu; Kılıç, Betül; Güngör, Serdal

doi:10.1186/s43055-020-00227-w

Cited by 3 publications

(2 citation statements)

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“…Moreover, literature is also limited in relation to the evaluation of these measurements according to biometric parameters. Demirtaş et al ( 21 ) evaluated CSF flow in 137 children and found no significant correlation between body mass index and CSF flow parameters. Although we hypothesized that mean velocity and stroke volume would correlate with BSA, we found no such correlations.…”

Section: Discussionmentioning

confidence: 99%

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects

2022

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Objective: To evaluate cerebrospinal fluid dynamics, using cine phase-contrast magnetic resonance imaging (cine-PC MRI), in healthy pediatric subjects, determining the normal flow values in this population, as well as identifying differences related to age, sex, and body surface area. Materials and Methods: This was a descriptive cross-sectional study involving 32 healthy children and adolescents, in whom the flow of cerebrospinal fluid through the cerebral aqueduct was evaluated quantitatively with cine-PC MRI. We used specialized software to analyze the images obtained with cine-PC MRI, drawing a region of interest on the aqueduct. A flow-time curve was obtained, as were automated measurements of the various parameters. Results: The following normal (mean) values were obtained: net flow, 1.10 ± 0.99 mL/m; stroke volume, 12.2 ± 10.1 μL/cycle; mean velocity, 0.72 ± 1.00 cm/s; peak systolic velocity, 5.28 ± 2.30 cm/s; peak diastolic velocity, 4.51 ± 1.77 cm/s. These values were not affected by age or sex. In addition, body surface area was not found to correlate significantly with mean velocity or stroke volume. Conclusion: In children and adolescents, the basic cerebrospinal fluid flow parameters, as determined by cine-PC MRI, appear to be independent of age and sex.

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Section: Discussionmentioning

confidence: 99%

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects

2022

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“…Also, we did not evaluate the venous outflow abnormalities and the ventricle volumes, which is a limitation of our study. In addition, PC-MRI may result in errors in quantitative measurements, due to non-linear gradients, partial volume effects, and errors in placing ROI (Demirtaş et al, 2020).…”

Section: Zamboni Et Al (mentioning

confidence: 99%

The Role of Cerebrospinal Fluid Dynamics Using Phase-Contrast Magnetic Resonance Imaging in Assessment of Multiple Sclerosis Activity

El-Galil

Shakweer

Ashour

2021

Al-Azhar Medical Journal

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Background: Multiple sclerosis (MS) is a chronic complex neurodegenerative disease, targeting the central nervous system (CNS) and widely believed to be autoimmune in nature. Alterations to the normal flow of Cerebrospinal fluid (CSF) in the brain could be a contributing factor to the accumulation of toxic substances in the brain interstitium and may be related to the pathogenesis of neurological disorders such as Alzheimer's disease and MS.Objective: To evaluate the CSF dynamics and its relation to MS activity using phase-contrast magnetic resonance imaging (PC-MRI).Patients and methods: This prospective study was performed between April 2020 and October 2020. A total of 45 cases were enrolled in this study divided into three equal groups: MS patients with active plaquesenhanced on MRI (group 1), MS patients with chronic plaques (group 2), and healthy controls (group 3). Quantitatively evaluation of the CSF flow was performed at the level of the cerebral aqueduct by PC-MRI.Results: Regarding to peak velocity, average velocity, net volume and average flow, there were no statistically significant differences between the three studied groups. Regarding to forward volume, reverse volume and aqueductal area, there were statistically significant differences between the three studied groups. Conclusion:The forward and reverse CSF flow volumes and aqueductal area were significantly higher in the MS patients. These findings may support the venous theory in MS patients, but may also be explained by atrophy-dependent ventricular dilatation independent of the venous theory in MS patients.

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CSF flow measurement in the mesencephalic aqueduct using 2D cine phase-contrast MRI in dogs with communicating internal hydrocephalus, ventriculomegaly, and physiologic ventricular spaces

Farke,

Dörn,

Schaub

et al. 2024

Front. Vet. Sci.

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BackgroundBrachycephalic dogs are overrepresented with ventricular enlargement. Cerebrospinal fluid (CSF) flow dynamics are not completely understood. MRI techniques have been used for the visualization of CSF dynamics including phase-contrast imaging.ObjectivesThis study aimed to determine a causality between CSF flow and ventriculomegaly or hydrocephalus and to compare CSF flow dynamics among dogs with ventriculomegaly, internal hydrocephalus, and physiologic ventricles.AnimalsA total of 51 client-owned dogs were included in the study.MethodsMagnetic resonance imaging (MRI)-based FLASH sequences and phase-contrast images of the brain were obtained, and the ROI was placed at the level of the mesencephalic aqueduct. ECG monitoring was performed parallel to MRI acquisition. Evaluation of flow diagrams and processing of phase-contrast images were performed using commercially available software (Argus VA80A, Siemens AG Healthcare Sector, Erlangen, Germany). Dogs were divided into three groups: Group 1 consisted of brachycephalic dogs with ventriculomegaly (group 1A) or internal hydrocephalus (group 1B), group 2 consisted of brachycephalic dogs with normal ventricles, and group 3 consisted of meso- to dolichocephalic dogs with normal ventricles.ResultsGroup 1 had a higher median Vrost (4.32 cm/s; CI: 2.94–6.33 cm/s) and Vcaud (−6.1 cm/s, CI: 3.99–9.33 cm/s) than group 2 (Vrost: 1.99 cm/s; CI 1.43–2.78 cm/s; Vcaud: 2.91 cm/s, CI: 2.01–4.21 cm/s; p = 0.008; p = 0.03) and group 3 (Vrost:1.85 cm/s, CI: 1.31–2.60 cm/s; Vcaud − 2.46 cm/s, CI 1.68–3.58 cm/s; p = 0.01; p = 0.02). The median Volcaud of group 1 (−0.23 mL/min, CI: 0.13–0.42 mL/min) was higher than that of group 2 (−0.09 mL/min, CI: 0.05 mL/min and 0.15 mL/min) (p = 0.03). Groups 1A and 1B did not differ in Vcaud, Vrost, Volcaud, and Volrost. Group 1A and 1B showed a higher median Vrost (4.01 cm/s, CI: 2.30–7.05 cm/s; 5.94 cm/s, CI: 2.16–7.88 cm/s) than group 2 (1.85 cm/s, CI: 1.24–2.80 cm/s.) (p = 0.03; p = 0.004).Conclusion and clinical importanceIncreased CSF flow velocities in rostral and caudal directions are present in dogs with ventriculomegaly and internal hydrocephalus compared to normal controls.

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Is cerebral spinal fluid flow associated with body mass index and head circumference in healthy children? A phase contrast magnetic resonance imaging study

Cited by 3 publications

References 20 publications

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects

Cine phase-contrast magnetic resonance imaging evaluation of cerebrospinal fluid flow dynamics in healthy pediatric subjects

The Role of Cerebrospinal Fluid Dynamics Using Phase-Contrast Magnetic Resonance Imaging in Assessment of Multiple Sclerosis Activity

CSF flow measurement in the mesencephalic aqueduct using 2D cine phase-contrast MRI in dogs with communicating internal hydrocephalus, ventriculomegaly, and physiologic ventricular spaces

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